2022
DOI: 10.3389/fmicb.2022.975632
|View full text |Cite
|
Sign up to set email alerts
|

Zinc-finger antiviral protein-mediated inhibition of porcine epidemic diarrhea virus growth is antagonized by the coronaviral nucleocapsid protein

Abstract: Coronaviruses have long posed a major threat not only to human health but also to agriculture. Outbreaks of an animal coronavirus such as porcine epidemic diarrhea virus (PEDV) can cause up-to-100% mortality in suckling piglets, resulting in devastating effects on the livestock industry. Understanding how the virus evades its host’s defense can help us better manage the infection. Zinc-finger antiviral protein (ZAP) is an important class of host antiviral factors against a variety of viruses, including the hum… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1

Citation Types

0
0
0

Year Published

2024
2024
2025
2025

Publication Types

Select...
4

Relationship

0
4

Authors

Journals

citations
Cited by 4 publications
(3 citation statements)
references
References 40 publications
0
0
0
Order By: Relevance
“…In one study, recombinant PEDV with a recoded N gene was generated [132]. An increase in the CpG content in the N gene renders the recoded virus more susceptible to ZAP and grows poorly in Vero cells [132]. Although this study did not continue with the animal immunization experiment to verify the virulence and immunogenicity of the recoded PEDV, the results emanated the potential of the SAVE technique in designing and developing PED LAV candidates.…”
Section: Constructing Ped Lav Candidates With Other Genetic Modificat...mentioning
confidence: 95%
See 2 more Smart Citations
“…In one study, recombinant PEDV with a recoded N gene was generated [132]. An increase in the CpG content in the N gene renders the recoded virus more susceptible to ZAP and grows poorly in Vero cells [132]. Although this study did not continue with the animal immunization experiment to verify the virulence and immunogenicity of the recoded PEDV, the results emanated the potential of the SAVE technique in designing and developing PED LAV candidates.…”
Section: Constructing Ped Lav Candidates With Other Genetic Modificat...mentioning
confidence: 95%
“…As a viral suppressor of RNA silencing, the PEDV N protein suppresses short hairpin RNA-induced RNA interference of the host cell to promote viral replication, potentially affecting viral pathogenesis [131]. Research has also shown that the PEDV N protein can interact with the zinc-finger antiviral protein (ZAP) in host cells to antagonize its antiviral activity [132]. Mechanistically, the PEDV N protein suppresses the activation of ZAP by its essential cofactor, tripartite motif-containing protein 25 (TRIM25), in which the N protein interacts with both ZAP and TRIM25 through its N-terminal domain and C-terminal domain, respectively [133].…”
Section: N Proteinmentioning
confidence: 99%
See 1 more Smart Citation