Yin Yang 1 promotes the Warburg effect and tumorigenesis via glucose transporter GLUT3

Wang, Yali; Wu, Shourong; Huang, Can; Li, Yanjun; Zhao, Hezhao; Kasim, Vivi

doi:10.1111/cas.13662

Cited by 43 publications

(34 citation statements)

References 40 publications

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“…It has been indicated that YY1 acts as an important transcription factor to affect critical gene expression. For example, YY1 promotes tumorigenesis via regulating glucose transporter GLUT3 27 . YY1 enhances G6PD transcription and directly activates the pentose phosphate pathway to accelerate cell proliferation 28 .…”

Section: Discussionmentioning

confidence: 99%

CircAGFG1 drives metastasis and stemness in colorectal cancer by modulating YY1/CTNNB1

et al. 2020

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Colorectal cancer (CRC) is a common malignancy with high occurrence and mortality worldwide. In recent years, the overall survival rate of CRC patients has been improved because of the advances in early diagnosis and therapy. However, the prognosis of CRC patients at the advanced stage is still poor due to high recurrence rate and metastasis. The function of circular RNA (circRNA) ArfGAP with FG repeats 1 (circAGFG1) has been explored in non-small-cell lung cancer and triple-negative breast cancer. Nevertheless, its role in CRC is not clear. In this study, circAGFG1 was upregulated in CRC cell lines. CircAGFG1 silencing significantly suppressed cell proliferation, migration, invasion, and stemness, while promoted cell apoptosis in CRC. Meanwhile, we found that circAGFG1 also accelerated CRC tumor growth and metastasis in vivo. Importantly, circAGFG1 activated Wnt/β-catenin pathway through regulating CTNNB1. Afterwards, YY1 was found to transcriptionally activate CTNNB1. Furthermore, circAGFG1 directly sponged miR-4262 and miR-185-5p to upregulate YY1 expression. Eventually, rescue assays demonstrated that the effect of circAGFG1 silencing on CRC cell functions was observably reversed by upregulating YY1 or CTNNB1. In brief, our findings uncovered that circAGFG1 modulated YY1/CTNNB1 axis to drive metastasis and stemness in CRC by sponging miR-4262 and miR-185-5p.

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Section: Discussionmentioning

confidence: 99%

CircAGFG1 drives metastasis and stemness in colorectal cancer by modulating YY1/CTNNB1

et al. 2020

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“…YY1 can function as transcription factor and plays an important regulatory role in various biological processes by binding to DNA and numerous proteins, consequently impacting the pathologic processes of cancers [19][20][21][22]. YY1 has been reported to induce lncRNA MCM3AP-AS1 overexpression in lung cancer, and overexpressed MCM3AP-AS1 promoted angiogenesis via targeting KPNA4 through shared miR-340-5p [23].…”

Section: Discussionmentioning

confidence: 99%

Molecular interplay between linc01134 and YY1 dictates hepatocellular carcinoma progression

Rong

Wang

et al. 2020

J Exp Clin Cancer Res

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Background: Revealing the mechanical role of long non-coding RNAs (lncRNAs) in tumorigenesis can contribute to novel therapeutic target for cancers. The regulatory role of linc01134 in hepatocellular carcinoma (HCC) has not been studied yet. Materials and methods: qRT-PCR and western blot were conducted to measure relevant RNA and protein expressions. CCK-8, colony formation, EdU, flow cytometry, wound-healing, transwell assays and xenograft experiments were performed to determine the role of linc01134 in HCC. ChIP and luciferase reporter assays were performed to analyze the effects of Yin Yang-1 (YY1) on linc01134 transcription activity. Relevant mechanical experiments were performed to verify interaction between relative genes. Results: YY1 enhanced linc01134 transcription by interacting with linc01134 promoter. Knockdown of linc01134 inhibited proliferation, migration and epithelial-mesenchymal transition (EMT), yet promoting apoptosis in HCC cells. Mechanically, linc01134 acted as miR-324-5p sponge and interacted with insulin-like growth factor 2 mRNA binding protein 1 (IGF2BP1) to increase the stability of YY1 mRNA expression. Up-regulated YY1 continuously stimulated linc01134 expression by enhancing linc01134 promoter activity, forming a positive feedback loop. Conclusion: Linc01134/miR-324-5p/IGF2BP1/YY1 feedback loop mediates HCC progression, which possibly provide prognosis and treatment target of HCC.

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“…Recent experimental studies have demonstrated its role in the silencing of oxidative phosphorylation and switching to aerobic glycolysis [ 53 ]. Additionally, an oncogenic transcription factor, Yin Yang 1 (YY1), promotes aerobic glycolysis via upregulation of GLUT3 [ 54 ].…”

Section: Molecular View Into the Warburg Effectmentioning

confidence: 99%

Flavonoids against the Warburg phenotype—concepts of predictive, preventive and personalised medicine to cut the Gordian knot of cancer cell metabolism

et al. 2020

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The Warburg effect is characterised by increased glucose uptake and lactate secretion in cancer cells resulting from metabolic transformation in tumour tissue. The corresponding molecular pathways switch from oxidative phosphorylation to aerobic glycolysis, due to changes in glucose degradation mechanisms known as the 'Warburg reprogramming' of cancer cells. Key glycolytic enzymes, glucose transporters and transcription factors involved in the Warburg transformation are frequently dysregulated during carcinogenesis considered as promising diagnostic and prognostic markers as well as treatment targets. Flavonoids are molecules with pleiotropic activities. The metabolism-regulating anticancer effects of flavonoids are broadly demonstrated in preclinical studies. Flavonoids modulate key pathways involved in the Warburg phenotype including but not limited to PKM2, HK2, GLUT1 and HIF-1. The corresponding molecular mechanisms and clinical relevance of 'anti-Warburg' effects of flavonoids are discussed in this review article. The most prominent examples are provided for the potential application of targeted 'anti-Warburg' measures in cancer management. Individualised profiling and patient stratification are presented as powerful tools for implementing targeted 'anti-Warburg' measures in the context of predictive, preventive and personalised medicine.

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Yin Yang 1 promotes the Warburg effect and tumorigenesis via glucose transporter GLUT3

Cited by 43 publications

References 40 publications

CircAGFG1 drives metastasis and stemness in colorectal cancer by modulating YY1/CTNNB1

CircAGFG1 drives metastasis and stemness in colorectal cancer by modulating YY1/CTNNB1

Molecular interplay between linc01134 and YY1 dictates hepatocellular carcinoma progression

Flavonoids against the Warburg phenotype—concepts of predictive, preventive and personalised medicine to cut the Gordian knot of cancer cell metabolism

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