Zinc and Reproduction

Apgar, Jean

doi:10.1146/annurev.nu.05.070185.000355

Cited by 124 publications

(34 citation statements)

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“…There is considerable interest in the role of Zn in reproduction (Apgar, 1985). Since the drastic effects of severe maternal Zn deficiency on the rat fetus were demonstrated (Hurley, 1985), attempts have been made to assess the effect of suboptimal Zn nutriture on fetal development in humans.…”

Section: S U S a N J F A I R W E A T H E R -T A I Tmentioning

confidence: 99%

Zinc in Human Nutrition

Fairweather‐Tait

1988

Nutr. Res. Rev.

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Section: S U S a N J F A I R W E A T H E R -T A I Tmentioning

confidence: 99%

Zinc in Human Nutrition

Fairweather‐Tait

1988

Nutr. Res. Rev.

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“…Thus, when zinc is present in limiting amounts, it can have devastating effects on living organisms. In mammals, zinc deficiency leads to severe dermatitis, growth retardation, mental disorders, and dysfunction of the immune and reproductive systems (4,18,22). High levels of zinc, however, are also deleterious and can lead to cytotoxicity.…”

mentioning

confidence: 99%

Generation and Characterization of Mice Lacking the Zinc Uptake Transporter ZIP3

Dufner-Beattie

Huang

Geiser

et al. 2005

Molecular and Cellular Biology

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The mouse ZIP3 (SLC39A3) gene encodes an eight-transmembrane-domain protein that has been conserved in mammals and can function to transport zinc. To analyze the expression of ZIP3 in the early embryo and neonate and to determine its in vivo function, we generated ZIP3 null mice in which the ZIP3 open reading frame was replaced with that of the enhanced green fluorescent protein (EGFP) reporter. EGFP fluorescence revealed that ZIP3 was expressed in the inner cell mass of the blastocyst and later during embryonic development in many tissues. Elevated expression was apparent in the embryonic brain and neurotube and neonatal gonads. Homozygous knockout mice were viable and fertile and under normal growth conditions exhibited no obvious phenotypic abnormalities. Deletion of ZIP3 did not alter zinc homeostasis at the molecular level as assessed by essential metal levels and the expression of zinc-responsive genes. In knockout mice stressed with a zinc-deficient diet during pregnancy or at weaning, a subtle increase in the sensitivity to abnormal morphogenesis of the embryo and to depletion of thymic pre-T cells, respectively, was noted. These results suggest that this protein plays an ancillary role in zinc homeostasis in mice.

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“…39,40 A de fi ci ency of this es sen ti al me tal re sults in a wi de spec trum of physi o lo gi cal effects, inc lu ding di sor ders of skin as well as ne u ro logi cal, im mu ne, and rep ro duc ti ve systems. 41,42 The se ef fects ref lect the di ver se func ti ons of zinc. It ser ves struc tu ral and/or ca taly tic ro les in hun dreds of pepti des, inc lu ding the re mar kably abun dant su per family of zinc-fin ger pro te ins.…”

Section: Discussionmentioning

confidence: 99%

Catalase and Carbonic Anhydrase Enzyme Activities, and Some Mineral-Heavy Metal Concentrations in Newborns with Congenital Malformations

Melek¹,

Demır²,

Kırımi³

et al. 2011

Turkiye Klinikleri J Med Sci

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A AB BS S T TR RA AC CT T O Ob b j je ec c t ti i v ve e: : The aim of this study is to eva lu a te the fac tors such as an ti o xi dant con di ti on and mine ral-he avy me tal le vel as so ci a ti on that may play a ro le in de ve lop ment of congenital malformations. M Ma a--t te e r ri i a al l a an nd d M Me et t h ho od ds s: : Fif te en he althy ne o na tes as con trol gro up and 15 ne o na tes with va ri o us con ge ni tal malformations we re inc lu ded study. Eryt hrocy te cataly (CAT) which is an an ti o xi dant enz yme, eryt hrocyte carbonic anydrase (CA) enz yme ac ti vi ti es which play a im por tant ro le in acid-ba se ba lan ce, se rum copper (Cu), le ad (Pb), zinc (Zn), cad mi um (Cd), iron (Fe), man ga ne se (Mn) and mag ne si um (Mg) we re me a su red from ve no us blo od samp les of each sub ject. R Re e s su ul lt ts s: : Eryt hrocy te CAT enz yme ac ti vity, se rum Zn and Fe le vels we re sta tis ti cally sig ni fi cantly dec re a sed (P<0.05) in the study gro up whi le se rum Cu and Cd le vels we re sta tis ti cally sig ni fi cantly high (P<0.05)in the study gro up when com pa red to the con trol gro up. A ne ga ti ve cor re la ti on bet we en eryt hrocy te CA ac ti vity and se rum Pb le vels was fo und in the study gro up. In the con trol gro up, ne ga ti ve cor re la ti ons we re fo und bet we en eryt hrocy te CAT ac ti vity and se rum Pb levels; se rum Mg and Cu le vels; and se rum Cd and Mn le vels. In addition, in the con trol gro up a po si ti ve corre la ti on bet we en se rum Zn and Cu le vels; eryt hrocy te CA ac ti vity and se rum Mn le vels was fo und. C Co on nc c l lu u s si i o on n: : Our re sults suggest that eryt hrocy te CAT enz yme ac ti vity and se rum Cu, Zn, Fe and Cd le vels may play a ro le in pat ho ge ne sis of con ge ni tal malformations. The oxi da ti ve stress that ri se as a re sult of an im ba lan ce bet we en pro o xi dant and an ti o xi dant re ac ti ons se ems to be as so ci a ted with con ge ni tal malformations. Furt her stu di es are needed to con firm the as so ci a ti on of an ti o xi dant con di ti on and mi ne ral-he avy me tal le vels in the pat ho ge ne sis of con ge ni tal malformations.K Ke ey y W Wo or rd ds s: : Ca ta la se; car bo nic anhy dra ses; mi ne rals; he avy me tals; con ge ni tal, he re di tary, and ne o na tal di se a ses and ab nor ma li ti es Ö ÖZ ZE ET T A Am ma aç ç: : Bu ça lış ma da kon je ni tal ano ma li le rin pa to ge ne zi ni ay dın lat ma ya yö ne lik ola rak; ano ma li geli şi min de rol ala bi le cek fak tör ler den an ti ok si dan du rum ve mi ne ral-ağır me tal se vi ye si iliş ki si nin de ğer lendi ril me si amaç lan dı. G Ge e r re eç ç v ve e Y Yö ön n t te em m l le er r: : Ça lış ma ya çe şit li kon je ni tal ano ma li le ri olan 15 ye ni do ğan ve kon trol gru bu ola rak 15 sağ lık lı ye ni do ğan da hil edil di. Her bir ol gu nun alı nan ve nöz kan ör nek le rin den bir an ti-ok si dan en zim olan erit ro sit katalaz (CAT) ve asit-baz den ge sin de önem li bir rol oy na yan erit ro sit karbonik anhidraz (CA) e...

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Zinc and Reproduction

Cited by 124 publications

References 0 publications

Zinc in Human Nutrition

Zinc in Human Nutrition

Generation and Characterization of Mice Lacking the Zinc Uptake Transporter ZIP3

Catalase and Carbonic Anhydrase Enzyme Activities, and Some Mineral-Heavy Metal Concentrations in Newborns with Congenital Malformations

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