Young Adults With Head and Neck Cancer Express Increased Susceptibility to Mutagen-lnduced Chromosome Damage

Schantz, Stimson P.; Hsu, T. C.; Ainslie, Nancy; Moser, Richard P.

doi:10.1001/jama.1989.03430230098033

Cited by 78 publications

(22 citation statements)

References 14 publications

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“…This finding agrees with those of previous studies which reported increasing rates for oral cavity tumours (especially oral tongue cancer) in individuals younger than 40 years of age in India, 3 Europe, 4 the USA 5,53 and China. 6 Association studies on HNC risk factors among YA have been performed in several countries 9,10,49,50,[54][55][56][57][58][59][60][61][62][63][64][65][66][67][68] . Most of the studies only included young patients with oral [49][50][51][57][58][59][60][61]63,64 and pharyngeal cancers, 9,65 whereas some other studies included only laryngeal cancer patients 68 and some included all HNC subsites.…”

Section: Discussionmentioning

confidence: 99%

Risk factors for head and neck cancer in young adults: a pooled analysis in the INHANCE consortium

Toporcov

Znaor

Zhang

et al. 2015

International Journal of Epidemiology

142

124

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Section: Discussionmentioning

confidence: 99%

Risk factors for head and neck cancer in young adults: a pooled analysis in the INHANCE consortium

Toporcov

Znaor

Zhang

et al. 2015

International Journal of Epidemiology

142

124

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“…The high number of expected occult metastasis in tongue tumours (∼30 %) also decreases the sensitivity of the analysis [3]. The survival of young tongue cancer patients is a much debated subject, and there are as many studies showing no difference or an even better prognosis in young patients as there are studies showing a poor prognosis [24–29, 33]. In this small cohort of 38 patients, we did not see any significant difference in overall survival between young and old patients.…”

Section: Discussionmentioning

confidence: 99%

Expression of CXCL10 is associated with response to radiotherapy and overall survival in squamous cell carcinoma of the tongue

et al. 2014

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Five-year survival for patients with oral cancer has been disappointingly stable during the last decades, creating a demand for new biomarkers and treatment targets. Lately, much focus has been set on immunomodulation as a possible treatment or an adjuvant increasing sensitivity to conventional treatments. The objective of this study was to evaluate the prognostic importance of response to radiotherapy in tongue carcinoma patients as well as the expression of the CXC-chemokines in correlation to radiation response in the same group of tumours. Thirty-eight patients with tongue carcinoma that had received radiotherapy followed by surgery were included. The prognostic impact of pathological response to radiotherapy, N-status, T-stage, age and gender was evaluated using Cox’s regression models, Kaplan-Meier survival curves and chi-square test. The expression of 23 CXC-chemokine ligands and their receptors were evaluated in all patients using microarray and qPCR and correlated with response to treatment using logistic regression. Pathological response to radiotherapy was independently associated to overall survival with a 2-year survival probability of 81 % for patients showing a complete pathological response, while patients with a non-complete response only had a probability of 42 % to survive for 2 years (p = 0.016). The expression of one CXC-chemokine, CXCL10, was significantly associated with response to radiotherapy and the group of patients with the highest CXCL10 expression responded, especially poorly (p = 0.01). CXCL10 is a potential marker for response to radiotherapy and overall survival in patients with squamous cell carcinoma of the tongue.

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“…Ligen et al found that increased p53 expression without mutation in exon 5-9 was noted in squamous cell carcinoma of the oral cavity in young, non-smoking patients [32]. Schantz et al reported greater chromosome fragility in lymphocytes from young patients with head and neck cancer following belomycin treatment [33]. Other authors have reported that cyclin D1 gene polymorphism (CCND1) was associated with the early onset of head and neck cancer, and contributed to susceptibility to head and neck cancer, particularly in young non-smokers and non-drinkers in a case-control study [34].…”

Section: Discussionmentioning

confidence: 99%

Impact of Young Age on the Prognosis for Oral Cancer: A Population-Based Study in Taiwan

Chang

et al. 2013

PLoS ONE

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BackgroundOral cancer leads to a considerable use of health care resources. Wide resection of the tumor and reconstruction with a pedicle flap/ free flap is widely used. This study was conducted to investigate if young age at the time of diagnosis of oral cancer requiring this treatment confers a worse prognosis.MethodsA total of 2339 patients who underwent resections for oral cancer from 2004 to 2005 were identified from The Taiwan National Health Insurance Research Database. Survival analysis, Cox proportional regression model, propensity scores, and sensitivity test were used to evaluate the association between 5-year survival rates and age.ResultsIn the Cox proportional regression model, the older age group (>65 years) had the worst survival rate (hazard ratio [HR], 1.80; 95% confidence interval [CI], 1.45-2.22; P<0.001). When analyzed using the propensity scores, the adjusted 5-year survival rates were also poorer for oral cancer patients with older age (>65 years), compared to those with younger age (<45 years) (P<0.001). In sensitivity test, the adjusted hazard ratio remained no statistically elevated in the younger age group (<45 years).ConclusionsFor those oral cancer patients who underwent wide excision and reconstruction, young age did not confer a worse prognosis using a Cox proportional regression model, propensity scores or sensitivity test. Young oral cancer patients may be treated using general guidelines and do not require more aggressive treatment.

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Young Adults With Head and Neck Cancer Express Increased Susceptibility to Mutagen-lnduced Chromosome Damage

Cited by 78 publications

References 14 publications

Risk factors for head and neck cancer in young adults: a pooled analysis in the INHANCE consortium

Risk factors for head and neck cancer in young adults: a pooled analysis in the INHANCE consortium

Expression of CXCL10 is associated with response to radiotherapy and overall survival in squamous cell carcinoma of the tongue

Impact of Young Age on the Prognosis for Oral Cancer: A Population-Based Study in Taiwan

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