Zero waste multistage utilization of Ginkgo biloba branches

Ma, Jie; Ling, Nyuk; Zhang, Dangquan; Wu, Ningpeng; Li, Xue; Li, Meng; Ma, Dongli; Gao, Xinya; Chu, Zhiqiang; Zhang, Panpan; Li, Mingwan

doi:10.1016/j.chemosphere.2021.133345

Cited by 14 publications

(6 citation statements)

References 54 publications

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“…However, GBE composition may vary across studies, largely dependent on the complicated extraction procedure ( Fang et al, 2020b ; Boateng, 2022 ; Liu et al, 2022 ; Ma et al, 2022 ).…”

Section: Discussionmentioning

confidence: 99%

“…Subsequent research is hindered by the mixture nature of GBE and its multi-target effects. A complicated extraction procedure is required to obtain bioactive components from GBE ( Liu et al, 2022 ; Ma et al, 2022 ), and the procedure is still ongoing improvement ( Boateng, 2022 ). The variability of extracts results in difficulty in repeating results across studies, thereby hampering the exploration of molecular mechanisms.…”

Section: Introductionmentioning

confidence: 99%

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Uncovering the pharmacology of Ginkgo biloba folium in the cell-type-specific targets of Parkinson’s disease

Yan

Wang

et al. 2022

Front. Pharmacol.

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Parkinson’s disease (PD) is the second most common neurodegenerative disease with a fast-growing prevalence. Developing disease-modifying therapies for PD remains an enormous challenge. Current drug treatment will lose efficacy and bring about severe side effects as the disease progresses. Extracts from Ginkgo biloba folium (GBE) have been shown neuroprotective in PD models. However, the complex GBE extracts intertwingled with complicated PD targets hinder further drug development. In this study, we have pioneered using single-nuclei RNA sequencing data in network pharmacology analysis. Furthermore, high-throughput screening for potent drug-target interaction (DTI) was conducted with a deep learning algorithm, DeepPurpose. The strongest DTIs between ginkgolides and MAPK14 were further validated by molecular docking. This work should help advance the network pharmacology analysis procedure to tackle the limitation of conventional research. Meanwhile, these results should contribute to a better understanding of the complicated mechanisms of GBE in treating PD and lay the theoretical ground for future drug development in PD.

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“…However, GBE composition may vary across studies, largely dependent on the complicated extraction procedure ( Fang et al, 2020b ; Boateng, 2022 ; Liu et al, 2022 ; Ma et al, 2022 ).…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Uncovering the pharmacology of Ginkgo biloba folium in the cell-type-specific targets of Parkinson’s disease

Yan

Wang

et al. 2022

Front. Pharmacol.

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“…The minimum inhibitory concentration (MIC) of the EOs was determined by the twofold broth dilution method. The EOs were diluted multiply with a liquid medium to obtain a series of gradient concentration samples (0.25 mg/mL, 0.5 mg/mL, 1 mg/mL, 2 mg/mL, 4 mg/mL, 8 mg/mL, 16 mg/mL, 32 mg/mL, 64 mg/mL, 128 mg/mL), and the minimum bactericidal concentration (MBC) was determined based on the results of MIC was further determined [32] …”

Section: Methodsmentioning

confidence: 99%

Contribution of Constituents in Rosemary‐Magnolia Compound Essential Oil to Antibacterial, Antioxidant and Cytotoxicity Bioactivities Revealed by Grey Correlation Analysis

Song

Zhang

Jin³

et al. 2023

Chemistry & Biodiversity

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The compound of essential oils (EOs) is a key approach to achieving the superimposed efficacy of plant EOs. In this article, grey correlation analysis was applied for the first time to explore the compound ratios and contribution between constituents and the bioactivity of the compound EOs. There were 12 active constituents shared in rosemary and magnolia EOs prepared by negative pressure distillation. With different proportions, these two EOs were blended and analyzed for the antioxidant, bacteriostatic and antitumor effects. According to the results of the inhibition circle, minimum bactericidal and inhibitory concentration, the most obvious inhibition effect of the compound EOs on different strains of bacteria was shown in Staphylococcus aureus. The results of antioxidant test showed that single EO from rosemary had the best antioxidant effect, and its EO content was directly proportional to the antioxidant effect. The cytotoxicity results showed that, there was a significant difference in the lethality of the compound EOs between tumor cells Mcf-7 (human breast cancer cells) and SGC-7901 cells (human gastric cancer cells). Furthermore, single EO from magnolia had an obvious inhibitory effect on the growth of Mcf-7 cells and SGC-7901 cells, and the cell lethality rate was as high as 95.19 % and 97.96 %, respectively. As the results of grey correlation analysis, the constituents with the maximal correlation of inhibitory effects on bacteria were as follows: S. aureus -Terpinolene (0.893), E. coli -Eucalyptol (0.901), B. subtilis -α-Pinene (0.823), B. cereus -Terpinolene (0.913) and Salmonella -α-Phellandrene (0.855). For the ABTS and DPPH scavenging effects, the constituents with the maximal correlation were (À )-Camphor (0.860) and β-Pinene (0.780), respectively. In terms of the effects of the active constituents of compound EOs on the inhibitory activities of tumor cells Mcf-7 and SGC-7901, the three active constituents of γ-Terpinene, (R)-(+)-β-Citronellol and (À )-Camphor were in the top three, and their correlation were Mcf-7 (0.833, 0.820, 0.795) and SGC-7901 (0.797, 0.766, 0.740). Our study determined the contribution degree of active constituents in the antibacterial, antioxidant, and antitumor bioactivities of rosemarymagnolia compound EOs, and also provided new insights for the research of EOs combination formulations.

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“…However, the rough processing method restricts the use of cottonseed and results in low comprehensive benefits. Converting biomass into biobased materials can sequester the CO 2 fixed by plants and thus is a carbon-negative biomaterial utilization mode [2] . It has been reported that cotton seed hulls can also be prepared into various forms of porous carbon materials, which have broad application prospects in new types of energy and in environmental protection [3] , [4] .…”

Section: Introductionmentioning

confidence: 99%

Sustainable conversion of cottonseed hulls to valuable proanthocyanidins through ultrasound-assisted deep eutectic solvent extraction

Cui,

Fang,

Tian

et al. 2023

Ultrasonics Sonochemistry

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Zero waste multistage utilization of Ginkgo biloba branches

Cited by 14 publications

References 54 publications

Uncovering the pharmacology of Ginkgo biloba folium in the cell-type-specific targets of Parkinson’s disease

Uncovering the pharmacology of Ginkgo biloba folium in the cell-type-specific targets of Parkinson’s disease

Contribution of Constituents in Rosemary‐Magnolia Compound Essential Oil to Antibacterial, Antioxidant and Cytotoxicity Bioactivities Revealed by Grey Correlation Analysis

Sustainable conversion of cottonseed hulls to valuable proanthocyanidins through ultrasound-assisted deep eutectic solvent extraction

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