Zinc in plasma and platelets in patients on regular haemodialysis

Plasma and intracellular (platelet) zinc levels in chronic renal failure (CRF) patients under different treatment modalities

“…Platelet Zn was significantly decreased after the dialysis session compared to their values before dialysis in the two dialytic subgroups in our study. Similar results were obtained by Iotova et al [6] and this transient change may be attributed to changes that occur during dialysis as redistribution of Zn from platelet to plasma or to the increased platelet count as we found III our patients during hemodialysis secondary to the effect of anticoagulants. We also found that there was no significant difference between the change in Zn status (plasma & platelet) in patients under HD in comparison to those under peritonial dialysis, indicating no superiority of either type of dialysis for correction of Zn status in CRF.…”

“…Hinks After a single dialysis session we found that plasma Zn was significantly higher in both dialytic subgroups compared to their values before the session, however, levels were still significantly lower than controls. This elevation was in agreement with the result obtained It may be due to haemoconcentration as packed cell volume (PCV) was also significantly higher after the dialysis session although it was still lower than that of controls [6]. Platelet Zn was significantly decreased after the dialysis session compared to their values before dialysis in the two dialytic subgroups in our study.…”

“…Meanwhile plasma but not platelet Zn was transiently and significantly increased in patients on bicarbonate haemodialysis compared to those using acetate buffer. This finding was confirmed by Iotova et al [6], denoting a more beneficial effect of bicarbonate buffer for correction of acidosis with subsequent improvement of Zn absorption. We can conclude that intracellular measurrnent of Zn (platelet)…”

“…Zn is an essential component of a large number of metalloenzymes and is important for normal metabolism in man [6]. It had been reported that patients with chronic renal failure have an abnormal zinc metabolism [16].…”

Possible Site of Decreased Intestinal Zinc Absorption in Chronic Uremic Rats

“…The zinc metabolism is altered in chronic uremia, and it is not corrected by maintenance dialysis therapy [3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16]. Zinc supplementation has been shown to improve some abnormalities in uremic patients [8, 9, 10, 17].…”