ZIF-8 integrated with polydopamine coating as a novel nano-platform for skin-specific drug delivery

Wang, Qiuyue; Li, Mingming; Sun, Xinxing; Chen, Naiying; Yao, Sicheng; Feng, Xun; Yang, Chen

doi:10.1039/d2tb02361j

Cited by 8 publications

(8 citation statements)

References 73 publications

(116 reference statements)

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“…Considering the positive ζ potential of PCN-224, its electrostatic interaction with the negatively charged skin surface could potentially disrupt the integrity of the stratum corneum, as demonstrated in our previous study. 26 Such electrostatic interactions might facilitate the traversal of these nanoparticles across the dense barrier of the stratum corneum, and thus, the particle size would become a determining factor influencing penetration depth.…”

Section: Penetration Behaviors Of the Three-sized Pcn-224 In The Skinmentioning

confidence: 99%

“…22−25 In the previous study, we demonstrated the feasibility of MOFs for improved dermal drug delivery by using zeolite imidazole framework-8 (ZIF-8) as a carrier of 5fluorouracil. 26 However, the research on the utilization of PCN-224 as a dermal or transdermal drug delivery carrier has been rarely realized and reported. Considering the possible insufficiency of the sole sensitizer, 27 it would be quite interesting to incorporate other kinds of sensitizers in PCN-224 for possible combined sonodynamic efficacy.…”

Section: Introductionmentioning

confidence: 99%

“…Due to the porous structure and functional surface of MOFs, PCN-224 is also promising for use as the drug delivery host. − In the previous study, we demonstrated the feasibility of MOFs for improved dermal drug delivery by using zeolite imidazole framework-8 (ZIF-8) as a carrier of 5-fluorouracil . However, the research on the utilization of PCN-224 as a dermal or transdermal drug delivery carrier has been rarely realized and reported.…”

Section: Introductionmentioning

confidence: 99%

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Porphyrinic Metal–Organic Framework PCN-224 Nanoparticles for Colocalization of Nanoparticle-Cargo in the Skin and Enhancement of Sonodynamic Efficacy

Sun,

Wang,

Bao

et al. 2024

ACS Appl. Nano Mater.

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Sonodynamic therapy (SDT) is a novel therapeutic modality that is effective for the noninvasive treatment of dermatological diseases. As a ubiquitous large class of sonosensitizers, however, porphyrins suffer from poor skin permeability and the inefficient generation of reactive oxygen species. Herein, different-sized porphyrinic metal−organic frameworks (MOFs), 125, and 200 nm), were developed via the coordination of tetra-kis(4-carboxyphenyl) porphyrin (TCPP) and the metal zirconium to enhance the local delivery of porphyrins, and fluorescent sonosensitizers (methylene blue or rhodamine 6G) were further incorporated to improve the sonodynamic effect, as well as to visualize the delivery of PCN-224 and its cargo. The skin penetration of PCN-224 was found to be increased with the reduction of particle size, and all three-sized samples could overcome the barrier of stratum corneum, even achieving the dermis of the porcine skin. Both intercellular and follicular pathways were noticed for three-sized PCN-224, while the follicular one played a more significant role in the penetration of the smallest PCN-224. The intact nanoparticles were found in the skin. At the initial stage, the nanoparticle and its cargo penetrated the skin as an intact entity, while the encapsulated rhodamine 6G was slowly released to the microenvironment of the skin from the nanoparticle with the prolongation of application. The combination of PCN-224 and methylene blue could increase the acoustically triggered generation of 1 O 2 , distinctly boosting the lethal effect against the cancerous cell. Collectively, the study revealed the feasibility of PCN-224 for topical use, suggested an innovative method to enhance the sonodynamic effect, and proposed a possible mechanism for skin drug delivery of MOFs.

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Section: Penetration Behaviors Of the Three-sized Pcn-224 In The Skinmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Porphyrinic Metal–Organic Framework PCN-224 Nanoparticles for Colocalization of Nanoparticle-Cargo in the Skin and Enhancement of Sonodynamic Efficacy

Sun,

Wang,

Bao

et al. 2024

ACS Appl. Nano Mater.

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“…12) Recently, Wang et al coated ZIF-8 with dopamine to improve the skin targeting of 5-fluorouracil and facilitate drug delivery to deeper sites with the help of the hair follicle pathway. 141 In addition, other emerging inorganic NPs, such as metalorganic frameworks (MOF), and quantum dots (QDs), are flourishing. MOFs are mainly crystals composed of organic chains and metal ions.…”

Section: Inorganic-based Npsmentioning

confidence: 99%

Section: Classifications Of Nps For Intracellular Cargo Deliverymentioning

confidence: 99%

Design and fabrication of intracellular therapeutic cargo delivery systems based on nanomaterials: current status and future perspectives

Xing

Zhou

et al. 2023

J. Mater. Chem. B

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Incorporating Fluorescent Organosilica and Zeolitic Imidazolate Frameworks into Periodic Mesoporous Organosilica for the Enhanced Cargo Delivery of 5‐Fluorouracil

Huynh,

Nguyen,

Mai

et al. 2024

ChemistrySelect

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Nanosized zeolitic imidazolate frameworks (nZIFs) are being researched as 5‐fluorouracil (5‐FU) carriers for the treatment of cancer. The surface functionalization of ZIFs with periodic mesoporous organosilicas (PMOs) is expected to enhance stability and prevent the flocculation of nZIFs. In this study, ZIF‐7 nanomaterials and fluorescent organosilicas (FITC−APTES) were effectively introduced into PMO nanoparticles, and the resulting product was named ZIF‐7@PMO. The surface functionalization with the PMO nanoparticles enhanced the chemical stability of ZIF‐7 nanoparticles in ethanol. The study examined the impact of temperature on the synthesis of ZIF‐7@PMO and found that low temperatures were more conducive to the encapsulation of ZIF‐7 nanoparticles and fluorescent organosilica, as well as pore size retention. Moreover, the drug storage capacity of the ZIF‐7@PMO nanoparticles was evaluated via their loading and release of 5‐FU. The results revealed that the ZIF‐7@PMO nanoparticles could adsorb 5‐FU with a loading capacity of 100–140 mg g−1 for 24 h. ZIF‐7@PMO released half of 5‐FU amount within 8 h before releasing a maximum of 75 % within 3 days. Therefore, the fluorescent ZIF‐7@PMO nanoparticles could be a potential drug carrier in the field of controlled drug delivery.

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ZIF-8 integrated with polydopamine coating as a novel nano-platform for skin-specific drug delivery

Abstract: Metal-organic frameworks (MOFs) are highly promising as a novel kind of drug delivery carrier; however, there are few reports about their application in nanoparticle-based formulations for dermal administration. In this...

Cited by 8 publications

References 73 publications

Porphyrinic Metal–Organic Framework PCN-224 Nanoparticles for Colocalization of Nanoparticle-Cargo in the Skin and Enhancement of Sonodynamic Efficacy

Porphyrinic Metal–Organic Framework PCN-224 Nanoparticles for Colocalization of Nanoparticle-Cargo in the Skin and Enhancement of Sonodynamic Efficacy

Design and fabrication of intracellular therapeutic cargo delivery systems based on nanomaterials: current status and future perspectives

Incorporating Fluorescent Organosilica and Zeolitic Imidazolate Frameworks into Periodic Mesoporous Organosilica for the Enhanced Cargo Delivery of 5‐Fluorouracil

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