Young Plasma Induces Antidepressant-Like Effects in Aged Rats Subjected to Chronic Mild Stress by Suppressing Indoleamine 2,3-Dioxygenase Enzyme and Kynurenine Pathway in the Prefrontal Cortex

Ghaffari-Nasab, Arshad; Badalzadeh, Reza; Mohaddes, Gisou; Javani, Gonja; Ebrahimi-Kalan, Abbas; Alipour, Mohammad Reza

doi:10.1007/s11064-021-03440-9

Cited by 10 publications

(1 citation statement)

References 63 publications

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“…However, an effect of diet was also found in this brain region, with the HFD and SUP diets having higher levels than the AIN93M diet, even in controls, with levels highest in the SUP diet. The CUMS protocol is known to induce neuroinflammation [67], and according to Ghaffari-Nasab et al [68], higher levels of inflammation in the brain are associated with increased SERT expression, particularly in the PFC, reducing serotonergic function. Thus, the increased SERT levels in the PFC of mice in the CUMS group of each diet may have been due to CUMS-induced neuroinflammation.…”

Section: Serotonin Synthesis and Metabolism Pathways In The Brainmentioning

confidence: 99%

The Effects of Chronic Unpredictable Mild Stress and Semi-Pure Diets on the Brain, Gut and Adrenal Medulla in C57BL6 Mice

Herselman,

Bobrovskaya

2023

IJMS

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Chronic stress is known to perturb serotonergic regulation in the brain, leading to mood, learning and memory impairments and increasing the risk of developing mood disorders. The influence of the gut microbiota on serotonergic regulation in the brain has received increased attention recently, justifying the investigation of the role of diet on the gut and the brain in mood disorders. Here, using a 4-week chronic unpredictable mild stress (CUMS) model in mice, we aimed to investigate the effects of a high-fat high-glycaemic index (HFD) and high-fibre fruit & vegetable “superfood” (SUP) modifications of a semi-pure AIN93M diet on behaviour, serotonin synthesis and metabolism pathway regulation in the brain and the gut, as well as the gut microbiota and the peripheral adrenal medullary system. CUMS induced anxiety-like behaviour, dysregulated the tryptophan and serotonin metabolic pathways in the hippocampus, prefrontal cortex, and colon, and altered the composition of the gut microbiota. CUMS reduced the catecholamine synthetic capacity of the adrenal glands. Differential effects were found in these parameters in the HFD and SUP diet. Thus, dietary modifications may profoundly affect the multiple dynamic systems involved in mood disorders.

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Section: Serotonin Synthesis and Metabolism Pathways In The Brainmentioning

confidence: 99%