Zero-crossing derivative spectrophotometry for the determination of haloperidol in presence of parabens

Ouanês, S; Kallel, M.; Trabelsi, H.; Safta, Fathi; Bouzouita, K

doi:10.1016/s0731-7085(97)00174-x

Cited by 22 publications

(12 citation statements)

References 7 publications

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“…Therefore, the determination of trace amounts of HP ion in biological fluids is necessary. Several analytical methods have been reported for the assay of haloperidol including capillary electrophoresis (17), acidimetric titration in non-aqueous medium (18), uV spectrophotometry (19)(20)(21), derivative spectrophotometry (22), colorimetry (23), H-nuclear magnetic resonance spectroscopy (24), densitometry (25), gas chromatography (gC) with electron-capture detection (26) gC with surface ionization detection (27), liquid chromatography (lC) with electrochemical detection (28), lC with uV detection (29), gas-lC with nitrogen-phosphorus detection (30,31), lC with mass spectrometric (MS) detection (32,33), high-performance liquid chromatography (HPlC) with diode array detection (34), HPlC with uV-VIS detection (35,36), micellar electrokinetic chromatography (37), voltammetry (38) and potentiometry (3). These methods are highly sensitive.…”

Section: Introductionmentioning

confidence: 99%

Determination of haloperidol drug in ampoules and in urine samples using a potentiometric PVC-membrane and graphite coated wire electrodes

Shawish¹,

Tamous²,

Shaheen³

et al. 2016

Marmara Pharmaceutical Journal

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Section: Introductionmentioning

confidence: 99%

Determination of haloperidol drug in ampoules and in urine samples using a potentiometric PVC-membrane and graphite coated wire electrodes

Shawish¹,

Tamous²,

Shaheen³

et al. 2016

Marmara Pharmaceutical Journal

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“…Some HPLC [13 -15], spectrophotometric [16], and a few high performance thin-layer chromatography (HPTLC) [17 -18] methods have been used to determine haloperidol in dosage forms. The official method for the quantitative determination of haloperidol in injectables is by spectrophotometry [2].…”

Section: Introductionmentioning

confidence: 99%

Chemical stability of haloperidol injection by high performance thin‐layer chromatography

Mennickent

Pino

Sierra

et al. 2008

J of Separation Science

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The chemical stability of haloperidol lactate injection was studied under different storage conditions by high performance thin-layer chromatography (HPTLC). The study was performed at 25 +/- 2 degrees C and at refrigeration temperature (8 +/- 1 degrees C) in original glass ampoules over 15 days after being opened. The samples tested at 25 +/- 2 degrees C were stored with exposure to and protection from light. Chromatographic separation was achieved on precoated silica gel F 254 HPTLC plates using a mixture of acetone/chloroform/n-butanol/glacial acetic acid/water (5:10:10:2.5:2.5, v/v/v/v/v) as a mobile phase. Quantitative analyses were carried out at a wavelength of 254 nm. The method exhibited adequate linearity (r = 0.999), selectivity, precision (RSD = 1.92%), and accuracy (recoveries from 98.59 to 101.90%). The concentrations of all samples remained greater than or 90% of the original concentration. Haloperidol lactate injection was chemically stable under all conditions studied over 15 days.

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“…Various methods for its determination in pharmaceuticals are available, such as: acidemitric titration in non-aqueous media [3], fluorimetry [4], colorimetry [5 7], polarography [8], liquid chromatography [9 11], derivative spectrophotometry [12] and nuclear magnetic resonance spectroscopy [13].…”

Section: Introductionmentioning

confidence: 99%

Stability—Indicating assay for haloperidol syrup by high-performance liquid chromatography

2001

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SummaryA Snycler selectivity triangle was approved for the optimization of a reversed-phases HPLC separation of halopericlol, methylparaben and propylparaben in the presence of their clegradation products. The degradation products considered were: 4-(4-chlorophenyl)-4-hyclroxypipericline and 4-fluorobenzoic acid presumed to be hydrolytic products of halopericlol, and 4-hyclroxybenzoic presumed to be a hydrolytic product of parabens.Separation was achieved on an octaclecyl silica column using a mobile phase of methanol, phosphate buffer (pH 2.0) and triethylamine (50:50:0.2) with UV detection at 254 nm. The proposed method was verified for linearif,/, specifici N accuracy and reproducibility. The stabihty-inclicating capabihty of the assay was proved by conducting forced degradation conditions of light and temperature on a commercial drug product, for the stabihty investigation of the active ingredient and preservatives. It was successfully used to proceed the degradation kinetics of the drug uncler several storage conditions.

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Zero-crossing derivative spectrophotometry for the determination of haloperidol in presence of parabens

Cited by 22 publications

References 7 publications

Determination of haloperidol drug in ampoules and in urine samples using a potentiometric PVC-membrane and graphite coated wire electrodes

Determination of haloperidol drug in ampoules and in urine samples using a potentiometric PVC-membrane and graphite coated wire electrodes

Chemical stability of haloperidol injection by high performance thin‐layer chromatography

Stability—Indicating assay for haloperidol syrup by high-performance liquid chromatography

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