The current outbreak of Zika virus infections is particularly alarming because infection during pregnancy can lead to severe brain damage in the developing fetus. There are currently no anti-viral therapies being provided to Zika virus infected pregnant women. Methods are available to enhance the alternative cellular energy (ACE) pathway as a non-immunological anti-virus defense mechanism. Benefits of these therapies have been described in patients infected with herpes simplex virus (HSV), herpes zoster virus (HZV), human papillomaviruses (HPV) and human immunodeficiency virus (HIV). ACE pathway based therapies are particularly important in suppressing infections with stealth adapted viruses, which are not effectively recognized by the cellular immune system. As proposed elsewhere, co-infection with stealth adapted viruses may help explain the transplacental passage of the Zika virus into fetal tissues. Drinking water that has been activated with KELEA (kinetic energy limiting electrostatic attraction) can potentially provide a safe and effective means of enhancing the ACE pathway. Clinical trials using this and other approaches to stimulate the ACE pathway should be evaluated in Zika virus infected patients, including pregnant women. Zika virus infected mothers with brain damaged infants should also be tested for co-infection with stealth adapted viruses.