Zeta potential changing nanoemulsions based on a simple zwitterion

Sharifi, Faezeh; Jahangiri, Mansour; Nazir, Imran; Asim, Mulazim Hussain; Ebrahimnejad, Pedram; Hupfauf, Andrea; Gust, Ronald; Bernkop‐Schnürch, Andreas

doi:10.1016/j.jcis.2020.11.054

Cited by 40 publications

(23 citation statements)

References 28 publications

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“…Alternatively, Sharifi et al synthesized comparatively small surfactants containing on the one head a phosphate group and on the other head a primary amino group by phosphorylation of 12-aminododecanol with phosphorus pentoxide (12-AD) [222] and by phosphorylation of tyramine using phosphorus chloride. [223]…”

Section: Flip-flop Lipidsmentioning

confidence: 99%

“…[221] The charge conversion upon ALP treatment was also reported for SEDDS containing a Janus-headed flip-flop surfactant (phosphorylated 12-amino-dodecanol, 12-AD) [222] and zwitterionic flip-flop surfactant loaded nanoemulsions. [223] The composition of SEDDS and nanoemulsions is also crucial in terms of the proper positioning of phosphate groups on the surface for an effective enzymatic cleavage. Most SEDDS contain PEG-based emulsifiers such as polysorbates or polyethoxylated castor oil.…”

Section: Charge Converting Delivery Systemsmentioning

confidence: 99%

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Alkaline Phosphatase: A Reliable Endogenous Partner for Drug Delivery and Diagnostics

Le‐Vinh

Akkuş‐Dağdeviren

et al. 2022

Advanced Therapeutics

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Since the 1960s the membrane-bound enzyme alkaline phosphatase (ALP) has been utilized in drug delivery. As it cleaves phosphate substructures from drugs, auxiliary agents, and even from the surface of nanocarriers, this enzyme enables the design of drug delivery systems that can alter their properties in the body on demand. Anionic nanocarriers exhibiting bioinert properties can alter their surface to interactive once having reached the target site as due to an ALP-triggered cleavage of anionic phosphate groups from their surface charge converts to cationic improving for instance cellular uptake. Moreover, features such as the accumulation of nanocarriers at the target site or a targeted drug release triggered by ALP can be introduced. In addition, ALP is utilized to improve the potential of numerous diagnostic systems. Within this review, one provides an overview about the activity, selectivity, and distribution of this enzyme, as well as the great variety of applications in drug delivery and diagnostics making use of it.

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Section: Flip-flop Lipidsmentioning

confidence: 99%

Section: Charge Converting Delivery Systemsmentioning

confidence: 99%

Alkaline Phosphatase: A Reliable Endogenous Partner for Drug Delivery and Diagnostics

Le‐Vinh

Akkuş‐Dağdeviren

et al. 2022

Advanced Therapeutics

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“…Accumulation of BNPs into cells could be aided by the hydrophilic PEG surface coating leading to pinocytosis by the cells; these negatively charged BNPs may permeate more rapidly across the cell membrane layer due to electrostatic repulsion from the negative charge. 57 Once BNPs enters cells, it splits and release of Ag occurs, resulting in greater toxicity. Usually, solutions containing Ag-NPs, zero-valent silver (Ag°) sometimes occur with forms of ionic Ag, which is due to partial reduction of precursors or oxidation of silver NPs to release Ag+ ions.…”

Section: Resultsmentioning

confidence: 99%

One Pot Synthesis of PEGylated Bimetallic Gold–Silver Nanoparticles for Imaging and Radiosensitization of Oral Cancers

Ahmed¹,

Baijal

Somashekar³

et al. 2021

IJN

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Background:Radiotherapy is an important treatment modality for many types of head and neck squamous cell carcinomas. Nanomaterials comprised of high atomic number (Z) elements are novel radiosensitizers enhance radiation injury by production of free radicals and subsequent DNA damage. Gold nanoparticles are upcoming as promising radiosensitizers due to their high (Z) biocompatibility, and ease for surface engineering. Bimetallic nanoparticles have shown enhanced anticancer activity compared to monometallic nanoparticles. Materials and Methods: PEG-coated Au-Ag alloy nanoparticles (BNPs) were synthesized using facile one pot synthesis techniques. Size of ~50±5nm measured by dynamic light scattering. Morphology, structural composition and elemental mapping were analyzed by electron microscopy and SAXS (small-angle X-ray scattering). The radiosensitization effects on KB oral cancer cells were evaluated by irradiation with 6MV X-rays on linear accelerator. Nuclear damage was imaged using confocal microscopy staining cells with Hoechst stain. Computed tomography (CT) contrast enhancement of BNPs was compared to that of the clinically used agent, Omnipaque. Results: BNPs were synthesized using PEG 600 as reducing and stabilizing agent. The surface charge of well dispersed colloidal BNPs solution was −5mV. Electron microscopy reveals spherical morphology. HAADF-STEM and elemental mapping studies showed that the constituent metals were Au and Ag intermixed nanoalloy. Hydrodynamic diameter was ~50±5nm due to PEG layer and water molecules absorption. SAXS measurement confirmed BNPs size around 35nm. Raman shift of around 20 cm −1 was observed when BNPs were coated with PEG. 1 H NMR showed extended involvement of − OH in synthesis. BNPs efficiently enter cytoplasm of KB cells and demonstrated potent in vitro radiosensitization with enhancement ratio ~1.5-1.7. Imaging Hoechst-stained nuclei demonstrated apoptosis in a dose-dependent manner. BNPs exhibit better CT contrast enhancement ability compared to Omnipaque. Conclusion: This bimetallic intermix nanoparticles could serve a dual function as radiosensitizer and CT contrast agent against oral cancers, and by extension possibly other cancers as well.

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“…They are all negative electric suspension systems. 54) With increase of Ag concentration, the zeta potential becomes more negative. Generally, the surface with more high negative charge is favorable for adsorption of extracellular matrix and Ca 2+ ions, which can promote adhesion of bone cells and enhance the bioactivity of nanoparticles.…”

Section: Chemical Composition Analysismentioning

confidence: 99%

Synthesis of silver modified hydroxyapatite nanoparticle and evaluation of its biological properties <i>in vitro</i> for potential biomedical application

Wang

Zhao

et al. 2021

J. Ceram. Soc. Japan

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In order to impart nano hydroxyapatite (HA) more biological functions and develop its potential application in biomedical field, silver modified hydroxyapatite (Ag-HA) nanoparticles were synthesized via solgel method. The powders were sintered at 600°C for 1 h. The microstructures, morphologies and chemical compositions of HA and Ag-HA were investigated by X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), X-ray photoelectron spectroscopy (XPS), High resolution transmission electron microscopy (HR-TEM), Scanning electron microscopy (SEM) and Energy dispersive X-ray spectroscopy (EDS). The results indicate that Ag modification has a certain effect on the microstructure, morphology and Zeta potential of HA. The hemocompatibility of HA and Ag-HA with different doses were evaluated by lots of hemolytic tests. The results indicate that pure HA performs non-hemolytic activity at the dose range of 202000¯g/cm 3 . Due to the appearance of Ag, the hemocompatibility of Ag-HA with different Ag concentration show obvious differences. The Ag-HA with concentration of 0.5 mol % Ag (0.5Ag-HA) has better hemocompatibility, its hemolytic ratio is less than 5 % when its usage dose is up to 1000¯g/cm 3 . But Ag-HA with concentration of 1.0 mol % and 1.5 mol % Ag (1.0Ag-HA and 1.5Ag-HA) show non-hemolytic property only lower doses. The antibacterial ratio of 0.5Ag-HA against Streptococcus mutans is up to 99 % only the dose of 400¯g/cm 3 . The biological evaluation further confirmed the safe dose of the antibacterial HA nanoparticles for its application in biomedical field.

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Zeta potential changing nanoemulsions based on a simple zwitterion

Cited by 40 publications

References 28 publications

Alkaline Phosphatase: A Reliable Endogenous Partner for Drug Delivery and Diagnostics

Alkaline Phosphatase: A Reliable Endogenous Partner for Drug Delivery and Diagnostics

One Pot Synthesis of PEGylated Bimetallic Gold–Silver Nanoparticles for Imaging and Radiosensitization of Oral Cancers

Synthesis of silver modified hydroxyapatite nanoparticle and evaluation of its biological properties <i>in vitro</i> for potential biomedical application

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