Zanthoxylum armatum DC extracts from fruit, bark and leaf induce hypolipidemic and hypoglycemic effects in mice- in vivo and in vitro study

Alam, Fiaz; Saqib, Qazi Najam us; Ashraf, Mohammad

doi:10.1186/s12906-018-2138-4

Cited by 49 publications

(22 citation statements)

References 30 publications

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“…Although the popularity of Z. bungeanum as a condiment is relatively low outside of China, its medicinal value merits attention. This species has been used as an ancient herbal medicine in China, and its pericarp shows anti-inflammatory and anti-bacterial activities [2], relieves arthritis [3], protects against gastric mucosal damage [4], lowers blood lipid levels [5], regulates antithrombotic effects [6], and enhances immunity [7]. A recent study found that collagen extracted from Z. schinifolium exerts positive anti-tuberculosis effects [8].…”

Section: Introductionmentioning

confidence: 99%

Single-Molecule Long-Read Sequencing of Zanthoxylum bungeanum Maxim. Transcriptome: Identification of Aroma-Related Genes

Tian

Feng

Liu

et al. 2018

Forests

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Zanthoxylum bungeanum Maxim. is an economically important tree species that is resistant to drought and infertility, and has potential medicinal and edible value. However, comprehensive genomic data are not yet available for this species, limiting its potential utility for medicinal use, breeding programs, and cultivation. Transcriptome sequencing provides an effective approach to remedying this shortcoming. Herein, single-molecule long-read sequencing and next-generation sequencing approaches were used in parallel to obtain transcript isoform structure and gene functional information in Z. bungeanum. In total, 282,101 reads of inserts (ROIs) were identified, including 134,074 full-length non-chimeric reads, among which 65,711 open reading frames (ORFs), 50,135 simple sequence repeats (SSRs), and 1492 long non-coding RNAs (lncRNAs) were detected. Functional annotation revealed metabolic pathways related to aroma components and color characteristics in Z. bungeanum. Unexpectedly, 30 transcripts were annotated as genes involved in regulating the pathogenesis of breast and colorectal cancers. This work provides a comprehensive transcriptome resource for Z. bungeanum, and lays a foundation for the further investigation and utilization of Zanthoxylum resources.

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Section: Introductionmentioning

confidence: 99%

Single-Molecule Long-Read Sequencing of Zanthoxylum bungeanum Maxim. Transcriptome: Identification of Aroma-Related Genes

Tian

Feng

Liu

et al. 2018

Forests

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“…3a), both of which utilize glycolysis to obtain the initial substrate for producing dimethylallyl diphosphate (dimethylallyl-PP). Then, dimethylallyl-PP is used to generate monoterpenoids, diterpenoids, triterpenoids, and other terpenoid compounds [14], which are the main aromatic substances involved in the special numbing taste in the fruits of Z. armatum [10]. In the present study, the results showed that almost all genes involved in terpenoid backbone biosynthesis were differentially expressed genes and detected at significant levels in the fruit samples ( Fig.…”

Section: Identification and Characterization Of Genes Involved In Termentioning

confidence: 49%

“…More than 140 components related to aromatic compounds and fatty acid biosynthesis have been gradually identified in different tissues of Z. armatum [9]. Various terpenoid substances are among the main components associated with the numbing taste of Z. armatum, including linalool (29.30%), limonene (14.30%), myrcene (6.02%), cineole (1.32%) and so on [7,10]. Terpenoids are a large category of necessary secondary metabolites in plants, includingmonoterpenes, diterpenes, sesquiterpenes, triterpenoids and other terpenoid-quinone compounds [11].…”

Section: Introductionmentioning

confidence: 99%

De novo transcriptome assembly for the five major organs of Zanthoxylum armatum and the identification of genes involved in terpenoid compound and fatty acid metabolism

et al. 2020

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De novo transcriptome assembly for the five major organs of Zanthoxylum armatum and the identification of genes involved in terpenoid compound and fatty acid metabolism Abstract Background: Zanthoxylum armatum (Z. armatum) is a highly economically important tree that presents a special numbing taste. However, the underlying regulatory mechanism of the numbing taste remains poorly understood. Thus, the elucidation of the key genes associated with numbing taste biosynthesis pathways is critical for providing genetic information on Z. armatumand the breeding of high-quality germplasms of this species.Results: Here, de novo transcriptome assembly was performed for the five major organs of Z. armatum, including the roots, stems, leaf buds, mature leaves and fruits. A total of 111,318 unigenes were generated with an average length of 1014 bp. Additionally, a large number of SSRs were obtained to improve our understanding of the phylogeny and genetics of Z. armatum. The organ-specific unigenes of the five major samples were screened and annotated via GO and KEGG enrichment analysis. A total of 53 and 34 unigenes that were exclusively upregulated in fruit samples were identified as candidate unigenes for terpenoid biosynthesis or fatty acid biosynthesis, elongation and degradation pathways, respectively. Moreover, 40 days after fertilization (Fr4 stage) could be an important period for the accumulation of terpenoid compounds during the fruit development and maturation of Z. armatum. The Fr4 stage could be a key point at which the first few steps of the fatty acid biosynthesis process are promoted, and the catalysis of subsequent reactions could be significantly induced at 62 days after fertilization (Fr6 stage). Conclusions: The present study realized de novo transcriptome assembly for the five major organs of Z. armatum. To the best of our knowledge, this study provides the first comprehensive analysis revealing the genes underlying the special numbing taste of Z. armatum. The assembled transcriptome profiles expand the available genetic information on this species and will contribute to gene functional studies, which will aid in the engineering of high-quality cultivars of Z. armatum.

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“… Tejohva/Tejovati (S), Tejbal (H), Yellow wood Tree timaru (L) Shrub (W)/bark fruit and root Essential oil (mainly contains linalool and limonene), armatamide [ 90 ] One teaspoon powder of roots or stems is taken twice a day for 1 month Methanol extracts of the fruits, leaves and bark showed α-glucosidase inhibitory activity in vitro. All the extracts at 500 mg/kg for 15 days were found to decrease fasting blood glucose levels in ALX induced diabetic mice [ 91 ] Saxifragaceae Bergenia ciliata (Haw.) Sternb.…”

Section: Resultsmentioning

confidence: 99%

“…ex RoyleAtivisha (A/S), Atish (H), Indian Atish (E)Herb (C)/rootsAatisine, dihydroatisine, hetisined, heteratisine, 12-secohetisan-2-ol, N -succinoylanthranilate, atesinol 6-benzoylheterastine, N -diethyl- N -formyllaconitine, methyl aconitine, aconitine, anthorine [84]The powder of Atish roots, Ajuga parviflora leaves and Podophyllum hexandrum roots is given twice a day (half teaspoonful) early in the morning and at night after meals up to 3 monthsThe oral administered of methanol root extract (200 mg/kg/day for 28 days) increased the levels of plasma glycoproteins and also decreased the level of sialic acid and elevated levels of hexose, hexosamine and fructose in the liver and kidney of STZ induced diabetic rats [85]Rosaceae Rubus ellipticus Sm.Golden/yellow Himalayan raspberry (E), Hinsar/Hisalu (L)Shrub (W)/fruits and rootsGallic acid, catechin, chlorogenic acid ( 18 ), caffeic acid [86]One teaspoon powder of roots is taken twice a day for 1 monthThe petroleum ether, ethanol and aqueous extracts of fruits (200 mg/kg each) exhibited antidiabetic activity using GTT in ALX induced diabetes rats [87]Rubiaceae Rubia cordifolia L.Aruna (S), Manjistha (A), Manjeeth/Majith (H), Indian madder (E), Charchora (L)Climber (C)/rootsCordifoliol, cordifodiol, rubiacordone, purpurin, alizarin [88]The infusion (25 mL) of roots is taken once a day for 40 daysThe oral administration of aqueous root extract (1 g/kg/day for 8 weeks) showed an anti-hyperglycemic effect in STZ induced diabetic rats [89]Rutaceae Zanthoxylum armatum DC.Tejohva/Tejovati (S), Tejbal (H), Yellow wood Tree timaru (L)Shrub (W)/bark fruit and rootEssential oil (mainly contains linalool and limonene), armatamide [90]One teaspoon powder of roots or stems is taken twice a day for 1 monthMethanol extracts of the fruits, leaves and bark showed α-glucosidase inhibitory activity in vitro. All the extracts at 500 mg/kg for 15 days were found to decrease fasting blood glucose levels in ALX induced diabetic mice [91]Saxifragaceae Bergenia ciliata (Haw.) Sternb.Pashanabheda (S), Patharchat (H), Hairy Bergenia (E)Herb (W)/whole plantBergenin Bergenin, catechin, gallic acid, tannic acid [92]Decoction (half cup) of aerial parts is taken before breakfast(...…”

Section: Resultsmentioning

confidence: 99%

Ethnomedicinal Investigation of Medicinal Plants of Chakrata Region (Uttarakhand) Used in the Traditional Medicine for Diabetes by Jaunsari Tribe

Kumar

Aswal

Chauhan

et al. 2019

Nat. Prod. Bioprospect.

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The Himalayan region is the treasure house of natural wealth, particularly of medicinal and aromatic plants. These plants are used by the Indian traditional healers for the past many centuries to treat various ailments such as skin disorders, asthma, diabetes, snake bite, fever, pain, eye diseases, diarrhoea, indigestion, jaundice, burn, wound, liver disorder, CNS disorders and urinary tract infection. The indigenous traditional knowledge of medicinal plants and therapies of various local communities has been lost due to changes in traditional culture and the introduction of modern technologies. Therefore, it is essential to explore the traditional knowledge of the indigenous medicinal plants mainly in such areas where there is a severe threat to natural vegetation owing to human inhabitation. The present study aimed to explore the medicinal plants of Chakrata region (Jaunsar–Bawar Hills), Uttarakhand, India used in the folk medicine for the management of diabetes by Jaunsari Tribe. In a comprehensive field survey, the information about the medicinal plants have been mainly collected from the traditional healers and other elderly people belong to the tribal community. All the information about the medicinal plants of the study area was documented in a field book. Various tools have been used to collect the samples for identification purpose and the authentication of the plants was done with the help of taxonomists. The literature on these plants was also searched from online (PubMed and Scopus) as well as from some textbooks and Ayurvedic classical texts. The present survey-based work described a total of 54 plants belonging to 47 genera and 30 families used in the traditional medicine for the management of diabetes in Chakrata region. The information gathered from the local community revealed that the plants are effective in diabetes and one can use most of them without consulting a practitioner or traditional healer. The literature revealed that most of the surveyed plants are already used in the preparation of various antidiabetic formulations such as Chandraprabha vati, Nishamalaki chunra, Amritamehari churna and Nisakathakadi kashayam along with various patent drugs which are frequently prescribed by the Ayurvedic practitioners in India. The present study explored the traditional as well as scientific knowledge on the antidiabetic plants used by the tribal community. The documented information on these plants can be further used by the scientific community to develop new drugs/formulations with the help of modern techniques.

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Zanthoxylum armatum DC extracts from fruit, bark and leaf induce hypolipidemic and hypoglycemic effects in mice- in vivo and in vitro study

Cited by 49 publications

References 30 publications

Single-Molecule Long-Read Sequencing of Zanthoxylum bungeanum Maxim. Transcriptome: Identification of Aroma-Related Genes

Single-Molecule Long-Read Sequencing of Zanthoxylum bungeanum Maxim. Transcriptome: Identification of Aroma-Related Genes

De novo transcriptome assembly for the five major organs of Zanthoxylum armatum and the identification of genes involved in terpenoid compound and fatty acid metabolism

Ethnomedicinal Investigation of Medicinal Plants of Chakrata Region (Uttarakhand) Used in the Traditional Medicine for Diabetes by Jaunsari Tribe

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