Zinc Alginate Beads for the Controlled Release of Rifampicin

Deepathomas, Deepathomas; Latha, M.S.; KurienThomas, K.

doi:10.13005/ojc/340146

Cited by 7 publications

(4 citation statements)

References 9 publications

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“…This was due to the increase of negatively charged of carboxylate ions because of a higher level of ionization. These carboxylate ions might repel each other and cause the disaggregating of the alginate-CaCl 2 matrix structure, then lead to swollen microcapsules [42]. This result was also supported by the SEM image in Fig.…”

Section: ■ Results and Discussionsupporting

confidence: 64%

Microencapsulation of <i>Ruellia tuberosa</i> L. Extracts Using Alginate: Preparation, Biological Activities, and Release

et al. 2023

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The bioactive compounds naturally present in plants have great importance due to their biological characteristics. These substances could lose their active characteristics since they are highly unstable. Microencapsulation is one of the techniques to improve stability and protect these compounds. In this work, Ruellia tuberosa L. ethanolic extracts microcapsules were prepared using a freeze-drying method by varying pH, alginate concentration, and stirring time. The encapsulation efficiency (EE), characteristics, alpha-amylase inhibition activity, and release behavior of the microcapsules were investigated. The results highlighted that the highest encapsulation efficiency for the microcapsules was obtained at pH 6, alginate concentration of 1% (w/v), and 30 min of stirring time (51.63% EE). The microcapsules mostly had spherical shapes with a mean diameter of 197.53 μm. The alpha-amylase inhibition assay from microcapsules resulted in the IC50 value of 46.66 ± 0.13 μg/mL, demonstrating high biological activity. The bioactive substances from microcapsules were released during intervals of 30–120 min at pH values of 1.2 and 7.4. Only 3.51% of the bioactive substances were released at pH 1.2 after 120 min, compared to 55.78% at pH 7.4. Overall, this work confirms the possibility of developing plant extracts with preserved biological activity using the produced microcapsules.

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Section: ■ Results and Discussionsupporting

confidence: 64%

Microencapsulation of <i>Ruellia tuberosa</i> L. Extracts Using Alginate: Preparation, Biological Activities, and Release

et al. 2023

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“…In order to minimize the statistical error, all experiments were done in triplicate. For the dissolution tests of pH-responsive analysis, due to the evaluation of the controlled release behavior of paracetamol in the carboxylated lignin formulation, two different pHs were considered: phosphate buffer solution, pH = 7.2 (intestine environment) and acidic buffer solution (0.1 N HCL), pH = 1.2 (gastric environment) [40,41].…”

Section: Methodsmentioning

confidence: 99%

Design of Controlled Release System for Paracetamol Based on Modified Lignin

et al. 2019

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The influence of lignin modification on drug release and pH-dependent releasing behavior of oral solid dosage forms was investigated using three different formulations. The first formulation contains microcrystalline cellulose (MCC 101) as the excipient and paracetamol as the active pharmaceutical ingredient (API). The second formulation includes Alcell lignin and MCC 101 as the excipient and paracetamol, and the third formulation consists of carboxylated Alcell lignin, MCC 101 and paracetamol. Direct compaction was carried out in order to prepare the tablets. Lignin can be readily chemically modified due to the existence of different functional groups in its structure. The focus of this investigation is on lignin carboxylation and its influence on paracetamol control release behavior at varying pH. Results suggest that carboxylated lignin tablets had the highest drug release, which is linked to their faster disintegration and lower tablet hardness.

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“…Zn-alginate beads show excellent biocompatibility and no fatal cytotoxicity when utilized as carriers for RIF administration [155]. Alginate has been employed as a stabilizer in the manufacture of silver nanoparticles, which have the ability to attack M. tuberculosis and sterilize nonreplicating persistent TB [156].…”

Section: Alginate-based Polymer Drug Delivery Systemsmentioning

confidence: 99%

Advanced drug delivery and therapeutic strategies for tuberculosis treatment

Nair,

Greeny,

Nandan

et al. 2023

J Nanobiotechnol

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Tuberculosis (TB) remains a significant global health challenge, necessitating innovative approaches for effective treatment. Conventional TB therapy encounters several limitations, including extended treatment duration, drug resistance, patient noncompliance, poor bioavailability, and suboptimal targeting. Advanced drug delivery strategies have emerged as a promising approach to address these challenges. They have the potential to enhance therapeutic outcomes and improve TB patient compliance by providing benefits such as multiple drug encapsulation, sustained release, targeted delivery, reduced dosing frequency, and minimal side effects. This review examines the current landscape of drug delivery strategies for effective TB management, specifically highlighting lipid nanoparticles, polymer nanoparticles, inorganic nanoparticles, emulsion-based systems, carbon nanotubes, graphene, and hydrogels as promising approaches. Furthermore, emerging therapeutic strategies like targeted therapy, long-acting therapeutics, extrapulmonary therapy, phototherapy, and immunotherapy are emphasized. The review also discusses the future trajectory and challenges of developing drug delivery systems for TB. In conclusion, nanomedicine has made substantial progress in addressing the challenges posed by conventional TB drugs. Moreover, by harnessing the unique targeting abilities, extended duration of action, and specificity of advanced therapeutics, innovative solutions are offered that have the potential to revolutionize TB therapy, thereby enhancing treatment outcomes and patient compliance. Graphical Abstract

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Zinc Alginate Beads for the Controlled Release of Rifampicin

Cited by 7 publications

References 9 publications

Microencapsulation of <i>Ruellia tuberosa</i> L. Extracts Using Alginate: Preparation, Biological Activities, and Release

Microencapsulation of <i>Ruellia tuberosa</i> L. Extracts Using Alginate: Preparation, Biological Activities, and Release

Design of Controlled Release System for Paracetamol Based on Modified Lignin

Advanced drug delivery and therapeutic strategies for tuberculosis treatment

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