2017
DOI: 10.3389/fphar.2017.00515
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Zebrafish as a Model for Epilepsy-Induced Cognitive Dysfunction: A Pharmacological, Biochemical and Behavioral Approach

Abstract: Epilepsy is a neuronal disorder allied with distinct neurological and behavioral alterations characterized by recurrent spontaneous epileptic seizures. Impairment of the cognitive performances such as learning and memory is frequently observed in epileptic patients. Anti-epileptic drugs (AEDs) are efficient to the majority of patients. However, 30% of this population seems to be refractory to the drug treatment. These patients are not seizure-free and frequently they show impaired cognitive functions. Unfortun… Show more

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Cited by 97 publications
(91 citation statements)
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“…Similarly, PTZ-kindled rats displayed significant decrease in hippocampal levels of ACh ( Figure 5B), a neurotransmitter of vital role in controlling memory, attention, and learning [99]. Our results were in line with previous studies in which PTZ decreased the concentration of hippocampal ACh in rats [77,[100][101][102] and zebrafish [103,104]. However, chronic pretreatment with H3R antagonist E177 (5 and 10 mg/kg) significantly restored the depleted hippocampal ACh concentration, indicating the modulating effect of H3R antagonists E177 on cholinergic transmission function ( Figure 5B).…”
Section: Discussionsupporting
confidence: 92%
“…Similarly, PTZ-kindled rats displayed significant decrease in hippocampal levels of ACh ( Figure 5B), a neurotransmitter of vital role in controlling memory, attention, and learning [99]. Our results were in line with previous studies in which PTZ decreased the concentration of hippocampal ACh in rats [77,[100][101][102] and zebrafish [103,104]. However, chronic pretreatment with H3R antagonist E177 (5 and 10 mg/kg) significantly restored the depleted hippocampal ACh concentration, indicating the modulating effect of H3R antagonists E177 on cholinergic transmission function ( Figure 5B).…”
Section: Discussionsupporting
confidence: 92%
“…Cognitive decline induced by epilepsy is supported by number of previous studies ( Kundap et al, 2017 ). Earlier studies documented selective deficits in memory encoding in TLE ( Schwarze et al, 2009 ).…”
Section: Role Of Hmgb1 In Cognitive Dysfunctionmentioning
confidence: 62%
“…Secondly, the fish were divided into eight groups (n=8-10 per group) consisting of early life exposure to DEX (2 and 20 mg/l) and treatment with either PB 10 mg/Kg, PB 30 mg/Kg, melatonin 10 mg/kg or vehicle (DMSO), to determine the effect of PB on behavior, melatonin receptor and synthesis as well as stress related gene expression in adult zebrafish. Intraperitoneal injections were used for the PB, melatonin and vehicle (DMSO) treatment, using a standard method according to Kundap et al (42). The melatonin dose was chosen based on the work of Cuesta et al (43) whom determined that this dose produced the highest positive effects when injected into seabream (teleost fish).…”
Section: Grouping and Treatmentmentioning
confidence: 99%