Zinc Deficiency and Long-Term Outcome in Cases After Isolated Intestinal Transplantation in Taiwan

Chen, Y.; Tseng, Sheng-Hong; Koh, Chee-Chee; Chung, Chen‐Shuan; Weng, Chia-Chee; Tsai, Yu-Chen

doi:10.1016/j.transproceed.2018.03.094

Cited by 3 publications

(1 citation statement)

References 7 publications

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“…From 2007 to 2022, we conducted 31 ITx surgeries for 30 patients, with 5 year survival rates of 71.0% for patients and 51.6% for grafts, comparable to global figures [4,5,24]. To improve long-term outcomes by reducing graft loss related to acute rejection, we aimed to explore non-invasive biomarkers to enhance the accuracy and timeliness of acute rejection diagnosis.…”

Section: Introductionmentioning

confidence: 99%

Application of Intestinal Barrier Molecules in the Diagnosis of Acute Cellular Rejection After Intestinal Transplantation

Chen,

Tseng,

Chen

et al. 2023

Transpl Int

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Diagnosing acute rejection after intestinal transplantation currently heavily relies on histopathological analysis of graft biopsies. However, the invasive risks associated with ileoscopic examination and the inaccessibility for biopsy after ileostomy closure hinder real-time detection of rejection responses. Molecules comprising the intestinal barrier have been identified as physiological and molecular biomarkers for various bowel conditions and systemic diseases. To investigate the potential of barrier function-related molecules in diagnosing rejection after intestinal transplantation, plasma samples were collected longitudinally from transplant recipients. The samples were categorized into “indeterminate for rejection (IND)” and “acute rejection (AR)” groups based on clinical diagnoses at each time point. The longitudinal association between plasma levels of these barrier function-related molecules and acute rejection was analyzed using the generalized estimating equations (GEE) method. Logistic GEE models revealed that plasma levels of claudin-3, occludin, sIgA, and zonulin were independent variables correlated with the clinical diagnosis of acute rejection. The subsequent prediction model demonstrated moderate ability in discriminating between IND and AR samples, with a sensitivity of 76.0%, specificity of 89.2%, and accuracy of 84.6%. In conclusion, monitoring plasma levels of claudin-3, occludin, sIgA, and zonulin shows great potential in aiding the diagnosis of acute rejection after intestinal transplantation.

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Section: Introductionmentioning

confidence: 99%

Application of Intestinal Barrier Molecules in the Diagnosis of Acute Cellular Rejection After Intestinal Transplantation

Chen,

Tseng,

Chen

et al. 2023

Transpl Int

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Efficacy of same venous route Hickman catheter replacement in patients with intestinal failure

Koh

Tsai

et al. 2023

Journal of the Formosan Medical Association

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Current status of intestinal transplantation in East Asia

Hibi

Chen

Kim

et al. 2020

Current Opinion in Organ Transplantation

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Purpose of review Intestinal transplantation (ITx) activity remains low in East Asia. We conducted a multinational, retrospective study on patients who underwent ITx in Korea, Taiwan, and Japan, to provide an overview and to foresee future developments and collaborations in this region. Recent findings Total 71 ITx were performed in 67 patients. Living donor ITx was most commonly conducted in Japan (n = 13). Despite the low caseload, all three countries demonstrated acceptable patient survival rates of approximately 70% at 5 years. Over 70% of recipients with a functioning graft were free from total parenteral nutrition. Summary There is an urgent need to establish a nationwide and multinational registry of ITx recipients and patients with intestinal failure in East Asia. An efficient referral system to specialized intestinal rehabilitation and ITx centers and a multidisciplinary team approach is also warranted to provide state-of-the-art treatment for patients desperately waiting for a chance to survive.

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Zinc Deficiency and Long-Term Outcome in Cases After Isolated Intestinal Transplantation in Taiwan

Cited by 3 publications

References 7 publications

Application of Intestinal Barrier Molecules in the Diagnosis of Acute Cellular Rejection After Intestinal Transplantation

Application of Intestinal Barrier Molecules in the Diagnosis of Acute Cellular Rejection After Intestinal Transplantation

Efficacy of same venous route Hickman catheter replacement in patients with intestinal failure

Current status of intestinal transplantation in East Asia

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