Yellow oleander poisoning in eastern province: An analysis of admission and outcome

Pirasath, Selladurai; Kanagasingam, Arulnithy

doi:10.4103/0019-5359.125879

Cited by 12 publications

(2 citation statements)

References 6 publications

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“…Pirasath and Arulnithy[ 10 ] also reported that the toxicity was not related to the number of intake of yellow oleander seeds. In their study, the patients (69%) who have taken less seeds[ 1 2 3 ] had developed more cardiotoxic manifestations than those who have taken more seeds.…”

Section: Discussionmentioning

confidence: 99%

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Acute myocardial infarction in yellow oleander poisoning

Anandhi

Raju

Basha

et al. 2018

Journal of Postgraduate Medicine

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Self-harm by consuming yellow oleander seeds has become more frequent in South Asian countries, especially Sri Lanka and in southern parts of India. Yellow oleander poisoning usually presents with gastrointestinal, cardiovascular, and neurological manifestations as well as electrolyte abnormalities. Cardiac effects can manifest as nearly any type of dysrhythmia and sudden death with very few premonitory signs. To our knowledge yellow oleander poisoning related acute myocardial infarction has not yet been reported. We report a 37-year-old man with yellow oleander poisoning who had normal sinus rhythm at presentation but within few hours developed acute ST-segment myocardial infarction.

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Section: Discussionmentioning

confidence: 99%

“…[ 5 6 7 8 9 ] They suggested that this might be due to the effect of intake of more seeds on forced and frequent vomiting by the patients. [ 10 ]…”

Section: Discussionmentioning

confidence: 99%

Acute myocardial infarction in yellow oleander poisoning

Anandhi

Raju

Basha

et al. 2018

Journal of Postgraduate Medicine

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Synthesis and Biological Evaluation of Cardiac Glycosides for Cancer Therapy by Targeting the DNA Damage Response

et al. 2022

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Cardiac glycosides (CGs) are bioactive compounds originally used to treat heart diseases, but recent studies have demonstrated their anticancer activity. We previously demonstrated that Antiaris toxicaria 2 (AT2) possesses anticancer activity in KRAS mutated lung cancers via impinging on the DNA damage response (DDR) pathway. Toward developing this class of molecules for cancer therapy, herein we report a multistep synthetic route utilizing k‐strophanthidin as the initial building block for determination of structure–activity relationships (SARs). A systematic structural design approach was applied that included modifications of the sugar moiety, the glycoside linker, stereochemistry, and lactone ring substitutions to generate a library of O‐glycosides and MeON‐neoglycosides derivatives. These molecules were screened for their anticancer activities and their impact on DDR signaling in KRAS mutant lung cancer cells. These results demonstrate the ability to chemically synthesize CG derivatives and define the SARs to optimize AT2 as a cancer therapeutic.

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Comprehensive review of cardiovascular toxicity of drugs and related agents

Mladěnka

Applová

Patočka

et al. 2018

Medicinal Research Reviews

214

120

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Cardiovascular diseases are a leading cause of morbidity and mortality in most developed countries of the world. Pharmaceuticals, illicit drugs, and toxins can significantly contribute to the overall cardiovascular burden and thus deserve attention. The present article is a systematic overview of drugs that may induce distinct cardiovascular toxicity. The compounds are classified into agents that have significant effects on the heart, blood vessels, or both. The mechanism(s) of toxic action are discussed and treatment modalities are briefly mentioned in relevant cases. Due to the large number of clinically relevant compounds discussed, this article could be of interest to a broad audience including pharmacologists and toxicologists, pharmacists, physicians, and medicinal chemists. Particular emphasis is given to clinically relevant topics including the cardiovascular toxicity of illicit sympathomimetic drugs (e.g., cocaine, amphetamines, cathinones), drugs that prolong the QT interval, antidysrhythmic drugs, digoxin and other cardioactive steroids, beta‐blockers, calcium channel blockers, female hormones, nonsteroidal anti‐inflammatory, and anticancer compounds encompassing anthracyclines and novel targeted therapy interfering with the HER2 or the vascular endothelial growth factor pathway.

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Yellow oleander poisoning in eastern province: An analysis of admission and outcome

Cited by 12 publications

References 6 publications

Acute myocardial infarction in yellow oleander poisoning

Acute myocardial infarction in yellow oleander poisoning

Synthesis and Biological Evaluation of Cardiac Glycosides for Cancer Therapy by Targeting the DNA Damage Response

Comprehensive review of cardiovascular toxicity of drugs and related agents

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