Zebrafish screens for new colitis treatments – a bottom‐up approach

Lee, Jou A.; Renshaw, Stephen A.

doi:10.1111/febs.14005

Cited by 4 publications

(1 citation statement)

References 18 publications

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“…While obesity-driven intestinal permeability is clinically appreciated, the molecular mechanisms are not fully known. Recent research found high-fat diet (HFD)-induced gut dysbiosis in mice to be associated with impaired intestinal barrier function maintained by the mucin layer and anti-microbial peptides [ 53 ]. Of the tight-junctional proteins, organ and tissue-specific claudin proteins and subsequent signaling pathways were modulated by HFD-induced obesity in mice, with obesity-associated secretomes contributing to these changes [ 54 ].…”

Section: Nafld Pathophysiologymentioning

confidence: 99%

The Role of the Gut Microbiome in Nonalcoholic Fatty Liver Disease

2018

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Nonalcoholic fatty liver disease (NAFLD) is the leading cause of chronic liver disease, with prevalence increasing in parallel with the rising incidence in obesity. Believed to be a “multiple-hit” disease, several factors contribute to NAFLD initiation and progression. Of these, the gut microbiome is gaining interest as a significant factor in NAFLD prevalence. In this paper, we provide an in-depth review of the progression of NAFLD, discussing the mechanistic modes of hepatocyte injury and the potential role for manipulation of the gut microbiome as a therapeutic strategy in the prevention and treatment of NAFLD.

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Section: Nafld Pathophysiologymentioning

confidence: 99%

The Role of the Gut Microbiome in Nonalcoholic Fatty Liver Disease

2018

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Comparison of the safety and efficacy of fingolimod and tofacitinib in the zebrafish model of colitis

Mousavi

Hassani²,

Baeeri³

et al. 2022

Food and Chemical Toxicology

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A Manganese-Superoxide Dismutase From Thermus thermophilus HB27 Suppresses Inflammatory Responses and Alleviates Experimentally Induced Colitis

Yang

Liu

et al. 2019

Inflammatory Bowel Diseases

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Background Superoxide dismutase (SOD) is an attractive therapeutic agent to ameliorate oxidative stress that is critical for the initiation and progression of inflammatory bowel disease (IBD). However, the short life of SOD limits its clinical application. In this study, we aim to examine the therapeutic effects of a hyperthermostable SOD from the Thermus thermophilus HB27 (TtSOD) for treatment of experimentally induced IBD. Methods A recombinant TtSOD was expressed and purified from Escherichia coli, and its therapeutic effects were examined in 2 experimental IBD animal models. Results In IBD induced by 2,4,6-trinitrobenzenesulfonic acid in zebrafish, TtSOD treatment decreased intestinal enlargement and attenuated neutrophil infiltration, resulting in alleviation of enterocolitis. In mice, SOD activity was substantially increased in the intestine after oral gavage of TtSOD, which ameliorated gut inflammation, preserved gut barrier function, and attenuated the severity of dextran sulfate sodium–induced colitis. Furthermore, TtSOD inhibited lipopolysaccharide-induced production of reactive oxygen species and inflammatory responses in mouse bone marrow–derived macrophages. Conclusions Our results demonstrate that TtSOD possesses therapeutic activities toward experimentally induced IBD, offering new clinical treatment options for patients with IBD.

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Zebrafish screens for new colitis treatments – a bottom‐up approach

Cited by 4 publications

References 18 publications

The Role of the Gut Microbiome in Nonalcoholic Fatty Liver Disease

The Role of the Gut Microbiome in Nonalcoholic Fatty Liver Disease

Comparison of the safety and efficacy of fingolimod and tofacitinib in the zebrafish model of colitis

A Manganese-Superoxide Dismutase From Thermus thermophilus HB27 Suppresses Inflammatory Responses and Alleviates Experimentally Induced Colitis

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