Zebrafish as a model for inflammation and drug discovery

Zanandrea, Rodrigo; Bonan, Carla Denise

doi:10.1016/j.drudis.2020.09.036

Cited by 59 publications

(25 citation statements)

References 140 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In general, the embryonic, larval, and adult phases of zebrafish have been used in drug discovery. Interesting aspects related to the zebrafish model are its high fecundity, fast growth, relatively low maintenance cost, small size (either as embryos or adults), fluorescent receptor production, and optical clarity (allowing the visualization of internal organs and structures) [ 75 , 76 , 77 ]. Zebrafish have been applied in the context of studying specific diseases such as cancer [ 78 , 79 , 80 ], cardiovascular diseases [ 81 ], inflammatory diseases [ 75 , 76 ], and neurological disorders and mental health [ 82 ].…”

Section: Animal Model Context and Further Considerations For Bioactive Marine Alkaloidsmentioning

confidence: 99%

Marine Alkaloids: Compounds with In Vivo Activity and Chemical Synthesis

Munekata¹,

Pateiro²,

Conté-Júnior

et al. 2021

Marine Drugs

View full text Add to dashboard Cite

Marine alkaloids comprise a class of compounds with several nitrogenated structures that can be explored as potential natural bioactive compounds. The scientific interest in these compounds has been increasing in the last decades, and many studies have been published elucidating their chemical structure and biological effects in vitro. Following this trend, the number of in vivo studies reporting the health-related properties of marine alkaloids has been increasing and providing more information about the effects in complex organisms. Experiments with animals, especially mice and zebrafish, are revealing the potential health benefits against cancer development, cardiovascular diseases, seizures, Alzheimer’s disease, mental health disorders, inflammatory diseases, osteoporosis, cystic fibrosis, oxidative stress, human parasites, and microbial infections in vivo. Although major efforts are still necessary to increase the knowledge, especially about the translation value of the information obtained from in vivo experiments to clinical trials, marine alkaloids are promising candidates for further experiments in drug development.

show abstract

Section: Animal Model Context and Further Considerations For Bioactive Marine Alkaloidsmentioning

confidence: 99%

Marine Alkaloids: Compounds with In Vivo Activity and Chemical Synthesis

Munekata¹,

Pateiro²,

Conté-Júnior

et al. 2021

Marine Drugs

View full text Add to dashboard Cite

show abstract

“…Although mouse models are excellent to check the action of a molecule in a specific pathology, other animal models such as zebra fish allow us to quickly screen a library of compounds [102].…”

Section: In Vivo Animal Modelsmentioning

confidence: 99%

“…These mentioned models are a representative example of how in vivo models could be used to study the action of an inflammasome inhibitory molecule in specific pathology. Although mouse models are excellent to check the action of a molecule in a specific pathology, other animal models such as zebra fish allow us to quickly screen a library of compounds [ 102 ].…”

Section: Techniques To Measure Inflammasome Activationmentioning

confidence: 99%

Techniques to Study Inflammasome Activation and Inhibition by Small Molecules

et al. 2021

View full text Add to dashboard Cite

Inflammasomes are immune cytosolic oligomers involved in the initiation and progression of multiple pathologies and diseases. The tight regulation of these immune sensors is necessary to control an optimal inflammatory response and recover organism homeostasis. Prolonged activation of inflammasomes result in the development of chronic inflammatory diseases, and the use of small drug-like inhibitory molecules are emerging as promising anti-inflammatory therapies. Different aspects have to be taken in consideration when designing inflammasome inhibitors. This review summarizes the different techniques that can be used to study the mechanism of action of potential inflammasome inhibitory molecules.

show abstract

“…In this sense, the zebrafish has emerged as a key tool to study inflammatory diseases. Zebrafish present receptors, mediators, and inflammatory cells similar to mammals and humans making them suitable animal models to study new anti-inflammatory agents and their mechanisms [ 9 ]. There are different types of anti-inflammatory agents, including small molecules, peptides, and antibodies.…”

Section: Introductionmentioning

confidence: 99%

“…The extract contains only 24% salicin, which suggests other components of the extract such as flavonoids are helping to increase its effectiveness [20]. anti-inflammatory agents and their mechanisms [9]. There are different types of anti-inflammatory agents, including small molecules, peptides, and antibodies.…”

Section: Introductionmentioning

confidence: 99%

The Role of Organic Small Molecules in Pain Management

Cuesta

Meneses

2021

Molecules

View full text Add to dashboard Cite

In this review, a timeline starting at the willow bark and ending in the latest discoveries of analgesic and anti-inflammatory drugs will be discussed. Furthermore, the chemical features of the different small organic molecules that have been used in pain management will be studied. Then, the mechanism of different types of pain will be assessed, including neuropathic pain, inflammatory pain, and the relationship found between oxidative stress and pain. This will include obtaining insights into the cyclooxygenase action mechanism of nonsteroidal anti-inflammatory drugs (NSAID) such as ibuprofen and etoricoxib and the structural difference between the two cyclooxygenase isoforms leading to a selective inhibition, the action mechanism of pregabalin and its use in chronic neuropathic pain, new theories and studies on the analgesic action mechanism of paracetamol and how changes in its structure can lead to better characteristics of this drug, and cannabinoid action mechanism in managing pain through a cannabinoid receptor mechanism. Finally, an overview of the different approaches science is taking to develop more efficient molecules for pain treatment will be presented.

show abstract

Zebrafish as a model for inflammation and drug discovery

Cited by 59 publications

References 140 publications

Marine Alkaloids: Compounds with In Vivo Activity and Chemical Synthesis

Marine Alkaloids: Compounds with In Vivo Activity and Chemical Synthesis

Techniques to Study Inflammasome Activation and Inhibition by Small Molecules

The Role of Organic Small Molecules in Pain Management

Contact Info

Product

Resources

About