ZEB1 is a Subgroup-Specific Marker of Prognosis and Potential Drug Target in Medulloblastoma

Fratini, Lívia; Dalmolin, Matheus Gibeke Siqueira; Sinigaglia, Marialva; Perla, Alexandre da Silveira; Farias, Caroline Brunetto de; Brunetto, Algemir Lunardi; Brunetto, Andre Tessainer; Jaeger, Mariane da Cunha; Roesler, Rafaël

doi:10.1007/s12017-022-08716-z

Cited by 1 publication

(1 citation statement)

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“…The expression of ZEB1 was enhanced in IDH1/2-mutant gliomas, and IDH1/2-mutant gliomas exhibited significantly lower values of ZEB1 protein [ 169 ]. The role of ZEB1 as a potential prognosis biomarker and drug target in medulloblastoma has been reported [ 170 ].…”

Section: Zeb1 Effects In Cns Tumorsmentioning

confidence: 99%

The role of the ZEB1–neuroinflammation axis in CNS disorders

Poonaki

Kahlert

Meuth

et al. 2022

J Neuroinflammation

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Zinc finger E-box binding homeobox 1 (ZEB1) is a master modulator of the epithelial–mesenchymal transition (EMT), a process whereby epithelial cells undergo a series of molecular changes and express certain characteristics of mesenchymal cells. ZEB1, in association with other EMT transcription factors, promotes neuroinflammation through changes in the production of inflammatory mediators, the morphology and function of immune cells, and multiple signaling pathways that mediate the inflammatory response. The ZEB1–neuroinflammation axis plays a pivotal role in the pathogenesis of different CNS disorders, such as brain tumors, multiple sclerosis, cerebrovascular diseases, and neuropathic pain, by promoting tumor cell proliferation and invasiveness, formation of the hostile inflammatory micromilieu surrounding neuronal tissues, dysfunction of microglia and astrocytes, impairment of angiogenesis, and dysfunction of the blood–brain barrier. Future studies are needed to elucidate whether the ZEB1–neuroinflammation axis could serve as a diagnostic, prognostic, and/or therapeutic target for CNS disorders.

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Section: Zeb1 Effects In Cns Tumorsmentioning

confidence: 99%