Zebrafish larvae as experimental model to expedite the search for new biomarkers and treatments for neonatal sepsis

Keij, Fleur M; Koch, Bjørn E. V.; Vigario, Fernando Lozano; Simons, Sinno H P; Hasselt, Johan G. C. van; Taal, H. Rob; Knibbe, Catherijne A. J.; Spaink, Herman P.; Reiss, Irwin K M; Krekels, Elke H. J.

doi:10.1017/cts.2021.803

Cited by 4 publications

(2 citation statements)

References 126 publications

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“…The neonatal immune response could relatively easily be studied in in vitro or high-throughput animal models of sepsis. 144 Up until now animal models of sepsis rarely yielded new biomarkers or therapeutic agents that have been successfully used in clinical practice. 145 A promising new candidate model is zebrafish larvae.…”

Section: Hyperinflammationmentioning

confidence: 99%

“…Zebrafish already have been successfully exposed to pathogens relevant for neonatal sepsis, which has already resulted in the identification of factors necessary for the establishment and spread of the infection. 144 Furthermore, the emergence of -omics approaches enables researchers to map and understand physiological changes during sepsis. Rapid onsite omics approaches could be used to monitor the inflammatory response during the course of sepsis, which would enable individualized management according to the patient's functional immune status.…”

Section: Hyperinflammationmentioning

confidence: 99%

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Knowledge gaps in late-onset neonatal sepsis in preterm neonates: a roadmap for future research

et al. 2021

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Late-onset neonatal sepsis (LONS) remains an important threat to the health of preterm neonates in the neonatal intensive care unit. Strategies to optimize care for preterm neonates with LONS are likely to improve survival and long-term neurocognitive outcomes. However, many important questions on how to improve the prevention, early detection, and therapy for LONS in preterm neonates remain unanswered. This review identifies important knowledge gaps in the management of LONS and describe possible methods and technologies that can be used to resolve these knowledge gaps. The availability of computational medicine and hypothesis-free-omics approaches give way to building bedside feedback tools to guide clinicians in personalized management of LONS. Despite advances in technology, implementation in clinical practice is largely lacking although such tools would help clinicians to optimize many aspects of the management of LONS. We outline which steps are needed to get possible research findings implemented on the neonatal intensive care unit and provide a roadmap for future research initiatives.

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Section: Hyperinflammationmentioning

confidence: 99%

Section: Hyperinflammationmentioning

confidence: 99%