Zeolithe A—A phosphate substitute for detergents: Toxicological investigation

Comparison of Synthetic Zeolite Catalysts and Alumina Binders Administered Intratracheally to Rats

“…More severe pulmonary reactions to this high dose of material were absent for most of the samples, although NiW/ZSM-5/Al 2 O 3 produced some unexpected acute toxicity. Generally, these results are consistent with the anticipated effects of insoluble particles with low toxicity and also with the lack of significant toxicity from synthetic zeolites reported by Tatrai et al (1991), Kruglikov et al (1990), and Gloxhuber et al (1983).…”

“…These results support the idea of a lack of long-term effects from exposure to normal concentrations of these materials in the workplace; therefore no follow-up inhalation studies were conducted. The limited effects of ZSM-5 zeolite were consistent with previously published work on similar synthetic zeolites (Gloxhuber et al, 1983;Thomas & Ballantyne, 1992). The effects observed with the aluminas also agreed with previous studies (Ess et al, 1993;King et al, 1955;Stacy et al, 1959), some of which were used to set the current threshold limit value at 10 mg/m 3 for a -alumina.…”

“…Gloxhuber et al (1983) reported on a series of toxicity studies with Zeolite A, a sodium aluminum silicate used in detergents. Rats were exposed for 22 mo and hamsters for 12 mo to 19 mg/m 3 .…”

Pure, single phase, high crystalline, chamfered-edge zeolite 4A synthesized from coal fly ash for use as a builder in detergents

“…Synthetic zeolite 4A from pure chemicals has undergone intensive toxicological studies and has been shown to be nontoxic to living organisms [48,49]. In particular, no allergenic or irritancy potential was identified upon skin contact or inhalation.…”

Activated and Micronized Zeolite in the Modulation of Cellular Oxidative Stress in Mexican Smokers: A Randomized Clinical Trial

“…Zeolites are a group of aluminosilicates that exhibit diverse biological activities and have found uses as adjuvant therapy in anticancer therapy, adjuvant for vaccines, treatment of heartburn, and as antidiarrheal agents [8][9][10][11][12][13][14][15][16][17] . Natural zeolites are hydrated porous volcanic microcrystals formed mainly of AlO 4 and SiO 4 , which have defined shapes resulting from tetrahedral building blocks connected through O 2 atoms.…”