Zika Virus Associated with Meningoencephalitis

Carteaux, Guillaume; Maquart, Marianne; Bedet, Alexandre; Contou, Damien; Brugières, Pierre; Fourati, Slim; Langavant, Laurent Cléret de; Broucker, T. de; Brun‐Buisson, Christian; Leparc-Goffart, Isabelle; Dessap, Armand Mekontso

doi:10.1056/nejmc1602964

Cited by 444 publications

(349 citation statements)

References 4 publications

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“…The rapid spread of ZIKV within the Americas has unveiled microcephaly 1 and Guillain-Barré syndrome 2,3 as ZIKV-associated neurological complications. Recent reports have further indicated other neurological manifestations to be associated with ZIKV including myelitis 4 , meningoencephalitis 5 and fatal encephalitis 6 . Here, we investigate the neuropathogenesis of ZIKV infection in IFNAR knockout ( Ifnar1 −/− ) mice, an infection model that exhibits high viral burden within the central nervous system (CNS).…”

mentioning

confidence: 99%

Antiviral CD8 T cells induce Zika-virus-associated paralysis in mice

et al. 2017

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Zika virus (ZIKV) is an emerging, mosquito-borne RNA virus. The rapid spread of ZIKV within the Americas has unveiled microcephaly1 and Guillain-Barré syndrome 2,3 as ZIKV-associated neurological complications. Recent reports have further indicated other neurological manifestations to be associated with ZIKV including myelitis 4, meningoencephalitis 5 and fatal encephalitis6. Here, we investigate the neuropathogenesis of ZIKV infection in IFNAR knockout (Ifnar1−/−) mice, an infection model that exhibits high viral burden within the central nervous system (CNS). We show that systemic spread of ZIKV from the site of infection to the brain requires Ifnar1-deficiency in the hematopoietic compartment. However, spread of ZIKV within the CNS is supported by Ifnar1-deficient non-hematopoietic cells. Within this context, ZIKV infection of astrocytes results in breakdown of the blood-brain barrier and a large influx of CD8+ effector T cells. Further, we find antiviral activity of CD8+ T cells within the brain markedly limits ZIKV infection of neurons, but as a consequence instigates ZIKV-associated paralysis. Taken together, our study uncovers mechanisms underlying ZIKV-neuropathogenesis within a susceptible mouse model and suggests BBB breakdown and T cell mediated neuropathology as potential underpinnings of ZIKV-associated neurological complications in humans.

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confidence: 99%

Antiviral CD8 T cells induce Zika-virus-associated paralysis in mice

et al. 2017

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“…It has been know since 1960-1970 that CHIKV can affect the central nervous system. Myelitis, when present, is usually associated with encephalitis 2,31 . Guillain-Barré syndrome, optic neuritis, facial paralysis, acute disseminated encephalomyelitis, peripheral neuropathy, and myopathy have also been described in CHIKV infection 2,32,33,34 .…”

Section: Warning Of Neurological Complications Of Dengue Zika and Cmentioning

confidence: 99%

“…The ZIKV has been found by culture or reverse transcriptase polymerase chain reaction during the first days of infection 27,31,35 . Detection of specific IgM antibodies or increased titer of specific IgG in serum occurs 5-10 days after onset of symptoms and persists for many weeks to three months.…”

Section: Laboratory Diagnosismentioning

confidence: 99%

Dengue infection in the nervous system: lessons learned for Zika and Chikungunya

Puccioni-Sohler

Roveroni

Rosadas

et al. 2017

Arq. Neuro-Psiquiatr.

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Dengue, Zika and Chikungunya are emerging arboviruses and important causes of acute febrile disease in tropical areas. Although dengue does not represent a new condition, a geographic expansion over time has occurred with the appearance of severe neurological complications. Neglect has allowed the propagation of the vector (Aedes spp), which is also responsible for the transmission of other infections such as Zika and Chikungunya throughout the world. The increased number of infected individuals has contributed to the rise of neurological manifestations including encephalitis, myelitis, meningitis, Guillain-Barré syndrome and congenital malformations such as microcephaly. In this narrative review, we characterize the impact of the geographic expansion of the vector on the appearance of neurological complications, and highlight the lack of highly accurate laboratory tests for nervous system infections. This represents a challenge for public health in the world, considering the high number of travelers and people living in endemic areas.

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“…Laboratory findings were the same as described (87) for Zika virusassociated transverse myelitis. Other neurological consequences of Zika virus infection in the adult include a decline in bilateral acuity in hearing, transient dull or metallic hearing, and a delay between the emission and perception of sound.…”

Section: Zika Virus Gbs and Other Neurological Disorders In Adultsmentioning

confidence: 99%

Zika virus: what do we know about the viral structure, mechanisms of transmission, and neurological outcomes?

Silva

Souza

2016

Rev. Soc. Bras. Med. Trop.

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The Zika virus epidemic that started in Brazil in 2014 has spread to >30 countries and territories in Latin America, leading to a rapid rise in the incidence of microcephalic newborns and adults with neurological complications. At the beginning of the outbreak, little was known about Zika virus morphology, genome structure, modes of transmission, and its potential to cause neurological malformations and disorders. With the advancement of basic science, discoveries of the mechanisms of strain variability, viral transfer to the fetus, and neurovirulence were published. These will certainly lead to the development of strategies to block vertical viral transmission, neuronal invasion, and pathogenesis in the near future. This paper reviews the current literature on Zika virus infections, with the aim of gaining a holistic insight into their etiology and pathogenesis. We discuss Zika virus history and epidemiology in Brazil, viral structure and taxonomy, old and newly identified transmission modes, and neurological consequences of infection.

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Zika Virus Associated with Meningoencephalitis

Cited by 444 publications

References 4 publications

Antiviral CD8 T cells induce Zika-virus-associated paralysis in mice

Antiviral CD8 T cells induce Zika-virus-associated paralysis in mice

Dengue infection in the nervous system: lessons learned for Zika and Chikungunya

Zika virus: what do we know about the viral structure, mechanisms of transmission, and neurological outcomes?

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