Yin/Yang Modulation of Lysosomal Enzyme Release From Polymorphonuclear Leukocytes by Cyclic Nucleotides*

Weissmann, Gerald; Goldstein, Ira M.; Hoffstein, Sylvia; Chauvet, Geneviève; Robineaux, R

doi:10.1111/j.1749-6632.1975.tb36049.x

Cited by 66 publications

(18 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although cyclic AMP has been found to inhibit degranulation in mouse peritoneal macrophages which were ingesting zymosan (Weissmann et al, 1971), less encouraging observations have also been reported. Hormonally elicited increases in cyclic AMP in rat peritoneal macrophages did not impair intracellular digestion of antibody-coated erythrocytes (Gemsa et al, 1975a).…”

mentioning

confidence: 85%

“…The fusion of lysosomes with developing phagosomes or external plasma membrane in human polymorphonuclear leukocytes was shown to be modulated by endogenous or exogenous cyclic nucleotides (Weissmann et al, 1975;Ignarro, 1975). The extent of fusion was dependent on the balance between opposing effects of cyclic AMP (fusion-inhibitory) and cyclic GMP (fusion-promoting).…”

mentioning

confidence: 99%

“…If this were so, then antibody precoated on to tubercle bacilli might have promoted fusion by stimulating an unusually large synthesis of cyclic GMP, nullifying the postulated inhibitory effect of cyclic AMP. Precedent for such an effect may be available in the promotion of cyclic GMP synthesis and degranulation in polymorphonuclear leukocytes via stimulation of antibody and complement receptors on the plasma membrane (Tgnarro & George, 1974;Weissmann et al, 1975).…”

mentioning

confidence: 99%

See 2 more Smart Citations

Phagosome-Lysosome Fusion and Cyclic Adenosine 3': 5'-Monophosphate in Macrophages Infected with Mycobacterium microti, Mycobacterium bovis BCG or Mycobacterium lepraemurium

Lowrie

Aber

Jackett

1979

Journal of General Microbiology

View full text Add to dashboard Cite

When ingested by mouse peritoneal macrophage monolayers, live Mycobacterium microti caused a sustained increase in monolayer cyclic AMP content and fusion of lysosomes with the bacterium-containing phagosomes was impaired. Ingested live M . bovis BCG caused a transient increase in cyclic AMP and the defect in phagolysosome formation was less pronounced. Dead mycobacteria and live M . lepraemurium neither enhanced monolayer cyclic AMP content nor inhibited phagolysosome formation, Mycobacterium microti and BCG exceeded M . lepraemurium in cyclic AMP-synthesizing activity in vitro but the question of whether bacterial cyclic AMP contributed substantially to the increments in infected macrophages was not resolved. Anti body-coated BCG retained the ability to synthesize cyclic AMP and to enhance monolayer cyclic AMP but lost the ability to inhibit phagolysosome formation in macrophages. The observations are discussed in terms of possible control of phagolysosome formation by cyclic nucleotides.

show abstract

mentioning

confidence: 85%

mentioning

confidence: 99%

mentioning

confidence: 99%

See 1 more Smart Citation

Phagosome-Lysosome Fusion and Cyclic Adenosine 3': 5'-Monophosphate in Macrophages Infected with Mycobacterium microti, Mycobacterium bovis BCG or Mycobacterium lepraemurium

Lowrie

Aber

Jackett

1979

Journal of General Microbiology

View full text Add to dashboard Cite

show abstract

“…The principal observation of these studies-that Cstimulated granulocytes damage endothelial cells suggested initially that a significant effector of this injury might be lysosomal enzymes released as in the "frustrated phagocytosis" model (27)(28)(29). In this model, granulocytes that encounter immune complexes or aggregated immunoglobulin deposited on solid surfaces adhere to, and selectively release their lysosomal constituents thereupon, by a process of reverse endocytosis.…”

Section: Discussionmentioning

confidence: 99%

Oxygen radicals mediate endothelial cell damage by complement-stimulated granulocytes. An in vitro model of immune vascular damage.

Sacks¹,

Moldow²,

Craddock³

et al. 1978

J. Clin. Invest.

1,036

319

View full text Add to dashboard Cite

“…More than 20 yr ago, cGMP was proposed as a positive regulator of neutrophil granule secretion (Becker and Henson, 1973;Ignarro, 1975;Weissmann et al, 1975). We reported (Wyatt et al, 1993) that cGMP levels were elevated in adherent neutrophils activated with fMLP or A23187 at the time of secretion of lactoferrin (LF, specific granule marker) and myeloperoxidase (MPO, azurophil granule marker).…”

Section: Introductionmentioning

confidence: 99%

Chemotactic Peptide-induced Changes of Intermediate Filament Organization in Neutrophils during Granule Secretion: Role of Cyclic Guanosine Monophosphate

Pryzwansky

Merricks

1998

MBoC

View full text Add to dashboard Cite

In neutrophils activated to secrete with formyl-methionyl-leucyl-phenylalanine, intermediate filaments are phosphorylated transiently by cyclic guanosine monophosphate (cGMP)-dependent protein kinase (G-kinase). cGMP regulation of vimentin organization was investigated. During granule secretion, cGMP levels were elevated and intermediate filaments were transiently assembled at the pericortex to areas devoid of granules and microfilaments. Microtubule and microfilament inhibitors affected intermediate filament organization, granule secretion, and cGMP levels. Cytochalasin D and nocodazole caused intermediate filaments to assemble at the nucleus, rather than at the pericortex. cGMP levels were elevated in neutrophils by both inhibitors; however, with cytochalasin D, cGMP was elevated earlier and granule secretion was excessive. Nocodazole did not affect normal cGMP elevations, but specific granule secretion was delayed. LY83583, a guanylyl cyclase antagonist, inhibited granule secretion and intermediate filament organization, but not microtubule or microfilament organization. Intermediate filament assembly at the pericortex and secretion were partially restored by 8-bromo-cGMP in LY83583-treated neutrophils, suggesting that cGMP regulates these functions. G-kinase directly induced intermediate filament assembly in situ, and protein phosphatase 1 disassembled filaments. However, in intact cells stimulated with formyl-methionylleucyl-phenylalanine, intermediate filament assembly is focal and transient, suggesting that vimentin phosphorylation is compartmentalized. We propose that, in addition to changes in microfilament and microtubule organization, granule secretion is also accompanied by changes in intermediate filament organization, and that cGMP regulates vimentin filament organization via activation of G-kinase.

show abstract

Yin/Yang Modulation of Lysosomal Enzyme Release From Polymorphonuclear Leukocytes by Cyclic Nucleotides*

Cited by 66 publications

References 27 publications

Phagosome-Lysosome Fusion and Cyclic Adenosine 3': 5'-Monophosphate in Macrophages Infected with Mycobacterium microti, Mycobacterium bovis BCG or Mycobacterium lepraemurium

Phagosome-Lysosome Fusion and Cyclic Adenosine 3': 5'-Monophosphate in Macrophages Infected with Mycobacterium microti, Mycobacterium bovis BCG or Mycobacterium lepraemurium

Oxygen radicals mediate endothelial cell damage by complement-stimulated granulocytes. An in vitro model of immune vascular damage.

Chemotactic Peptide-induced Changes of Intermediate Filament Organization in Neutrophils during Granule Secretion: Role of Cyclic Guanosine Monophosphate

Contact Info

Product

Resources

About