Zebrafish and motor control over the last decade

Fetcho, Joseph R.; Higashijima, Shin‐ichi; McLean, David L.

doi:10.1016/j.brainresrev.2007.06.018

Cited by 114 publications

(70 citation statements)

References 86 publications

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“…Circuits in the spinal cord generate locomotor movements and integrate sensory inputs as well as inputs from supraspinal centers (Hultborn et al, 1998;Kiehn, 2006;Rossignol et al, 2006;Fetcho et al, 2008;Grillner and Jessell, 2009;El Manira and Kyriakatos, 2010). Unraveling the intrinsic function of the spinal network requires model systems that are accessible for the combination of molecular and genetic tools together with electrophysiology.…”

Section: Discussionmentioning

confidence: 99%

“…Unraveling the intrinsic function of the spinal network requires model systems that are accessible for the combination of molecular and genetic tools together with electrophysiology. In this regard, the zebrafish at early developmental stages has emerged as an attractive system that already enabled some of the neuronal components for swimming and escape behavior (Drapeau et al, 2002;Kimura et al, 2006;McLean et al, 2007;Fetcho et al, 2008;Liao and Fetcho, 2008;McLean et al, 2008;Satou et al, 2009;Fetcho and McLean, 2010). These studies need to be extended from larval to juvenile and adult stages to determine whether there is further refinement of the neuronal components of the locomotor circuit that is associated with a change in the swimming behavior, from larval burst swimming to the adult pattern of slow, steady swimming movements and the organization of the motor column (van Raamsdonk et important is how the neural mechanisms responsible for interactions between the swimming and escape circuits are adapted as the animal's shape and speed of locomotion changes during development.…”

Section: Discussionmentioning

confidence: 99%

“…Spinal cord in vitro preparations from different animals have been used to study locomotor circuits (Drapeau et al, 2002;Grillner, 2003;Kiehn, 2006;Fetcho et al, 2008;Grillner and Jessell, 2009;Roberts et al, 2010). In most of these preparations, the induction of a motor pattern relies mostly on the use of excitatory amino acid agonists in combination with modulatory transmitters (Schmidt et al, 1998;Clarac et al, 2004;LeBeau et al, 2005;Kiehn, 2006;McDearmid and Drapeau, 2006;Taccola and Nistri, 2006;Gabriel et al, 2008Gabriel et al, , 2009).…”

Section: Introductionmentioning

confidence: 99%

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Initiation of Locomotion in Adult Zebrafish

Kyriakatos

Mahmood²,

Ausborn³

et al. 2011

Journal of Neuroscience

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Motor behavior is generated by specific neural circuits. Those producing locomotion are located in the spinal cord, and their activation depends on descending inputs from the brain or on sensory inputs. In this study, we have used an in vitro brainstem-spinal cord preparation from adult zebrafish to localize a region where stimulation of descending inputs can induce sustained locomotor activity. We show that a brief stimulation of descending inputs at the junction between the brainstem and spinal cord induces long-lasting swimming activity. The swimming frequencies induced are remarkably similar to those observed in freely moving adult fish, arguing that the induced locomotor episode is highly physiological. The motor pattern is mediated by activation of ionotropic glutamate and glycine receptors in the spinal cord and is not the result of synaptic interactions between neurons at the site of the stimulation in the brainstem. We also compared the activity of motoneurons during locomotor activity induced by electrical stimulation of descending inputs and by exogenously applied NMDA. Prolonged NMDA application changes the shape of the synaptic drive and action potentials in motoneurons. When escape activity occurs, the swimming activity in the intact zebrafish was interrupted and some of the motoneurons involved became inhibited in vitro. Thus, the descending inputs seem to act as a switch to turn on the activity of the spinal locomotor network in the caudal spinal cord. We propose that recurrent synaptic activity within the spinal locomotor circuits can transform a brief input into a well coordinated and long-lasting swimming pattern.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Initiation of Locomotion in Adult Zebrafish

Kyriakatos

Mahmood²,

Ausborn³

et al. 2011

Journal of Neuroscience

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“…As a model species, it is more complex, evolutionarily closer to humans, and amenable to standard genetic and molecular tools. Numerous human diseases, both genetic and acquired, can be introduced and studied in zebrafish, which made it a model vertebrate of choice for drug discovery and large-scale studies of genetics, development, and regeneration (Strahle and Korzh, 2004;Korzh, 2007;Lieschke and Currie, 2007;Fetcho et al, 2008). The optical clarity of zebrafish embryos also allows investigation of cells deep within the tissue.…”

Section: Introductionmentioning

confidence: 99%

Probing events with single molecule sensitivity in zebrafish and Drosophila embryos by fluorescence correlation spectroscopy

Shi

Teo

Pan

et al. 2009

Developmental Dynamics

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Zebrafish and Drosophila are animal models widely used in developmental biology. High-resolution microscopy and live imaging techniques have allowed the investigation of biological processes down to the cellular level in these models. Here, using fluorescence correlation spectroscopy (FCS), we show that even processes on a molecular level can be studied in these embryos. The two animal models provide different advantages and challenges. We first characterize their autofluorescence pattern and determine usable penetration depth for FCS especially in the case of zebrafish, where tissue thickness is an issue. Next, the applicability of FCS to study molecular processes is shown by the determination of blood flow velocities with high spatial resolution and the determination of diffusion coefficients of cytosolic and membrane-bound enhanced green fluorescent protein-labeled proteins in different cell types. This work provides an approach to study molecular processes in vivo and opens up the possibility to relate these molecular processes to developmental biology questions. Developmental Dynamics 238:3156-3167,

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“…Aided by advances in visualization techniques, zebrafish larvae have provided major insight into the neuroanatomy, development and physiology of the lateral line (Alexandre and Ghysen, 1999;Bricaud et al, 2001;Fame et al, 2006;Faucherre et al, 2009;Gompel et al, 2001a;Gompel et al, 2001b). Furthermore, its locomotor behavior is well characterized (Budick and O'Malley, 2000;Fuiman and Webb, 1988;Muller and van Leeuwen, 2004), and the motor control (Fetcho et al, 2008;Masino and Fetcho, 2005;McLean et al, 2007) and hydrodynamics (McHenry and Lauder, 2005;McHenry and Lauder, 2006;Muller et al, 2000;Muller et al, 2008) of this swimming are active areas of investigation. Therefore, the zebrafish offers excellent potential for integrating our understanding of the neurobiological and biomechanical principles that govern behavior.…”

Section: Introductionmentioning

confidence: 99%

Are fish less responsive to a flow stimulus when swimming?

Feitl

Ngo

McHenry

2010

Journal of Experimental Biology

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SUMMARYFish use the lateral line system to sense the water flow created by a predator's strike. Despite its potential importance to the survival of a diversity of species, it is unclear whether this ability becomes compromised when a fish swims. Therefore, the present study compared the behavioral responsiveness of swimming and motionless zebrafish (Danio rerio) larvae when exposed to the flow of a suction-feeding predator. This flow was generated with an impulse chamber, which is a device that we developed to generate a repeatable stimulus with a computer-controlled servo motor. Using high-speed video recordings, we found that about three-quarters (0.76, N121) of motionless larvae responded to the stimulus with an escape response. These larvae were 66% more likely to respond to flow directed perpendicular than flow running parallel to the body. Swimming larvae exhibited a 0.40 response probability and were therefore nearly half as likely to respond to flow as motionless larvae. However, the latency between stimulus and response was unaffected by swimming or the direction of flow. Therefore, swimming creates changes in the hydrodynamics or neurophysiology of a larval fish that diminish the probability, but not the speed, of their response to a flow stimulus. These findings demonstrate a sensory benefit to the intermittent swimming behavior observed among a broad diversity of fishes.

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Zebrafish and motor control over the last decade

Cited by 114 publications

References 86 publications

Initiation of Locomotion in Adult Zebrafish

Initiation of Locomotion in Adult Zebrafish

Probing events with single molecule sensitivity in zebrafish and Drosophila embryos by fluorescence correlation spectroscopy

Are fish less responsive to a flow stimulus when swimming?

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