Z-DNA binding protein 1 orchestrates innate immunity and inflammatory cell death

Song, Qixiang; Fan, Yuhang; Zhang, Huali; Wang, Nian

doi:10.1016/j.cytogfr.2024.03.005

Cited by 8 publications

(2 citation statements)

References 150 publications

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“…These UNas are also believed to play crucial roles in innate immunity and host-virus interactions [19]. Proteins preferentially recognizing left-handed nucleic acids are known [20][21][22][23].…”

Section: Overview Of Unusual Nucleic Acid Structuresmentioning

confidence: 99%

Special Issue “Bioinformatics of Unusual DNA and RNA Structures”

Bartas,

Brázda,

Pečinka

2024

IJMS

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Section: Overview Of Unusual Nucleic Acid Structuresmentioning

confidence: 99%

Special Issue “Bioinformatics of Unusual DNA and RNA Structures”

Bartas,

Brázda,

Pečinka

2024

IJMS

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“…All these three DNA-binding domains are critical for sensing DNA and are indispensable for the full activation of ZBP1 [ 57 ]. ZBP1 detects a variety of DNA and RNA viruses, such as IAV, HSV-1, and Zika virus (ZIKV) [ 58 ].…”

Section: Sensing Of Viral Nucleic Acids By Nucleic Acid Sensorsmentioning

confidence: 99%

Nucleic Acid Sensor-Mediated PANoptosis in Viral Infection

Zhu,

Qi,

Zhang

et al. 2024

Viruses

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Innate immunity, the first line of host defense against viral infections, recognizes viral components through different pattern-recognition receptors. Nucleic acids derived from viruses are mainly recognized by Toll-like receptors, nucleotide-binding domain leucine-rich repeat-containing receptors, absent in melanoma 2-like receptors, and cytosolic DNA sensors (e.g., Z-DNA-binding protein 1 and cyclic GMP-AMP synthase). Different types of nucleic acid sensors can recognize specific viruses due to their unique structures. PANoptosis is a unique form of inflammatory cell death pathway that is triggered by innate immune sensors and driven by caspases and receptor-interacting serine/threonine kinases through PANoptosome complexes. Nucleic acid sensors (e.g., Z-DNA-binding protein 1 and absent in melanoma 2) not only detect viruses, but also mediate PANoptosis through providing scaffold for the assembly of PANoptosomes. This review summarizes the structures of different nucleic acid sensors, discusses their roles in viral infections by driving PANoptosis, and highlights the crosstalk between different nucleic acid sensors. It also underscores the promising prospect of manipulating nucleic acid sensors as a therapeutic approach for viral infections.

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Nanomaterials‐Induced PANoptosis: A Promising Anti‐Tumor Strategy

Hou,

Chen,

Lei

et al. 2024

Angewandte Chemie

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Malignant tumors pose a significant threat to global public health. Promoting programmed cell death in cancer cells has become a critical strategy for cancer treatment. PANoptosis, a newly discovered form of regulated cell death, integrates key molecular components of pyroptosis, apoptosis, and necroptosis, activating these three death pathways simultaneously to achieve synergistic multi‐mechanistic killing. PANoptosis significantly inhibits cancer cell growth and resistance, making tumor‐specific induction of PANoptosis a potential cancer therapeutic strategy. Currently, cancer treatment research related to PANoptosis is mainly focused on the development of small molecules and cytokines. However, these approaches still face limitations in terms of metabolic stability and tumor specificity. The development of nanotechnology offers new opportunities for cancer treatment by improving targeting efficiency, extending circulation time, and enhancing therapeutic efficacy and safety. Additionally, the unique physicochemical properties of nanomaterials can effectively optimize PANoptosis induction strategies, establishing nanomaterials as ideal candidates for inducing PANoptosis in tumor cells. This review summarizes the concept and mechanisms of PANoptosis, highlights the latest applications of nanoagents in PANoptosis‐based anti‐cancer therapy, and discusses the challenges and future directions for clinical translation. This review will inspire further exploration and development of PANoptosis‐based cancer treatments, providing new perspectives for researchers in the field

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Z-DNA binding protein 1 orchestrates innate immunity and inflammatory cell death

Cited by 8 publications

References 150 publications

Special Issue “Bioinformatics of Unusual DNA and RNA Structures”

Special Issue “Bioinformatics of Unusual DNA and RNA Structures”

Nucleic Acid Sensor-Mediated PANoptosis in Viral Infection

Nanomaterials‐Induced PANoptosis: A Promising Anti‐Tumor Strategy

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