Zinc Status among Type (2) Diabetes Mellitus in the State of Qatar

Daradkeh, Ghazi; Zerie, Mahmoud; Othman, Mohamad; Chandra, Prem; Jaiosi, Amin; Mahmood, Lubna; Alowainati, Buthaina; Mohammad, Ibrahim; Daghash, M. W.H.

doi:10.5963/phf0301002

Cited by 10 publications

(14 citation statements)

References 33 publications

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“…Our findings are in line with Obeid et al [56] who also demonstrated a risk of Zn deficiency in Lebanese subjects with metabolic syndrome. The low plasma Zn concentrations were also seen in obese individuals, those with hypertension and type 2 diabetes [57,58]. Fe and Cu status data were within the estimated reference ranges for adult population, and similar to the values reported elsewhere [33,59].…”

Section: Discussionsupporting

confidence: 87%

Is There a Link between Zinc Intake and Status with Plasma Fatty Acid Profile and Desaturase Activities in Dyslipidemic Subjects?

et al. 2019

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The prevalence of obesity and dyslipidemia has increased worldwide. The role of trace elements in the pathogenesis of these conditions is not well understood. This study examines the relationship between dietary zinc (Zn) intake and plasma concentrations of Zn, copper (Cu) and iron (Fe) with lipid profile indicators, fatty acid composition in plasma phospholipids and desaturase enzyme activities in a dyslipidemic population. The role of the newly proposed biomarker of Zn status, the linoleic:dihomo-gama-linolenic acid (LA:DGLA) ratio, in predicting Zn status of dyslipidemic subjects has been explored. The study included 27 dyslipidemic adults, 39-72 years old. Trace elements were determined using atomic absorption spectrometry and fatty acid composition by a liquid gas chromatography. Desaturase activities were calculated from product-precursor fatty acid ratios. Dietary data were obtained using 24 h recall questionnaires. Insufficient dietary intake of Zn, low plasma Zn concentrations and an altered Cu:Zn ratio is related to modified fatty acid profile in subjects with dyslipidemia. Plasma Zn status was associated with obesity. There was no correlation between dietary Zn intake and plasma Zn status. The LA:DGLA ratio was inversely linked to dietary Zn intake. Cu, in addition to Zn, may directly or indirectly, affect the activity of desaturase enzymes. region of Europe (54% for both sexes). Successful treatment of dyslipidemia significantly reduces morbidity and mortality from cardiovascular diseases [7]. Basically 10% reduction in serum lipid levels has been reported to result in a 50% reduction in heart disease within 5 years [1].Trace elements have crucial roles in metabolism, growth, immunological and neurological functions [8][9][10]. Zinc (Zn) is required for an adequate activity of more than 300 enzymes involved in protein synthesis, fatty acid metabolism, reproduction and oxidative clearance [11]. Iron (Fe) is needed for proper oxygen transport, while copper (Cu) is important for the oxido-reduction and detoxification and is involved in growth, development of cellular elements of arterial walls, lipoprotein metabolism and immune function [9,12,13]. The concentrations of serum/plasma minerals Zn, Cu and Fe are associated with the development of chronic diseases [10,14,15]. Deficiency in microelements leads to an increase in fat deposition and obesity [16]. Hypoferremia is often seen in people suffering from hypertension and plasma Zn concentrations have been directly correlated with total cholesterol and LDL-C levels [15,17]. Zn, Cu and Fe plasma levels are related to the extent of myocardial damage [18]. Epidemiological studies show a direct correlation between low plasma Zn and Fe concentrations and increased risk of cardiovascular diseases [19]. Elevated plasma levels of Cu were reported in patients with coronary artery disease [20]. Although deficiencies of trace elements may alter metabolism of lipids and lipoproteins, the mechanism of their action is not yet completely understood. The fatty acid (FA)...

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Section: Discussionsupporting

confidence: 87%

Is There a Link between Zinc Intake and Status with Plasma Fatty Acid Profile and Desaturase Activities in Dyslipidemic Subjects?

et al. 2019

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“…Studies of zinc concentration in the human body are scarce, and have shown inconsistent results. Zinc deficiency has been observed in patients in some counties with increased oxidative stress and generation of inflammatory status and the decrease concentrations of this element occur in patients with MS [ 3 ], in patients with type 2 diabetes mellitus [ 6 ] and with hypertension [ 7 ] than in healthy people.…”

Section: Introductionmentioning

confidence: 99%

Zinc status is associated with inflammation, oxidative stress, lipid, and glucose metabolism

et al. 2017

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A number of studies have reported that zinc plays a substantial role in the development of metabolic syndrome, taking part in the regulation of cytokine expression, suppressing inflammation, and is also required to activate antioxidant enzymes that scavenge reactive oxygen species, reducing oxidative stress. Zinc also plays a role in the correct functioning of lipid and glucose metabolism, regulating and forming the expression of insulin. In numerous studies, zinc supplementation has been found to improve blood pressure, glucose, and LDL cholesterol serum level. Deeper knowledge of zinc’s properties may help in treating metabolic syndrome, thus protecting against stroke and angina pectoris, and ultimately against death.

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“…There is not great number of public studies nowadays which examine Zn status in a human organism and present studies show the results that are not congruent (Olechnowicz, 2018). However, the majority of studies show that the Zn deficiency can be seen in states of higher oxidation stress, inflammatory process, in patients with metabolic syndrome, diabetes mellitus type 2 (DM2) and arterial hypertension (HTA) comparing to healthy population (Seo et al, 2014;Daradkeh et al 2014;Marcinek et al, 2015).…”

Section: Introductionmentioning

confidence: 73%

Zinc status in adults in northern Serbia

Todorović¹,

Čabarkapa²,

Đerić³

et al. 2019

Food & Feed Res

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Zinc plays an essential role in many enzymatic systems, cell division processes, DNAprotein synthesis, in immune system functioning, in metabolism regulation of carbohydrates, lipids and proteins: it also has anti-inflammatory and antioxidant effects. There are very few studies which have explored zinc status in general population, so the objective of this study was to examine the zinc status in general adult population in northern Serbia (Province of Vojvodina). 5025 examinees older than 18 years of age have been included in this research (4214 males and 811 females). Anthropometric measurements have been taken from all examinees (body weight and height, body mass index, waist circumference), systolic and diastolic blood pressure; laboratory parameters have been taken by the standard laboratory methods (complete blood count test, total cholesterol, triglycerides, HDLcholesterol, glucose, creatinine) while the serum concentration od Zn has been measured by the atomic absorption spectrometry. The results of our study indicate that the presence of low serum zinc concentrations was in 2.28% of males and 3.82% of females. The majority of examinees, both males and females, have had the serum zinc concentrations within the reference range (males: 95.02%, females: 94.7%). High serum zinc concentration has been present in 2.7% of examined males and in 1.48% females. It has been determined, by the analysis of examined parameters, that there is statistically positive correlation between zinc level and the red blood cell count and the hemoglobin level. However, the result of regression analysis showed that low serum zinc concentration had no role in anemia prediction. The results of the study showed that the zinc status in Vojvodina in the majority of males and females is satisfactory, regarding the fact that the low serum zinc concentrations prevalence in male population is 2.28% and in female population 3.82%.

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Zinc Status among Type (2) Diabetes Mellitus in the State of Qatar

Abstract: The results showed that zinc deficiency is common among type 2 diabetic patients due to hyperglycemia and polyurea. Periodic serum zinc measurement is recommended for type 2 diabetes mellitus.

Cited by 10 publications

References 33 publications

Is There a Link between Zinc Intake and Status with Plasma Fatty Acid Profile and Desaturase Activities in Dyslipidemic Subjects?

Is There a Link between Zinc Intake and Status with Plasma Fatty Acid Profile and Desaturase Activities in Dyslipidemic Subjects?

Zinc status is associated with inflammation, oxidative stress, lipid, and glucose metabolism

Zinc status in adults in northern Serbia

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