Zinc oxide nanoparticles inhibit Ca2+-ATPase expression in human lens epithelial cells under UVB irradiation

Wang, Dingsheng; Guo, Dadong; Wu, Qiuxin; Tian, Qingmei; Du, Yi

doi:10.1016/j.tiv.2013.09.015

Cited by 35 publications

(16 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…They concluded that the disrupted calcium homeostasis would trigger mitochondrial dysfunction, generate excessive ROS, and finally initiate cell death. Wang et al (2013) showed that Zn NPs inhibited Ca-ATPase expression in human lens epithelial cells under ultraviolet irradiation. Kumari et al (2013) studied the acute oral effects of high doses of Fe NPs in rats.…”

Section: Osmoregulation System Enzymesmentioning

confidence: 99%

Effects of aluminum, copper, and titanium nanoparticles onsome blood parameters in Wistar rats

Canli¹,

Canli²

2017

Turk J Zool

View full text Add to dashboard Cite

IntroductionFollowing recent technological developments, nanosized (<100 nm) metal complexes have entered into different areas of human lives and the discussion of their potential effects on humans and the environment has begun (Jeng and Swanson, 2006;Janrao et al., 2014). The areas in which nanoparticles (NPs) are used for anthropogenic purposes include medicine, the textile and electronic industries, filters, toothpaste, suntan cream, toys, moisturizers, packing products, household appliances, and the food industry. Although they are widely used, there are no satisfactory data on the environmental fate of these particles, despite vigorous attempts to find out their possible effects in different groups of animals. Those studies indicated that NPs may possess health hazard effects, domestically, medically, and environmentally, due to their high surfaceto-volume ratio, small size, crystallinity, electronic properties, surface structure, reactivity, functional groups, inorganic or organic coatings, shape, and aggregation behavior, which can make the particles very reactive or catalytic (Keller et al., 2010;Schrand et al., 2010;Janrao et al., 2014). NPs are able to pass through cell membranes and their interactions with biological systems are relatively unknown (Ahamed et al., 2010; Jeng and Swanson, 2014). Therefore, NPs can potentially cause adverse effects on organs, tissues, cellular and subcellular functions, and enzymes due to their unusual physicochemical properties (Keller et al., 2010;Schrand et al., 2010). Studies have shown that NPs have toxic effects on mammals depending on metal type, size, dose, and administration route of these particles (Elle et al., 2013;Wang et al., 2013; Jeng and Swanson, 2014). Although the literature data present so far are not consistent and do not show clear evidence of the toxicity of NPs, it seems they are not innocent products of mammalian metabolism. Biomarkers belonging to different metabolic systems in mammals were altered by NPs administrated via the oral route, inhalation, or subcutaneous injection (

show abstract

Section: Osmoregulation System Enzymesmentioning

confidence: 99%

Effects of aluminum, copper, and titanium nanoparticles onsome blood parameters in Wistar rats

Canli¹,

Canli²

2017

Turk J Zool

View full text Add to dashboard Cite

show abstract

“…However, if the SCW process is an interesting way to produce various nanopowders, the nucleation/growth mechanisms are still unknown [3]. Consequently, in order to improve the knowledge of these mechanisms in supercritical water domain, it was useful to select an uncomplicated reference material such as ZnO which is largely studied in SCW hydrothermal synthesis and also well documented in the literature [4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22]. Indeed, ZnO material crystallizes in a single stable wurtzite phase without secondary phases such as hydroxide in SCW domain compared to other metal oxides (TiO 2 , Cu x O, Ce x O y .…”

Section: Introductionmentioning

confidence: 99%

“….). Moreover, ZnO NPs find various applications in different fields such as optoelectronic transducers, chemical and gas sensors, photocatalyst, etc., because of a very wide range of morphologies as wires, flowers, rods, tubes, sheets, ribbons, plates, dumbbell, disks and springs [4][5][6][7][8][9][10][11][12][13][14]. The crystallite characteristics of ZnO NPs in terms of size and morphology can be tuned with experimental conditions such as the temperature [15][16][17][18], the nature and the concentration of the metallic precursor and the alkali solution [15,16,[19][20][21].…”

Section: Introductionmentioning

confidence: 99%

“…About the effect of the metal precursor concentration, Ohara et al [21] showed that the ZnO rods are smaller when Zn(II) concentration is increased without an addition of alkali solutions whereas other studies performed in alkali medium showed that spherical ZnO NPs are produced with reduced size when the Zn(II) concentration decreases [15,16,19,20]. However, it is very difficult to compare the size and the morphology of ZnO particles obtained from these studies [4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22] because of differences in residence time, ranges of pressure and temperature, type of reactor (batch or continuous process) and reactants, especially the counter-ion nature of the alkali solution (Na + , K + , Li + ) and the metallic precursor (nitrate, acetate and sulfate).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Hydrothermal growth of ZnO nanostructures in supercritical domain: Effect of the metal salt concentration (Zn(NO3)2) in alkali medium (KOH)

Demoisson

Piolet

Bernard

2015

The Journal of Supercritical Fluids

View full text Add to dashboard Cite

“…boron nitride) [245], and oxides (e.g. zinc, titanium, iron oxide, manganese) [246][247][248][249][250]. Currently, hollow mesoporous nanospheres are of particular interest due to their high drug loading efficiency and minimal toxicity in vivo.…”

Section: Organic Nanoparticles For Lung Cancermentioning

confidence: 99%

Study of novel nanoparticle transport and drug release for cancer treatment.

Gene¹

View full text Add to dashboard Cite

Nano-scale particles sized 10-400 nm administered systemically preferentially extravasate from tumor vasculature due to the enhanced permeability and retention effect. Therapeutic success remains elusive, however, because of inhomogeneous particle distribution within tumor tissue. Insufficient tumor vascularization limits particle transport and also results in avascular hypoxic regions with non-proliferating cells, which can regenerate tissue after nanoparticle-delivered cytotoxicity or thermal ablation. In this study, gold nanoparticles were functionalized with phosphatidylcholine (two-layer) or phosphatidylcholine and HDL (three-layer) in the formation of "layered" nanoparticles. The diffusivity of both two-and three layered colloidal gold nanoparticles and silica gold nanoshells were examined in 3D cell cultures. Both two-and three layered nanoparticles showed enhanced diffusivity in comparison to previously developed PEGylated nanoparticles. As the two layer nanoparticles displayed enhanced diffusivity in comparison to three layer nanoparticles, the two layered nanoparticles were further examined in vivo using mice implanted with orthotopic pancreatic adenocarcinomas. The two layer colloidal gold nanoparticles showed enhanced diffusivity in comparison to silica gold nanoshells in vivo, suggesting that smaller nanoparticles were able to localize and diffuse from vasculature better than larger nanoparticles. Overall accumulation of solid gold nanoparticle accumulated in the tumor and filtering organs (liver and spleen) was 2X higher than silica gold nanoshells. Thus, two layer colloidal gold nanoparticles were loaded with cisplatin or paclitaxel to determine optimal drug release kinetics. Drug release from paclitaxel-loaded nanoparticles displayed a slower release while cisplatin-loaded nanoparticles experienced an initial burst of drug release followed by a slower release of remaining drug. Lastly, drug-loaded colloidal gold nanoparticles were tested in 3D cell cultures to determine their cytotoxicity. Both two and three layer nanoparticles loaded with cisplatin or v paclitaxel showed similar efficacy to drug alone, suggesting their viable use in vivo for cancer treatment.This study has demonstrated the potential use of layered nanoparticles for increasing the delivery of chemotherapeutics deeper into tumor tissue.

show abstract

Zinc oxide nanoparticles inhibit Ca2+-ATPase expression in human lens epithelial cells under UVB irradiation

Cited by 35 publications

References 39 publications

Effects of aluminum, copper, and titanium nanoparticles onsome blood parameters in Wistar rats

Effects of aluminum, copper, and titanium nanoparticles onsome blood parameters in Wistar rats

Hydrothermal growth of ZnO nanostructures in supercritical domain: Effect of the metal salt concentration (Zn(NO3)2) in alkali medium (KOH)

Study of novel nanoparticle transport and drug release for cancer treatment.

Contact Info

Product

Resources

About