ZBTB7A functioned as an oncogene in colorectal cancer

Wang, Li; Zhang, Mengxia; Zhang, Meifang; Tu, Ziwei

doi:10.1186/s12876-020-01456-z

Cited by 10 publications

(7 citation statements)

References 26 publications

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“…However, ZBTB7A was originally known as a proto-oncoprotein due to its ability to suppress the transcription of tumor suppressor gene ARF [ 28 ]. ZBTB7A was increased in tumor tissues and promoted tumorigenesis in colorectal cancer, glioma and osteosarcoma [ 9 , 11 , 29 ]. ZBTB7A was only reported to regulate the epithelial-mesenchymal transition in BC [ 30 , 31 ].…”

Section: Discussionmentioning

confidence: 99%

“…ZBTB7A was overexpressed in breast cancer tissue and promoted cell metastasis in vitro and in vivo via NF-κB induced epithelial-mesenchymal transition [ 7 , 8 ]. Similarly, ZBTB7A was reported to be overexpressed in colorectal cancer tissues and was linked to a poor prognosis [ 9 , 10 ]. In osteosarcoma, ZBTB7A has been shown to increase chemoresistance and protect osteosarcoma cells from ER stress-induced apoptosis [ 11 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

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ZBTB7A, a miR-144-3p targeted gene, accelerates bladder cancer progression via downregulating HIC1 expression

Liu

Chou

et al. 2022

Cancer Cell Int

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Background Zinc finger and BTB domain-containing 7A (ZBTB7A) is a member of the POK family of transcription factors that plays an oncogenic or tumor-suppressive role in different cancers depending on the type and genetic context of cancer. However, the function and molecular mechanism of ZBTB7A in bladder cancer (BC) remain elusive. Methods The role of ZBTB7A in bladder cancer was detected by colony formation, transwell, and tumor formation assays. The expression levels of ZBTB7A, HIC1, and miR-144-3p were analyzed by qRT-PCR and Western blot. Bioinformatics analysis and a dual-luciferase reporter assay were used to assess the effect of ZBTB7A on the promoter activity of HIC1. Results The present study revealed that knockdown of ZBTB7A suppressed BC cell growth and migration, as indicated by an approximately 50% reduction in the number of colonies and an approximately 70% reduction in the number of migrated cells. Loss of ZBTB7A inhibited tumor growth in vivo, resulting in a 75% decrease in tumor volume and an 80% decrease in tumor weight. Further mechanistic studies revealed that ZBTB7A bound to the hypermethylated in cancer 1 (HIC1) promoter and downregulated HIC1 expression, accelerating the malignant behavior of BC. Increased expression of ZBTB7A in BC tissues was negatively corrected with the expression of HIC1. Moreover, ZBTB7A was a target of miR-144-3p, which decreased ZBTB7A expression in BC. Conclusion Our data demonstrate that ZBTB7A, a targeted gene of miR-144-3p, promoted tumorigenesis of BC through downregulating HIC1 expression.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

ZBTB7A, a miR-144-3p targeted gene, accelerates bladder cancer progression via downregulating HIC1 expression

Liu

Chou

et al. 2022

Cancer Cell Int

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“…As an essential transcriptional inhibitor, ZBTB7A presents an abnormal expression in non-small cell lung cancer, breast cancer, and other cancers [ 52 , 53 ]. For instance, considering that ZBTB7A can exert an oncogenic function in colorectal cancer patients, it can be taken as an underlying biomarker and therapeutic target for colorectal cancer [ 54 ]. Moreover, its high profile is linked to a poor prognosis in GC patients.…”

Section: Discussionmentioning

confidence: 99%

Long non-coding RNA p53 upregulated regulator of p53 levels (PURPL) promotes the development of gastric cancer

et al. 2022

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Gastric cancer (GC), one of the most prevalent malignancies across the world, has an increasing incidence rate. Long non-coding RNA (lncRNA) PURPL (also referred to as LINC01021) has been demonstrated to influence malignant GC behaviors and partake in other cancers. Notwithstanding, reports pertaining to the underlying mechanism of PURPL in GC haven’t been rarely seen. Presently, in-vivo and ex-vivo experiments were implemented to examine the PURPL-miR-137-ZBTB7A-PI3K-AKT-NF-κB regulatory axis in GC. Our statistics revealed that PURPL presented a high expression in GC tissues and cell lines. PURPL overexpression remarkably exacerbated colony formation, migration, and invasion and repressed apoptosis in GC cells (AGS and MNK-45). In-vivo experiments also corroborated that cell growth was boosted by PURPL up-regulation. Mechanistic investigations verified that PURPL interacted with miR-137 and lowered its profile in GC cell lines. miR-137 overexpression or ZBTB7A knockdown upended the oncogenic function mediated by PURPL. PURPL initiated the PI3K/AKT/NF-κB pathway. PI3K and NF-κB inhibition impaired the promoting impact on GC cells elicited by PURPL overexpression and contributed to PURPL down-regulation. These findings disclosed that PURPL serves as an oncogene in the context of GC via miR-137-ZBTB7A-PI3K-AKT-NF-κB axis modulation.

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“…Wang et al [40] prove that in one or more of the datasets, the mRNA expression level of E2F6 is significantly upregulated in human colorectal cancer (CRC) patients. ZBTB7A acts as an oncogene in CRC patients and can be used as a potential prognostic biomarker and therapeutic target in CRC patients [41]. RUVBL1, as a proteincoding gene, is associated with diseases including colorectal cancer [42].…”

Section: Identification Of Driver Transcription Factors For Disease D...mentioning

confidence: 99%

Gene regulatory network inference based on causal discovery integrating with graph neural network

Feng,

Jiang,

Yin

et al. 2023

Quant. Biol.

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Gene regulatory network (GRN) inference from gene expression data is a significant approach to understanding aspects of the biological system. Compared with generalized correlation‐based methods, causality‐inspired ones seem more rational to infer regulatory relationships. We propose GRINCD, a novel GRN inference framework empowered by graph representation learning and causal asymmetric learning, considering both linear and non‐linear regulatory relationships. First, high‐quality representation of each gene is generated using graph neural network. Then, we apply the additive noise model to predict the causal regulation of each regulator‐target pair. Additionally, we design two channels and finally assemble them for robust prediction. Through comprehensive comparisons of our framework with state‐of‐the‐art methods based on different principles on numerous datasets of diverse types and scales, the experimental results show that our framework achieves superior or comparable performance under various evaluation metrics. Our work provides a new clue for constructing GRNs, and our proposed framework GRINCD also shows potential in identifying key factors affecting cancer development.

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ZBTB7A functioned as an oncogene in colorectal cancer

Cited by 10 publications

References 26 publications

ZBTB7A, a miR-144-3p targeted gene, accelerates bladder cancer progression via downregulating HIC1 expression

ZBTB7A, a miR-144-3p targeted gene, accelerates bladder cancer progression via downregulating HIC1 expression

Long non-coding RNA p53 upregulated regulator of p53 levels (PURPL) promotes the development of gastric cancer

Gene regulatory network inference based on causal discovery integrating with graph neural network

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