Zinc may be a mediator of leptin production in humans

Chen, Ming-Der; Song, Yuh-Min; Lin, Pi-Yao

doi:10.1016/s0024-3205(00)00541-5

Cited by 86 publications

(68 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In the study of Chen et al, 18 high leptin levels and low zinc levels in the experimental group were detected compared with the control group, demonstrating the existence of an inverse correlation between these variables.…”

Section: Resultsmentioning

confidence: 85%

“…13 Moreover, several factors exert a direct influence on leptin levels, such as glucocorticoids, physical exercise 14,15 and zinc. [16][17][18] Cortisol is a glucocorticoid secreted by the adrenal cortex and among other functions, increases glyconeogenesis and promotes fat mobilization and utilization. 19,20 Zinc also plays an important role in appetite regulation and may thus be expected to act as a mediator of leptin effects.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The response of serum leptin, cortisol and zinc concentrations to concurrent training

Rosa¹,

Dantas²,

Mello³

2011

View full text Add to dashboard Cite

ObjectIve: to investigate the effects of concurrent training (ct) on serum leptin, cortisol and zinc concentrations in physically active adults. DesIGN: ten subjects aged (27.1±4.8 years, bMI 25.49 ± 2.65) were recruited to participate in three sessions: control session (cs), concurrent training 1 (ct1) and concurrent training 2 (ct2) sessions with five days of resting between them. In each session blood samples for leptin, cortisol and zinc determination were collected. ct1 session included indoor cycling class followed by strength training. ct2 session included strength training, followed by indoor cycling class. In cs there were no exercises. the shapiro-Wilk test, repeated ANOvA test and tukey Post-Hoc test were used. resULts: there was a reduction in leptin levels after CT1 (Δ% = -16.04; p = 0.05) and CT2 (Δ% = -8.54; p = 0.02). Cortisol also showed a reduction after CT1 (Δ% = -26.32; p = 0.02) and CT2 (Δ% = -33.57; p = 0.05), whereas zinc did not show any significant alterations after any of the training sessions. there was also significant difference for the leptin and cortisol values between ct1 and ct2. cONcLUsIONs: ct promoted reduction in serum leptin and cortisol levels independently of the training order, while no significant changes in zinc concentrations were observed.

show abstract

Section: Resultsmentioning

confidence: 85%

Section: Introductionmentioning

confidence: 99%

The response of serum leptin, cortisol and zinc concentrations to concurrent training

Rosa¹,

Dantas²,

Mello³

2011

View full text Add to dashboard Cite

show abstract

“…Neste estudo, não foi encontrada associação entre as concentrações séricas de zinco e leptina, PCR-US, ácido úrico e homocisteína. A leptina é uma adipocina que está relacionada ao mecanismo de saciedade, e alguns trabalhos encontraram correlação inversa com a concentração sérica de zinco em adultos e crianças 12,33 , devido ao papel do zinco como um mediador na produção de leptina no tecido adiposo subcutâneo 33 e ao efeito da ZAG nas concentrações de leptina. Sua baixa expressão em indivíduos obesos está associada à diminuição sérica de leptina, podendo desempenhar um papel importante na patogênese da obesidade 33 .…”

Section: Discussionunclassified

“…A leptina é uma adipocina que está relacionada ao mecanismo de saciedade, e alguns trabalhos encontraram correlação inversa com a concentração sérica de zinco em adultos e crianças 12,33 , devido ao papel do zinco como um mediador na produção de leptina no tecido adiposo subcutâneo 33 e ao efeito da ZAG nas concentrações de leptina. Sua baixa expressão em indivíduos obesos está associada à diminuição sérica de leptina, podendo desempenhar um papel importante na patogênese da obesidade 33 . A ação anti-inflamatória do zinco pode ser um dos fatores que contribuem para a inibição da produção de citocinas pró-inflamatórias e diminuição da PCR 14 .…”

Section: Discussionunclassified

Associação das concentrações séricas de zinco com hipercolesterolemia e resistência à insulina em crianças brasileiras

et al. 2018

View full text Add to dashboard Cite

Associação das concentrações séricas de zinco com hipercolesterolemia e resistência à insulina em crianças brasileirasAssociation between serum zinc level and hypercholesterolemia and insulin resistance in Brazilian children Asociación de las concentraciones séricas de zinc con la hipercolesterolemia y resistencia a la insulina en niños brasileñas (RP = 1,96; IC95%: 1,66) e a de hipercolesterolemia foi 23% menor (RP = 0,77; IC95%: 0,96)

show abstract

“…in particular, leptin expression is increased in the presence of zinc, while leptin expression and secretion decreases in response to zinc depletion in adipocytes (27)(28)(29). apart from participating in the regulation of leptin secretion, zinc A B C D also seems to be intimately involved in the modulation of adipose tissue release of free fatty acids and glucose uptake in adipocytes, where zinc per se functions as an insulinomimetic (30).…”

Section: Discussionmentioning

confidence: 99%

Down-regulation of zinc transporter 8 in the pancreas of db/db mice is rescued by Exendin-4 administration

Liu

Jiang

et al. 2010

Mol Med Rep

View full text Add to dashboard Cite

Abstract. recent human genetic studies have revealed that common variants of the zinc transporter 8 (ZnT-8) gene are strongly associated with type 2 diabetes mellitus (T2dM). ZnT-8 has been suggested as a potential candidate in the regulation of insulin secretion in pancreatic β-cells. in this study, we aimed to explore the expression of ZnT-8 in the development of T2dM. The expression of ZnT-8 was investigated in the pancreas and adipose tissue of homozygous db/ db mice compared to heterozygous sibling db/+ mice (n=6-8). Furthermore, the effect of exendin-4 (an analogue of glucagon-like peptide-1) on ZnT-8 expression was examined in the db/db mice. exendin-4 or vehicle (control) was administered (i.p., 1 nmol/kg) to diabetic 8-week-old db/db mice daily for 14 days (n=8). The results revealed that ZnT-8 protein levels in the pancreas of db/db mice were reduced, accompanied by a decrease in ZnT-8 mrna. ZnT-8 mrna and protein levels were also significantly reduced in the epididymal and visceral fat of the db/db mice. Treatment with exendin-4 up-regulated ZnT-8 gene expression in the pancreas of the db/db mice, but did not affect its expression in adipose tissue. These findings suggest that ZnT-8 synthesis in the pancreas and adipose tissue is down-regulated in db/db mice. reduced ZnT-8 production in the pancreas may advance defects in insulin secretion in diabetes. These may be reversed, at least partially, by the administration of exendin-4.

show abstract

Zinc may be a mediator of leptin production in humans

Cited by 86 publications

References 22 publications

The response of serum leptin, cortisol and zinc concentrations to concurrent training

The response of serum leptin, cortisol and zinc concentrations to concurrent training

Associação das concentrações séricas de zinco com hipercolesterolemia e resistência à insulina em crianças brasileiras

Down-regulation of zinc transporter 8 in the pancreas of db/db mice is rescued by Exendin-4 administration

Contact Info

Product

Resources

About