2018
DOI: 10.1007/s00109-018-1692-z
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Zika virus infection and implications for kidney disease

Abstract: High-level and persistent viruria observed in patients infected by Zika virus (ZIKV) has been well documented. However, renal pathology in acutely infected, immunocompetent patients remains subclinical. Moreover, the long-term impact of ZIKV infection, replication, and persistence in the renal compartment of adults and infants as well as immunosuppressed patients and solid organ transplant (SOT) recipients is unknown. Mechanisms involving host and viral factors that limit or control ZIKV pathogenesis in the re… Show more

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Cited by 19 publications
(8 citation statements)
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“…Persistent shedding of ZIKV RNA in patients infected by ZIKV has been well described [80][81][82]. However, renal pathology, if present, remains subclinical at least in immunocompetent patients.…”
Section: Zika In Adultsmentioning
confidence: 99%
“…Persistent shedding of ZIKV RNA in patients infected by ZIKV has been well described [80][81][82]. However, renal pathology, if present, remains subclinical at least in immunocompetent patients.…”
Section: Zika In Adultsmentioning
confidence: 99%
“…It is known that the Zika virus has an effect on the glomerulus in animal models, and although the virus is continuously found in urine, there is no study on the effect of the virus on UTIs [11].…”
Section: Infectious Viruses Found In Urine 1 Zika Virusmentioning
confidence: 99%
“…Kidney has been recognized as a target for various flaviviruses including ZIKV [ 12 ]. Detection of viral RNA in urine up to two weeks after acute ZIKV infection has been reported [ 13 ]. Such findings sustain the hypothesis that the kidney could contribute to the pathophysiology of ZIKV infection as a potential viral reservoir.…”
Section: Introductionmentioning
confidence: 99%