Zinc and Selenium Status in Pediatric Malignant Lymphomas

Çavdar, Ayhan O.; Gözdaşoĝlu, Sevgi; Babacan, Emel; Mengübaş, K; Ünal, Emel; Yavuz, Gülsan; Taçyıldız, Nurdan

doi:10.1080/01635580903285189

Cited by 14 publications

(12 citation statements)

References 18 publications

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“…No significant differences among single diagnoses were found both for Zn 2+ and MT. It is obvious that Zn 2+ content in patients with solid childhood tumours is decreased , which is in well agreement with the previously published studies, where zinc status has been studied in Hodgkin's lymphoma, leukaemia, bone and brain tumours . When determined Zn 2+ /MT ratio, its value was 24.6 in controls, but the ratio was 2.6 in patients.…”

Section: Resultssupporting

confidence: 91%

Use of brightness wavelet transformation for automated analysis of serum metallothioneins‐ and zinc‐containing proteins by Western blots to subclassify childhood solid tumours

et al. 2013

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In this study, we determined serum levels of metallothioneins (MTs) and zinc in children with solid tumours (neuroblastoma, Hodgkin lymphoma, medulloblastoma, osteosarcoma, Ewing sarcoma and nephroblastoma) by differential pulse voltammetry Brdicka reaction and ELISA. Zn(II) level in patients sera was 40% compared to controls, contrariwise, MT level was 4.2 × higher in patients. No significant differences among single diagnoses were found both for Zn(II) and MT. When determined Zn(II)/MT ratio, in controls its value was 24.6, but it was 2.6 in patients. After Western-blotting with anti-MT and anti-Zn chicken antibodies, variable intensities of the bands within the samples were observed. The brightness curve obtained for each sample both for MT- and Zn blots was further analysed to produce a list of band positions together with some complementary information related to the intensity of the observed bands by the optimised algorithm. We constructed from those profiles decision trees that enable to distinguish different groups of tumours. The blood samples were heat-treated, in which we supposed mainly MT, but samples contained other thermostable Zn-containing proteins that were helpful for identification of embryonal tumours with 88% accuracy and for identification of sarcomas with 78% accuracy. In MT blots the accuracies were 53 and 45%, respectively. Simultaneous analysis of MT and Zn blots did not increased accuracy of identification neither in embryonal tumours (80%) nor in sarcomas. Those results are promising not only from diagnostic point of view but particularly in the area of studying of individual MT isoforms and their aggregates in malignant tumours.

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Section: Resultssupporting

confidence: 91%

Use of brightness wavelet transformation for automated analysis of serum metallothioneins‐ and zinc‐containing proteins by Western blots to subclassify childhood solid tumours

et al. 2013

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“…The incidence of poor zinc and selenium status is high in certain territories (Diplock, 1993;Prasad, 2003). It is notable that combined zinc and selenium defi ciency is frequently observed in a number of pathologic states (Barretto et al, 2008;Çavdar et al, 2009;Khalili et al, 2008) as well as in relatively healthy population (De Jong et al, 2001). Such a fact indicates a signifi cant association between Zn and Se homeostasis.…”

Section: Introductionmentioning

confidence: 99%

Effect of short-term zinc supplementation on zinc and selenium tissue distribution and serum antioxidant enzymes

Skalny

Tinkov

Medvedeva

et al. 2015

Acta Sci Pol Technol Aliment

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Background.A signifi cant association between Zn and Se homeostasis exists. At the same time, data on the infl uence of zinc supplementation on selenium distribution in organs and tissues seem to be absent. Therefore, the primary objective of the current study is to investigate the infl uence of zinc asparaginate supplementation on zinc and selenium distribution and serum superoxide dismutase (SOD) and glutathione peroxidase (GPx) activity in Wistar rats. Material and methods. 36 rats were used in the experiment. The duration of the experiment was 7 and 14 days in the fi rst and second series, respectively. The rats in Group I were used as the control ones. Animals in Groups II and III daily obtained zinc asparaginate (ZnA) in the doses of 5 and 15 mg/kg weight, respectively. Zinc and selenium content in liver, kidneys, heart, muscle, serum and hair was assessed using inductively coupled plasma mass spectrometry. Serum SOD and GPx activity was analysed spectrophotometrically using Randox kits. Results. Intragastric administration of zinc asparaginate signifi cantly increased liver, kidney, and serum zinc content without affecting skeletal and cardiac muscle levels. Zinc supplementation also stimulated selenium retention in the rats' organs. Moreover, a signifi cant positive correlation between zinc and selenium content was observed. Finally, zinc asparaginate treatment has been shown to modulate serum GPx but not SOD activity. Conclusion. The obtained data indicate that zinc-induced increase in GPx activity may be mediated through modulation of selenium status. However, future studies are required to estimate the exact mechanisms of zinc and selenium interplay.

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“…It also increases circulation of T-lymphocytes in the blood and also enhances the ability to fight infection. Multiple studies have revealed that Zn deficiency causes T-cell dysfunction, impair cellular immune functions, dysfunction of neutrophils and natural killer cells 13 . Alternatively, Zn deficiency and its associated immune suppression may represent a paraneoplastic syndrome secondary to certain types of cancer 31 .…”

Section: Resultsmentioning

confidence: 99%

Disparities in the Concentrations of Essential/Toxic Elements in the Blood and Scalp Hair of Lymphoma Patients and Healthy Subjects

Qayyum

Shah

2019

Sci Rep

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Lymphoma is one of the fastest growing malignancies worldwide and imbalance in the concentrations of trace elements can play a significant role in the onset and progression of the disease. Selected essential and toxic elements (Fe, Zn, Cu, Mn, Ni, Cr, Cd and Pb) were analysed in the blood & scalp hair of lymphoma patients (n = 59 & 58, respectively) and controls (n = 61 & 60, respectively) by atomic absorption spectrometry. On the average, Ni, Cr, Cu and Cd revealed significantly higher contents in the blood and scalp hair of the patients than the controls (p < 0.05). The correlation study showed significantly diverse relationships among the elements in blood & scalp hair of the two donor groups. Variations in the elemental levels with different types of lymphoma (non-Hodgkin and Hodgkin) were also evaluated. Disparities in the elemental concentrations were also investigated for various types of non-Hodgkin (diffuse large B-cell lymphoma, follicular lymphoma and peripheral T-cell lymphoma) and Hodgkin lymphoma (mixed cellularity, nodular lymphocyte predominant and nodular sclerosing), as well as for different stages (I, II, III & IV) of the cancer. Multivariate statistical analysis showed considerably divergent associations of the elements in the patients and controls. The study indicated profound alteration of the elemental levels in the patients; it may be implicated in elemental-induced disorders including lymphoma.

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Zinc and Selenium Status in Pediatric Malignant Lymphomas

Cited by 14 publications

References 18 publications

Use of brightness wavelet transformation for automated analysis of serum metallothioneins‐ and zinc‐containing proteins by Western blots to subclassify childhood solid tumours

Use of brightness wavelet transformation for automated analysis of serum metallothioneins‐ and zinc‐containing proteins by Western blots to subclassify childhood solid tumours

Effect of short-term zinc supplementation on zinc and selenium tissue distribution and serum antioxidant enzymes

Disparities in the Concentrations of Essential/Toxic Elements in the Blood and Scalp Hair of Lymphoma Patients and Healthy Subjects

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