Young patients with both type 1 diabetes mellitus and asthma have a unique IL-12 and IL-18 secretory pattern

Rachmiel, Marianna; Bloch, Olga; Shaul, Aviv A.; Ben-Yehudah, Gilad; Bistritzer, Zvi; Weintrob, Naomi; Ofan, R; Rapoport, Micha J.

doi:10.1111/j.1399-5448.2010.00751.x

Cited by 16 publications

(16 citation statements)

References 35 publications

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“…Rachmiel et al, for example, investigated in 2011 the IL‐12 and IL‐18 secretion pattern in these two groups, knowing that the two cytokines play an important role in the regulation of both Th1‐ and Th2‐mediated diseases . They found that patients with both T1DM and asthma had higher serum levels of IL‐12 and IL‐18 than controls . Cytokines play an important role in inflammatory processes and therefore also in inducing beta‐cell damage in patients with T1DM .…”

Section: Discussionsupporting

confidence: 90%

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Association between IgE-mediated allergies and diabetes mellitus type 1 in children and adolescents

Klamt

Vogel

Kapellen³

et al. 2015

Pediatr Diabetes

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Section: Discussionsupporting

confidence: 90%

“…IL-12 and IL-18 than controls (41). Cytokines play an important role in inflammatory processes and therefore also in inducing beta-cell damage in patients with T1DM (15).…”

Section: Discussionmentioning

confidence: 81%

Association between IgE-mediated allergies and diabetes mellitus type 1 in children and adolescents

Klamt

Vogel

Kapellen³

et al. 2015

Pediatr Diabetes

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“…Different types of innate immune cells such as T cells, eosinophils, macrophages (M φ ), and dendritic cells (DC) as well as proinflammatory cytokines and chemokines are present during insulitis [ 4 , 9 ]. The relationship between T1DM and high levels of inflammatory cytokines such as interleukin- (IL-) 1 β [ 10 – 14 ], interferon- (IFN-) γ [ 15 ], tumor necrosis factor- (TNF-) α [ 16 ], IL-12 [ 17 , 18 ], and macrophage migration inhibitory factor (Mif) [ 19 – 24 ] has been widely recognized.…”

Section: Introductionmentioning

confidence: 99%

Altered Macrophage and Dendritic Cell Response inMif−/− Mice Reveals a Role of Mif for Inflammatory-Th1 Response in Type 1 Diabetes

Juárez-Avelar

Vázquez-Mendoza

Hiriart

et al. 2016

Journal of Diabetes Research

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Macrophage migration inhibitory factor (Mif) is highly expressed in type 1 diabetes mellitus (T1DM). However, there is limited information about how Mif influences the activation of macrophages (Mφ) and dendritic cells (DC) in T1DM. To address this issue, we induced T1DM by administering multiple low doses of streptozotocin (STZ) to Mif−/− or wild-type (Wt) BALB/c mice. We found that Mif−/− mice treated with STZ (Mif−/−STZ) developed lower levels of hyperglycemia, inflammatory cytokines, and specific pancreatic islet antigen- (PIAg-) IgG and displayed reduced cellular infiltration into the pancreatic islets compared to Wt mice treated with STZ (WtSTZ). Moreover, Mφ and DC from Mif−/−STZ displayed lower expression of MHC-II, costimulatory molecules CD80, CD86, and CD40, Toll-like receptor- (TLR-) 2, and TLR-4 than WtSTZ. These changes were associated with a reduced capacity of Mφ and DC from Mif−/−STZ to induce proliferation in ovalbumin-specific T cells. All the deficiencies observed in Mif−/−STZ were recovered by exogenous administration of recombinant Mif. These findings suggest that Mif plays a role in the molecular mechanisms of Mφ and DC activation and drives T cell responses involved in the pathology of T1DM. Therefore, Mif is a potential therapeutic target to reduce the pathology of T1DM.

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“…In our setting, more advanced disease in older recipients may be linked to more inflammation in PLN than young recipients. Pro-inflammatory IL-12, IL-1β, IL-6 and IL-17 cytokines lead to the loss of Treg from T1D patients [ 49 – 52 ]. More pro-inflammatory cytokines from older vs. young recipients may similarly reduce PLN Treg.…”

Section: Discussionmentioning

confidence: 99%

Immunological Basis for Rapid Progression of Diabetes in Older NOD Mouse Recipients Post BM-HSC Transplantation

et al. 2015

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Type I diabetes (T1D), mediated by autoreactive T cell destruction of insulin-producing islet beta cells, has been treated with bone marrow-derived hematopoietic stem cell (BM-HSC) transplantation. Older non-obese diabetic (NOD) mice recipients (3m, at disease-onset stage) receiving syngeneic BM-HSC progressed more rapidly to end-stage diabetes post-transplantation than younger recipients (4-6w, at disease-initiation stage). FACS analyses showed a higher percentage and absolute number of regulatory T cells (Treg) and lower proportion of proliferating T conventional cells (Tcon) in pancreatic lymph nodes from the resistant mice among the younger recipients compared to the rapid progressors among the older recipients. Treg distribution in spleen, mesenteric lymph nodes (MLN), blood and thymus between the two groups was similar. However, the percentage of thymic Tcon and the proliferation of Tcon in MLN and blood were lower in the young resistants. These results suggest recipient age and associated disease stage as a variable to consider in BM-HSC transplantation for treating T1D.

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Young patients with both type 1 diabetes mellitus and asthma have a unique IL-12 and IL-18 secretory pattern

Abstract: Patients with both T1DM and asthma display a different pattern of IL-12 and IL-18 expression compared to patients with one disease only and controls.

Cited by 16 publications

References 35 publications

Association between IgE-mediated allergies and diabetes mellitus type 1 in children and adolescents

Association between IgE-mediated allergies and diabetes mellitus type 1 in children and adolescents

Altered Macrophage and Dendritic Cell Response inMif−/− Mice Reveals a Role of Mif for Inflammatory-Th1 Response in Type 1 Diabetes

Immunological Basis for Rapid Progression of Diabetes in Older NOD Mouse Recipients Post BM-HSC Transplantation

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