Zinc and Copper in Breast Cancer

Magálová, T; Bella, Vladimír; Babinská, Katarína; Brtková, A.; Kudlácková, M; Béderová, A

doi:10.1007/978-1-4899-0167-5_65

Cited by 9 publications

(2 citation statements)

References 8 publications

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“…), что позволяет своевременно провести санитарно-эпидемиологические и профилактические мероприятия. В результате изучения микроэлементного статуса появляется возможность раннего прогнозирования онкологического риска в популяции населения, особенно в зонах с неблагополучной экологической ситуацией и наличием больших промышленных предприятий с вредными условиями производства [3,12,14]. Волосы по сравнению с другими биологическими субстратами депонируют и аккумулируют процессы, длительно протекающие в человеческом организме под воздействием комплекса эколого-физиологических факторов, поэтому анализ их элементного состава может служить средством диагностики и тестом для определения предрасположенности к некоторым заболеваниям, а также позволяет выяснить возможные причины неэффективного лечения.…”

Section: Introductionunclassified

Analysis of the Content of Microelements in Hair in Patients With Breast Cancer

Yusupbekov¹,

Khudaykulov²,

Danilova³

2019

Problems in oncology

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The last 15 years has been actively developing methods of evaluation of trace elements in the human body for the hair analysis. The content of trace elements in hair reflects their level in the human body, and is an integral indicator characterizing his element status. Purpose: study of trace elements in patients with second-stage breast cancer. Object and Methods: To determine the content of trace elements studied 30 women with hair 2nd stage breast cancer who were treated at the Republican Specialized Scientific and Practical Medical Center of Oncology and Radiology, Ministry of Health of the Republic of Uzbekistan in 2016. The study of hair samples for content of trace elements (calcium, potassium, sodium , chlorine, iron, zinc, copper, manganese, cobalt, chromium, selenium, iodine, bromine) was conducted in the laboratory analysis of the activation of the Institute of nuclear physics of Uzbekistan Academy of Sciences (Institute of nuclear physics, Academy of Sciences of Uzbekistan), instrumental neutron activation analysis. 95% confidence interval (CI) of the received data on the micronutrient content of the in hair of patients compared with reference values for the population of Uzbekistan, received at the INP as RUz (Tashkent). Results: showed a reduction of iron, zinc, copper, cobalt and high content of chlorine as compared with the reference values. Conclusions: Studies have shown the possibility of using the results for the primary prevention and identification of risk groups among women, as well as the usefulness of the correction of specialized treatment medication with microelement complexes.

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Section: Introductionunclassified

Analysis of the Content of Microelements in Hair in Patients With Breast Cancer

Yusupbekov¹,

Khudaykulov²,

Danilova³

2019

Problems in oncology

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“…However, they can be responsible for various malfunctions when their homeostasis has been changed. The disorders in the Cu and Zn transport are known to have clinical effects, − and the serum copper level and serum zinc level were reported to correlate with various cancers. − Therefore, the determination of trace elements in the diagnosis of certain diseases can be important.…”

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confidence: 99%

Direct Trace Element Analysis of Liquid Blood Samples by In-Air Ion Beam Analytical Techniques (PIXE–PIGE)

2017

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There are various liquid materials whose elemental composition is of interest in various fields of science and technology. In many cases, sample preparation or the extraction can be complicated, or it would destroy the original environment before the analysis (for example, in the case of biological samples). However, multielement direct analysis of liquid samples can be realized by an external PIXE-PIGE measurement system. Particle-induced X-ray and gamma-ray emission spectroscopy (PIXE, PIGE) techniques were applied in external (in-air) microbeam configuration for the trace and main element determination of liquid samples. The direct analysis of standard solutions of several metal salts and human blood samples (whole blood, blood serum, blood plasma, and formed elements) was realized. From the blood samples, Na, P, S, Cl, K, Ca, Fe, Cu, Zn, and Br elemental concentrations were determined. The focused and scanned ion beam creates an opportunity to analyze very small volume samples (∼10 μL). As the sample matrix consists of light elements, the analysis is possible at ppm level. Using this external beam setup, it was found that it is possible to determine elemental composition of small-volume liquid samples routinely, while the liquid samples do not require any preparation processes, and thus, they can be analyzed directly. In the case of lower concentrations, the method is also suitable for the analysis (down to even ∼1 ppm level) but with less accuracy and longer measurement times.

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