YKL-40 Protein Correlates with the Phenotype of Asthma

Specjalski, Krzysztof; Chełmińska, Marta; Jassem, Ewa

doi:10.1007/s00408-015-9693-y

Cited by 30 publications

(24 citation statements)

References 30 publications

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“…Furthermore, this study recorded a significant relationship between serum YKL40 levels and acute asthma exacerbation in children (p<0.001), this go in line with a previous report by Specjalski et al , who reported that in asthmatics, the level of serum YKL40 was significantly higher in the subgroup with poor control of symptoms and exacerbations compared with stable asthmatics 14. This also, was supported by Tang et al , in their study which showed higher serum YKL40 in patients with more severe or uncontrolled asthma 15.…”

Section: Discussionsupporting

confidence: 92%

Increased expression of serum periostin and YKL40 in children with severe asthma and asthma exacerbation

Basha

Osman

Abdelaal

et al. 2018

Journal of Investigative Medicine

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Children with severe asthma or acute asthma exacerbation may encounter difficulties in performing pulmonary function tests. In this situation, serum biomarkers can play a great role in evaluation of such patients. The aim of this study was to estimate the serum levels of human chitinase-3-like protein 1 (YKL40) and periostin in a group of Egyptian children with asthma during acute asthma exacerbation and in stable asthmatics compared with healthy control, and to correlate these findings with the severity of asthma. This cross-sectional study enrolled 120 childrenwith asthma with different degrees of asthma severity, according to the Global Initiative for Asthma guidelines, along with 60 age-matched and sex-matched healthy control. A complete blood count and an estimation of serum periostin and YKL40 levels were performed for all cases and control. Individual and mean values of periostin and YKL40 were significantly higher during acute asthma exacerbations, p<0.001. A highly significant relation between serum levels of periostin and YKL40 and asthma severity, p value for each was <0.001. Absolute eosinophil count was significantly correlated with the serum periostin levels in stable asthmatic group (p=0.01) only. There was significantly positive correlation (P<0.001) between both markers in stable asthmatic group. Spearman's correlation coefficient shows a statistically significant positive correlation between both markers and patient's age and duration of asthma, p value for each was 0.001. These findings highlight the importance of periostin and YKL40 as serum biomarkers for assessment of asthma severity and acute asthma exacerbations in children with asthma.

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Section: Discussionsupporting

confidence: 92%

Increased expression of serum periostin and YKL40 in children with severe asthma and asthma exacerbation

Basha

Osman

Abdelaal

et al. 2018

Journal of Investigative Medicine

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“…In the present study, we also observed the highest levels of YKL-40 and chitotriosidase in patients with COPD, further suggesting that the chitinases are not Th2-specific markers of airway disease. Interestingly, a weak association with increased BMI was observed, which has also been described previously (32). In contrast to our findings, initial studies in mice did suggest an involvement in Th2-type processes, as the expression of chitinase proteins (AMCase, Ym1, and Ym2) is dependent on IL-13 (3, 33, 34) and mice lacking Brp39 (YKL-40) have defective IL-13-induced inflammation (35).…”

Section: Discussionsupporting

confidence: 57%

Increased YKL-40 and Chitotriosidase in Asthma and Chronic Obstructive Pulmonary Disease

James

Reinius

Verhoek

et al. 2016

Am J Respir Crit Care Med

113

102

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Rationale: Serum chitinases may be novel biomarkers of airway inflammation and remodeling, but less is known about factors regulating their levels.Objectives: To examine serum chitotriosidase activity and YKL-40 levels in patients with asthma and chronic obstructive pulmonary disease (COPD) and evaluate clinically relevant factors that may affect chitinase levels, including genetic variability, corticosteroid treatment, disease exacerbations, and allergen exposure.Methods: Serum chitotriosidase (CHIT1) activity and YKL-40 (CHI3L1) levels, as well as the CHIT1 rs3831317 and CHI3L1 rs4950928 genotypes, were examined in subsets of patients with mild to moderate asthma (n = 76), severe asthma (n = 93), and COPD (n = 64) taking part in the European multicenter BIOAIR (Longitudinal Assessment of Clinical Course and Biomarkers in Severe Chronic Airway Disease) study. Blood was obtained at baseline, before and after a 2-week oral steroid intervention, up to six times during a 1-year period, and during exacerbations. Baseline chitinase levels were also measured in 72 healthy control subjects. The effect of allergen inhalation on blood and sputum YKL-40 levels was measured in two separate groups of patients with mild atopic asthma; one group underwent repeated low-dose allergen challenge (n = 15), and the other underwent high-dose allergen challenge (n = 16).Measurements and Main Results: Serum chitotriosidase and YKL-40 were significantly elevated in patients with asthma and those with COPD compared with healthy control subjects. Genotype and age strongly affected both YKL-40 and chitotriosidase activity, but associations with disease remained following adjustment for these factors. Correlations were observed with lung function but not with other biomarkers, including exhaled nitric oxide, blood eosinophils, periostin, and IgE. Generally, acute exacerbations, allergen-induced airway obstruction, and corticosteroid treatment did not affect circulating chitinase levels.Conclusions: YKL-40 and chitotriosidase are increased in asthma and more so in COPD. The data in the present study support these substances as being relatively steroid-insensitive, non-T-helper cell type 2-type biomarkers distinctly related to chronic inflammatory disease processes.

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“…High levels of YKL-40 in serum, bronchoalveolar lavage fluid, or sputum were found in various pulmonary disorders. In asthma, YKL-40 levels correlated with some clinical signs such as exacerbation, level of control, and obesity [66,67,68,69]. In chronic obstructive pulmonary disease, high levels of YKL-40 were shown to correlate with disease severity and overall survival [70,71].…”

Section: Chitinase-like Proteinsmentioning

confidence: 99%

Perspectives for Monocyte/Macrophage-Based Diagnostics of Chronic Inflammation

Kzhyshkowska¹,

Gudima

Moganti

et al. 2016

Transfus Med Hemother

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Low-grade chronic inflammation underlies the development of the most dangerous cardiometabolic disorders including type 2 diabetes and its vascular complications. In contrast to acute inflammation induced by bacteria and viruses, chronic inflammation can be driven by abnormal reaction to endogenous factors, including Th2 cytokines, metabolic factors like advanced glycation end products (AGEs), modified lipoproteins, or hyperglycemia. The key innate immune cells that recognize these factors in blood circulation are monocytes. Inflammatory programming of monocytes which migrate into tissues can, in turn, result into generation of tissue macrophages with pathological functions. Therefore, determination of the molecular and functional phenotype of circulating monocytes is a very promising diagnostic tool for the identification of hidden inflammation, which can precede the development of the pathology. Here we propose a new test system for the identification of inflammatory programming of monocytes: surface biomarkers and ex vivo functional system. We summarize the current knowledge about surface biomarkers for monocyte subsets, including CD16, CCR2, CX3CR1, CD64, stabilin-1 and CD36, and their association with inflammatory human disorders. Furthermore, we present the design of an ex vivo monocyte-based test system with minimal set of parameters as a potential diagnostic tool for the identification of personalized inflammatory responses.

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YKL-40 Protein Correlates with the Phenotype of Asthma

Cited by 30 publications

References 30 publications

Increased expression of serum periostin and YKL40 in children with severe asthma and asthma exacerbation

Increased expression of serum periostin and YKL40 in children with severe asthma and asthma exacerbation

Increased YKL-40 and Chitotriosidase in Asthma and Chronic Obstructive Pulmonary Disease

Perspectives for Monocyte/Macrophage-Based Diagnostics of Chronic Inflammation

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