Zingiber mioga Extract Improves Moisturization and Depigmentation of Skin and Reduces Wrinkle Formation in UVB-Irradiated HRM-2 Hairless Mice

Abstract

Here, we investigated the effects of Zingiber mioga extracts (FSH-ZM) on the moisturization and depigmentation of skin as well as wrinkle formation in UVB-irradiated HRM-2 hairless mice. The mice were divided into six groups as follows: normal control (NC), UVB-irradiated control (C), positive control 1 (PC1, L-ascorbic acid 200 mg/kg b.w.), positive control 2 (PC2, Arbutin 200 mg/kg b.w.), Z100 (FSH-ZM 100 mg/kg b.w.), and Z200 (FSH-ZM 200 mg/kg b.w.). The experiment spanned a period of 6 weeks. We found that FSH-ZM led to an increase in the expression of hyaluronan synthase 2, fibrillin-1, and elastin mRNAs, and showed improved skin hydration in HRM-2 hairless mice compared to that in the UVB-irradiated control group. Furthermore, FSH-ZM also inhibited the expression of inflammatory cytokines and wrinkle forming factors generated by UVB and reduced the formation of wrinkles in the test group relative to that in the control group by increasing collagen synthesis. Moreover, we found that FSH-ZM decreased the expression of melanogenesis factors, which improved depigmentation in UVB-irradiated hairless mice. These results suggest that Zingiber mioga can potentially be utilized to develop products aimed at improving skin moisturization and depigmentation and reducing wrinkle formation.

Collagen Hydrolysate from the Scales of Mozambique Tilapia (Oreochromis mossambicus) Improve Hair and Skin Health by Alleviating Oxidative Stress and Inflammation and Promoting Hair Growth and Extracellular Matrix Factors

“…Enhancing the activity of these antioxidant enzymes including CAT, can delay skin and hair aging, prevent hair loss by modulating hair growth factors such as IGF-1 and VEGF, and mitigate oxidative stress-induced damage to the extracellular matrix through inhibition of oxidative stress, anti-inflammatory effects by reducing the expression of inflammatory cytokines (IL-6, IL-1β, TNF-α), and preservation of ECM integrity by increasing hyaluronic acid levels through up-regulation of HAS [ 2 , 61 , 62 , 63 ]. The hair shaft consists of three layers: the cuticle, cortex, and medulla [ 64 ].…”

Assessing Skin Healing and Angiogenesis of Deep Burns in Vivo Using Two-Photon Microscopy in Mice

“…The collagen, accounting for 70-80% of dry skin weight, is the main component of the extracellular matrix [29,30] and can be employed as an indicator in the process of dermal repair. Collagen imaging has been widely used in the transdermal movement of drugs in vivo [31], scar prognosis [32,33], and cancerous tissues [34,35].…”

Plants as Modulators of Melanogenesis: Role of Extracts, Pure Compounds and Patented Compositions in Therapy of Pigmentation Disorders

“…The main constituent was identified as ent-11-hydroxy-15-oxo-kaur-16-en-19-oic acid [ 115 ]. Improved depigmentation was observed after UVB-irradiated HRM-2 hairless mice treatment with Panax ginseng extract at doses of 150 and 300 mg/kg for 5 weeks [ 116 ] as well as 100 and 200 mg/kg of Zingiber mioga extract for 6 weeks [ 117 ]. Moreover, C57BL/6 mice and brown guinea pigs undergoing hydroquinone and H 2 O 2 induced hypopigmentation, respectively.…”