Young neurons from medial ganglionic eminence disperse in adult and embryonic brain

Abstract

In this study, we identified neuronal precursors that can disperse through adult mammalian brain tissue. Transplanted neuronal precursors from embryonic medial ganglionic eminence (MGE), but not from lateral ganglionic eminence (LGE) or neocortex, dispersed and differentiated into neurons in multiple adult brain regions. In contrast, only LGE cells were able to migrate efficiently from the adult subventricular zone to the olfactory bulb. In embryonic brain slices, MGE cells migrated extensively toward cortex. Our results demonstrate that cells in different germinal regions have unique migratory potentials, and that adult mammalian brain can support widespread dispersion of specific populations of neuronal precursors. These findings could be useful in repair of diffuse brain damage.

Spatio-temporal specification of olfactory bulb interneurons

“…Dorsalization of the LGE is at early stages, by birth the striatum appears normal and this ''recovery'' correlates with increased levels of Gsh1 expression that compensates the Gsh2 loss (Toresson and Campbell 2001 ). MGE and LGE derived cells engrafted into adult SVZ behave similar to what is reported in the homocronically transplantation assays (Wichterle et al 1999(Wichterle et al , 2001Tucker et al 2006 ). Large numbers of LGE precursors migrate to the OB where they differentiate into periglomerular and granule cells whereas MGE cells engrafted in adult SVZ, disperse in the striatum cortex and septum without reaching the OB (Wichterle et al 1999 ).…”

“…MGE and LGE derived cells engrafted into adult SVZ behave similar to what is reported in the homocronically transplantation assays (Wichterle et al 1999(Wichterle et al , 2001Tucker et al 2006 ). Large numbers of LGE precursors migrate to the OB where they differentiate into periglomerular and granule cells whereas MGE cells engrafted in adult SVZ, disperse in the striatum cortex and septum without reaching the OB (Wichterle et al 1999 ). The local cues are insufficient to reprogram the migratory fate of MGE precursors whereas LGE cells selectively migrate along the pathway to the OB.…”

Interneuron Progenitors Attenuate the Power of Acute Focal Ictal Discharges

“…Transplanted into Adult Neocortex MGE-derived progenitors transplanted into both neonatal and adult mouse cortex have been shown to migrate, survive, and differentiate into several subgroups of cortical interneurons [10,15,17,18]. Relative to progenitors of the cortex, striatum, or hypothalamus, this migration was found to be unique to MGE-derived progenitors [10].…”

“…tissue engineered to release the potent anti-epileptic adenosine [7,8]. However, only recently have advances in understanding cortical interneuron origins [9] and appreciation of their remarkable ability to migrate and survive after transplantation into neonatal or adult cortex [10] ultimately led to interneuron transplantation studies to treat seizures in rodents [11][12][13]. Although species differences with primates appear to exist, in rodents and ferrets most cortical interneurons, including the PV and the SST expressing subgroups, originate in the medial ganglionic eminence (MGE) of the subcortical telencephalon [14].…”

Potential of GABA-ergic cell therapy for schizophrenia, neuropathic pain, and Alzheimer׳s and Parkinson׳s diseases

“…Author manuscript; available in PMC 2017 May 01. adult brain than lateral ganglionic eminence (LGE, a major source of olfactory bulb interneurons) progenitors that mostly remain in clusters at injection sites (Wichterle et al, 1999(Wichterle et al, , 2001Hattiangady et al, 2008;Southwell et al, 2014). Furthermore, MGE progenitors seem to produce the complement of interneuron subtypes normally produced by them during development even when grafted into the adult cerebral cortex, hippocampus or the spinal cord (Alvarez-Dolado et al, 2006;Wichterle et al, 1999;Southwell et al, 2010Southwell et al, , 2014Braz et al, 2012;Hvou fu am., 2013).…”