Zinc oxide particles induce inflammatory responses in vascular endothelial cells via NF-κB signaling

Tsou, Tsui‐Chun; Yeh, Szu-Ching; Tsai, Feng-Yuan; Lin, Ho-Jane; Cheng, Tsun‐Jen; Chao, How‐Ran; Tai, Lin-Ai

doi:10.1016/j.jhazmat.2010.07.010

Cited by 63 publications

(34 citation statements)

References 35 publications

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“…These results are consistent with the studies that showed ZnO particle-induced increase in ICAM-1 expression in endothelial cells [36,37]. ICAM-1 can mediate the assembly of monocytes, macrophages, T lymphocytes, and platelets and their adhesion to the vascular wall, which plays a key role in the pathogenesis of atherosclerosis [38].…”

Section: In Vitro Cardiovascular Toxicity Studies Of Nanomaterialssupporting

confidence: 92%

Effects of Nanomaterials on Cardiovascular System

Ichihara

Tada‐Oikawa

Suzuki

et al. 2014

Trans. Mat. Res. Soc. Japan

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The recent explosion in the field of nanotechnology provides promising application of manufactured nanomaterials in a variety of areas. On the other hand, it has been demonstrated that the relative surface area of ultrafine carbon black or metal oxide nanoparticles correlates with the degree of their toxicity. However, due to the lack of standardized methods to determine the physicochemical behavior of nanomaterials in biological systems, the mechanisms and nature of acute or chronic toxicity of engineered nanomaterials are not fully understood. Some nanomaterials are known to generate reactive oxidant species, resulting in induction of oxidative stress and inflammation. Oxidative stress is involved in the pathogenesis of cardiovascular diseases, such as hypertension and atherosclerosis. Therefore, there is concern that nanomaterials could have a major impact on the cardiovascular system, although the effects of exposure to newly developed nanomaterials on the cardiovascular system remain elusive. This review raises issues to consider for the assessment of cardiovascular toxicity of nanomaterials, and discusses recent in vitro or in vivo toxicity studies of nanomaterials.

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Section: In Vitro Cardiovascular Toxicity Studies Of Nanomaterialssupporting

confidence: 92%

Effects of Nanomaterials on Cardiovascular System

Ichihara

Tada‐Oikawa

Suzuki

et al. 2014

Trans. Mat. Res. Soc. Japan

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“…Zinc oxide particles induce inflammatory responses in vascular endothelial cells via NF-kappaB signaling has been shown earlier [61]. Also, zinc oxide elevated circulating levels of different cytokines at low concentrations of [62].…”

Section: Discussionmentioning

confidence: 91%

Exposure to Zinc Oxide Nanoparticles Induces Neurotoxicity and Proinflammatory Response: Amelioration by Hesperidin

Ansar

Abudawood

Hamed

et al. 2016

Biol Trace Elem Res

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Zinc oxide nanoparticles (ZnONPs) are widely used in food packaging and may enter the body directly if exposed. Hereby, in this study, the oral administration was selected as the route of exposure for rats to nanoparticles and the effect of hesperidin (HSP, 100 mg/kg bwt) was evaluated on ZnONP (600 mg/kg bwt)-induced neurotoxicity in rats. ZnONPs were characterized using transmission electron microscopy. Neurotoxicity was observed as seen by elevation in serum inflammatory markers including tumor necrosis factor alpha (TNF-α), interleukin 1 (IL-1β), interleukin-6 (IL-6), C-reactive protein (CRP), and activities of catalase (CAT), glutathione peroxidase (GPx), glutathione reductase (GR), and glutathione (GSH) content in rat brains. Pretreatment of rats with HSP in ZnONP-treated group elevated activities of antioxidant enzymes. HSP also caused decrease in TNF-α, IL-1β, IL-6, and CRP levels which was higher in the ZnONP-treated group. The results suggest that HSP augments antioxidant defense with anti-inflammatory response against ZnONP-induced neurotoxicity. The increased antioxidant enzymes enhance the antioxidant potential to reduce oxidative stress.

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“…A recent study reported that ZnO NPs-induced TNF-α expression in keratinocytes is mediated via the ROS-ERK-Egr-1 pathway [3]. Another study not only demonstrated enhanced expression of ICAM-1, an inflammatory marker in 50-nm ZnO NPs-treated human endothelial (HUVEC) cells, but also demonstrated that in the presence of an inflammatory cytokine, like TNF-α; ZnO NPs-induced inflammation can be further intensified [41].…”

Section: Zno Np-mediated Immunomodulatory Responsesmentioning

confidence: 97%

Biological Reactivity of Zinc Oxide Nanoparticles With Mammalian Test Systems: an Overview

Saptarshi

Duschl

Lopata

2015

Nanomedicine (Lond.)

104

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Zinc oxide nanoparticles (ZnO NPs) have useful physicochemical advantages, and are used extensively. This has raised concerns regarding their potential toxicity. ZnO NP attributes that contribute to cytotoxicity and immune reactivity, however, seem to vary across literature considerably. Largely, dissolution and generation of reactive oxygen species appear to be the most commonly reported paradigms. Moreover, ZnO NP size and shape may also contribute toward their overall nano-bio interactions. Analysis is further complicated by factors such as adsorption of proteins on the NP surface, which may influence their bioreactivity. The main aim of this review is to give a systematic overview of the postulates explaining cytotoxic, inflammatory and genotoxic effects of ZnO NPs when exposed to different types of cells in vitro and in vivo.

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Zinc oxide particles induce inflammatory responses in vascular endothelial cells via NF-κB signaling

Cited by 63 publications

References 35 publications

Effects of Nanomaterials on Cardiovascular System

Effects of Nanomaterials on Cardiovascular System

Exposure to Zinc Oxide Nanoparticles Induces Neurotoxicity and Proinflammatory Response: Amelioration by Hesperidin

Biological Reactivity of Zinc Oxide Nanoparticles With Mammalian Test Systems: an Overview

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