Yeast Thioredoxin-Enriched Extracts for Mitigating the Allergenicity of Foods

Taketani, Yukiko; Kinugasa, Kimihiro; Furukawa, Shuhei; Nakamura, Hajime; Otsuki, Ryoko; Yasuda, Hisataka; Fujita, Takaaki; Kanzaki, Ken; Masutani, Hiroshi; Yodoi, Junji

doi:10.1271/bbb.100734

Cited by 8 publications

(4 citation statements)

References 38 publications

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“…Pretreatment or preconditioning of rat donor lungs with the cytosolic oxidoreductase abolished tissue rejection (312) and transfection of mouse donor pancreatic b-cells with a Trx1 lentivirus vector extended cell survival after transplantation (131). Interestingly, Trx also bears functions in reducing allergenicity to, for instance, milk by reduction of its major whey protein b-lactoglobulin (756,796). In addition, major protein wheat fractions (gliadins, glutenins) are enzymatically reduced (80).…”

mentioning

confidence: 99%

Thioredoxins, Glutaredoxins, and Peroxiredoxins—Molecular Mechanisms and Health Significance: from Cofactors to Antioxidants to Redox Signaling

Hanschmann

Godoy

Berndt

et al. 2013

Antioxidants & Redox Signaling

591

532

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Thioredoxins (Trxs), glutaredoxins (Grxs), and peroxiredoxins (Prxs) have been characterized as electron donors, guards of the intracellular redox state, and "antioxidants". Today, these redox catalysts are increasingly recognized for their specific role in redox signaling. The number of publications published on the functions of these proteins continues to increase exponentially. The field is experiencing an exciting transformation, from looking at a general redox homeostasis and the pathological oxidative stress model to realizing redox changes as a part of localized, rapid, specific, and reversible redox-regulated signaling events. This review summarizes the almost 50 years of research on these proteins, focusing primarily on data from vertebrates and mammals. The role of Trx fold proteins in redox signaling is discussed by looking at reaction mechanisms, reversible oxidative post-translational modifications of proteins, and characterized interaction partners. On the basis of this analysis, the specific regulatory functions are exemplified for the cellular processes of apoptosis, proliferation, and iron metabolism. The importance of Trxs, Grxs, and Prxs for human health is addressed in the second part of this review, that is, their potential impact and functions in different cell types, tissues, and various pathological conditions.

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mentioning

confidence: 99%

Thioredoxins, Glutaredoxins, and Peroxiredoxins—Molecular Mechanisms and Health Significance: from Cofactors to Antioxidants to Redox Signaling

Hanschmann

Godoy

Berndt

et al. 2013

Antioxidants & Redox Signaling

591

532

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“…Yeast TRX2, which was used in this study, is a stress-inducible cytosolic isoform in S. cerevisiae, 25,26) and its structure is similar to those of the homologs from other organisms. 27) Considering the high structural conservation and interspecies cross-reactivity of TRX, 1,28,29) yeast TRX might interact with gastric mucosal cells and affect the secretion of gastric mucus or gastric acid. However, it has not been previously reported about direct interaction of orally administered TRX and gastrointestinal cells.…”

Section: Discussionmentioning

confidence: 99%

Protective effects of oral administration of yeast thioredoxin against gastric mucosal injury

Taketani

Kinugasa

Kitajima

et al. 2014

Bioscience, Biotechnology, and Biochemistry

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Thioredoxin (TRX) is a redox regulating protein which has protective effects against oxidative stress-induced damage to cells and tissues. In this study, we investigated the effects of orally administered TRX derived from edible yeast, Saccharomyces cerevisiae, on gastric mucosa. First, we examined the digestibility of orally administered yeast TRX in mice, and detected yeast TRX in the stomach for 4 h after administration. Next, we investigated the mitigation of gastric mucosal injury after the oral administration of yeast TRX in water-immersion restraint stress and HCl/ethanol-induced gastric ulcer models. Furthermore, we conducted DNA microarray analysis, using the HCl/ethanol-induced model, which revealed that several groups of genes related to tissue repair were upregulated in ulcer regions in the stomachs of rats administered with yeast TRX. These results demonstrated the viability of the use of oral administrations of yeast TRX to protect the gastric mucosa.

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“…Consistent with these results, active systemic and passive cutaneous anaphylaxis testing on guinea pigs showed that yeast extract rich in Trx1 significantly reduced egg mucin-induced anaphylaxis. It was hypothesized that the anti-allergic activity of Trx1 itself plays a role in these effects ( 44 ). Accordingly, Trx1-rich yeast extract can potentially be used to ferment foods, such as alcoholic beverages and bread.…”

Section: Therapeutic Effects Of Trx1 On Allergic Diseasesmentioning

confidence: 99%

Thioredoxin-1: A Promising Target for the Treatment of Allergic Diseases

et al. 2022

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Thioredoxin-1 (Trx1) is an important regulator of cellular redox homeostasis that comprises a redox-active dithiol. Trx1 is induced in response to various stress conditions, such as oxidative damage, infection or inflammation, metabolic dysfunction, irradiation, and chemical exposure. It has shown excellent anti-inflammatory and immunomodulatory effects in the treatment of various human inflammatory disorders in animal models. This review focused on the protective roles and mechanisms of Trx1 in allergic diseases, such as allergic asthma, contact dermatitis, food allergies, allergic rhinitis, and drug allergies. Trx1 plays an important role in allergic diseases through processes, such as antioxidation, inhibiting macrophage migration inhibitory factor (MIF), regulating Th1/Th2 immune balance, modulating allergic inflammatory cells, and suppressing complement activation. The regulatory mechanism of Trx1 differs from that of glucocorticoids that regulates the inflammatory reactions associated with immune response suppression. Furthermore, Trx1 exerts a beneficial effect on glucocorticoid resistance of allergic inflammation by inhibiting the production and internalization of MIF. Our results suggest that Trx1 has the potential for future success in translational research.

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Yeast Thioredoxin-Enriched Extracts for Mitigating the Allergenicity of Foods

Cited by 8 publications

References 38 publications

Thioredoxins, Glutaredoxins, and Peroxiredoxins—Molecular Mechanisms and Health Significance: from Cofactors to Antioxidants to Redox Signaling

Thioredoxins, Glutaredoxins, and Peroxiredoxins—Molecular Mechanisms and Health Significance: from Cofactors to Antioxidants to Redox Signaling

Protective effects of oral administration of yeast thioredoxin against gastric mucosal injury

Thioredoxin-1: A Promising Target for the Treatment of Allergic Diseases

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