Zinc Finger E-Box Binding Homeobox 2 as a Prognostic Biomarker in Various Cancers and Its Correlation with Infiltrating Immune Cells in Ovarian Cancer

Abstract

This study investigated the expression of zinc finger E-box binding homeobox 2 (ZEB2), its prognostic significance in various cancers, and the correlation between ZEB2 and infiltrating immune cells and ZEB2-related proteins in ovarian cancer (OV). The Gene Expression Profiling Interactive Analysis tool was used to analyze RNA sequencing data and cancer survival rates, based on normal and tumor tissue data available in The Cancer Genome Atlas (TCGA) database. The Kaplan–Meier plotter and PrognoScan databases were used to analyze the prognostic value of ZEB2 in OV (n = 1144). The Tumor Immune Estimation Resource was used to investigate the correlation between ZEB2 and infiltrating immune cells in various cancers, including OV. High ZEB2 expression was associated with a poorer prognosis in OV. In OV, ZEB2 is positively correlated with CD8+T cells, neutrophils, macrophages, and dendritic cell invasion; and ZEB2 is negatively correlated with tumor-infiltrating B cells. The STRING database was used to investigate the correlations with ZEB2-related proteins. The results reveal that ZEB2 was positively correlated with SMAD1 and SMAD2 in OV. Our findings may serve as a potential prognostic biomarker, and provide novel insights into the tumor immunology in OV. Thus, ZEB2 may be a potential diagnostic and therapeutic target in OV.

Role of SH3PXD2B in Breast Cancer Lung Metastasis through Computational Structural and Systems Perspective

“…Based on scientific literature the proteins involved in breast cancer metastasis to lung and published data for their associated transcription factors available in multiple databases was collected to construct an integrated bio-molecular interaction network of Transcription Factor-Target Gene (TFTG). In our study, we used an enlisted 22 metastatic proteins reported through various literatures playing a crucial role in breast cancer lung metastasis [116][117][118][119][120][121][122][123][124][125][126]. The associated transcription factors regulating the expression of these metastatic proteins were fished from the TF2DNA and TF link databases, which offer detailed and extremely reliable information on transcription factor -target gene interactions for numerous organisms, including Homo sapiens.…”

Molecules at Play in Cancer

“…The 24 chapters present the contributions of 166 researchers from 16 countries: Brazil (14), China (12), Ecuador (2), Greece (10), Hungary (8), Italy (4), Japan (25), Korea (29), Mexico (11), Poland (5), Portugal (2), Russia (2), Switzerland (7), the UK (1) and the USA (27). The articles reported new molecular findings regarding the following types of cancer: blood [ 1 , 2 ], breast [ 3 , 4 , 5 ], kidney [ 6 ], liver [ 7 , 8 ], lung [ 9 , 10 , 11 , 12 ], ovary [ 10 , 13 , 14 ], prostate [ 15 ], soft tissue [ 16 ], gastric [ 17 , 18 ], testicular [ 19 ], cervical [ 20 , 21 ], and adrenal gland [ 22 ].…”

“…For several studies, genomic data were downloaded from The Cancer Genome Atlas (TCGA). Liu et al [ 17 ] used these data to determine the prognostic value of miR-942-3p for the gastric cancer, Ferreira et al [ 6 ] to determine the value of GOT2 in clear–cell renal-cell carcinoma, and Kim et al [ 13 ] to determine that of zinc finger E-box binding homeobox 2 in ovarian cancer.…”