Zebrafish fed on recombinant Artemia expressing epinecidin-1 exhibit increased survival and altered expression of immunomodulatory genes upon Vibrio vulnificus infection

Jheng, Yu-Hsuan; Lee, Lin-Han; Ting, Chen-Hung; Pan, Chieh-Yu; Hui, Cho-Fat; Chen, Jyh-Yih

doi:10.1016/j.fsi.2014.10.019

Cited by 28 publications

(15 citation statements)

References 36 publications

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“…; Gao, He et al . ; Ran, Carrias, Williams, Capps, Dan, Newton, Kloepper, Ooi, Browdy, Terhune & Liles ; Masso‐Silva & Diamond ), salmon (Belhaj, Desor, Gleizes, Denis, Arab‐Tehrany, Soulimani & Linder ; Neetoo & Mahomoodally ) and zebrafish (Lin, Liu, Hu & Zhang ; Zhao, Dai & Jin ; Jheng, Lee, Ting, Pan, Hui & Chen ; Wang, Meng et al . ; Wang, Chang et al .…”

Section: Biological Factorsmentioning

confidence: 99%

Application of immunostimulants in aquaculture: current knowledge and future perspectives

et al. 2016

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Similar to other industries, aquaculture constantly requires new techniques to increase production yields. Modern technologies and different scientific fields, such as biotechnology and microbiology, provide important tools that could lead to a higher quality and a greater quantity of products. New feeding practices in farming typically play an important role in aquaculture, and the addition of various additives to a balanced feed formula to achieve better growth is a common practice of many fish and shrimp feed manufacturers and farmers. As 'biofriendly agents', immunostimulants, such as biological factors, probiotics and vitamins, can be introduced into the culture environment to control and kill pathogenic bacteria, as well as to promote growth of the cultured organisms. In addition, immunostimulants are non-pathogenic and nontoxic and do not produce undesirable side effects when administered to aquatic organisms. In this review, we summarize previous studies performed with both traditional immunostimulants and the most promising new generation of immunostimulants, such as polysaccharides, nutrients, oligosaccharides, herbs, microorganisms, prebiotics and different biological factors. This review primarily focuses on their protective efficacies and on what is known concerning their effects on the immune systems of aquatic organisms when delivered in vivo.

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Section: Biological Factorsmentioning

confidence: 99%

Application of immunostimulants in aquaculture: current knowledge and future perspectives

et al. 2016

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“…In an alternative approach, zebrafish fed on transgenic brine shrimp Artemia spp. expressing an epinecidin-1 fusion protein were more resistant to infection by V. vulnificus and exhibited a greater expression of genes encoding immunomodulatory proteins including IL-1␤ and TNF-␣ in response to the pathogen [61].…”

Section: Discussionmentioning

confidence: 99%

Host-defense peptides of the skin with therapeutic potential: From hagfish to human

Conlon

2015

Peptides

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“…Among them zebrafish is carving a unique niche as the vertebrate model for PDD, as phenotype scoring can be performed with great ease because of rapid external development and optical transparency of the embryos. PDD screens performed on zebrafish have led to the identification of a number of lead compounds of therapeutic potential, for example, identification of a novel compound having a retinal vasculature specific effect,11 or larval susceptibility to infection with vibrio vulnificus ,83 or notochord lesions 84. In addition, various behavior screens have identified antipsychotic-like compounds or compounds suppressing long QT syndrome 85,86.…”

Section: Small Animal Models For Pddmentioning

confidence: 99%

Cell and small animal models for phenotypic drug discovery

Szabó

Akusjärvi

Saxena

et al. 2017

DDDT

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The phenotype-based drug discovery (PDD) approach is re-emerging as an alternative platform for drug discovery. This review provides an overview of the various model systems and technical advances in imaging and image analyses that strengthen the PDD platform. In PDD screens, compounds of therapeutic value are identified based on the phenotypic perturbations produced irrespective of target(s) or mechanism of action. In this article, examples of phenotypic changes that can be detected and quantified with relative ease in a cell-based setup are discussed. In addition, a higher order of PDD screening setup using small animal models is also explored. As PDD screens integrate physiology and multiple signaling mechanisms during the screening process, the identified hits have higher biomedical applicability. Taken together, this review highlights the advantages gained by adopting a PDD approach in drug discovery. Such a PDD platform can complement target-based systems that are currently in practice to accelerate drug discovery.

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Zebrafish fed on recombinant Artemia expressing epinecidin-1 exhibit increased survival and altered expression of immunomodulatory genes upon Vibrio vulnificus infection

Cited by 28 publications

References 36 publications

Application of immunostimulants in aquaculture: current knowledge and future perspectives

Application of immunostimulants in aquaculture: current knowledge and future perspectives

Host-defense peptides of the skin with therapeutic potential: From hagfish to human

Cell and small animal models for phenotypic drug discovery

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