Zinc oxide nanoparticles enhance expression of maspin in human breast cancer cells

SnO2-Doped ZnO/Reduced Graphene Oxide Nanocomposites: Synthesis, Characterization, and Improved Anticancer Activity via Oxidative Stress Pathway

“…Cytotoxic potential of ZnO NPs against different types of cancer cell lines has also been reported by other investigators. [46][47][48] For example, a recent study reported anticancer activity of ZnO NPs against human small-cell lung cancer in an orthotopic mouse model. 10 Apoptosis Apoptosis (a form of programmed cell death) might be stimulated by various internal or external factors such as injury, stress, starvation, and known apoptotic agents.…”

Subcellular Expression of Maspin in Colorectal Cancer: Friend or Foe

“…In tumors such breast cancer maspin level was described to be dependent on the estrogen receptors α and β [7,17]. In line with these data, tamoxifen, which is used as a variant of hormonal therapy, proved to stimulate the secretion of maspin in the myoepithelial cells, without significant changes at mRNA level [7].…”

“…Maspin can be down-or upregulated in tumors but the significance of these changes, correlated with maspin subcellular localization, compared with parental tissues, is far to be understood. Most of the published papers refers to maspin expression in carcinomas [4,6,16,17]. In the previously published reports, maspin was examined in particular in breast carcinomas and CRCs, but it was reported to also mark carcinomas of the oral cavity, esophagus, stomach, larynx, lung, pancreas, thyroid, prostate, ovary and urinary bladder [5,6,[17][18][19].…”

“…Most of the published papers refers to maspin expression in carcinomas [4,6,16,17]. In the previously published reports, maspin was examined in particular in breast carcinomas and CRCs, but it was reported to also mark carcinomas of the oral cavity, esophagus, stomach, larynx, lung, pancreas, thyroid, prostate, ovary and urinary bladder [5,6,[17][18][19].…”

Emerging Role of Redox-Active Nanoceria in Cancer Therapeutics via Oxidative Stress

“…Nanoparticles (NPs) possess special properties like small particle size, variable particle shape, high surface area to volume ratio, high cell penetration ability, and various other superior electronic, mechanical, optical, and magnetic properties as compared to their bulk materials (Singh et al 2020;Thakur et al 2020). Due to these advantageous properties, NPs show profound applications in the field of biomedicine (Sharma and Das 2019;Singh et al 2020;Tejwan et al 2020;Thakur et al 2019) especially to treat different types of cancers (Aplak et al 2020;Boobalan et al 2020;Gomathi et al 2020;Gowdhami et al 2019;Khorsandi and Farasat 2020;Munawer et al 2020). Among various NPs, CeO 2 NPs or nanoceria has emerged as a potential nanomaterial and attained much attention of nano-biotechnologists due to its unique chemical, physical, and surface properties (Kuddus 2017).…”