Zirconia with laser‐modified microgrooved surface vs. titanium implants covered with melatonin stimulates bone formation. Experimental study in tibia rabbits

Calvo-Guirado, José Luís; Salvatierra, Antonio Aguilar; Gargallo‐Albiol, Jordi; Delgado-Ruíz, Rafael Arcesio; Sanchez, Jose Eduardo Mate; Satorres-Nieto, Marta

doi:10.1111/clr.12472

Cited by 36 publications

(36 citation statements)

References 34 publications

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“…The results revealed that melatonin treatment significantly inhibits regional resorption of alveolar bone and contributes to periodontal healing in this experimental periodontitis rat model . Moreover, several published reports indicate that melatonin stimulates bone formation …”

Section: Prospects and Conclusionmentioning

confidence: 62%

Melatonin: Another avenue for treating osteoporosis?

Tian

Jiang

et al. 2019

Journal of Pineal Research

111

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Melatonin is a signal molecule that modulates the biological circadian rhythms of vertebrates. Melatonin deficiency is thought to be associated with several disorders, including insomnia, cancer, and cardiovascular and neurodegenerative diseases. Accumulating evidence has also indicated that melatonin may be involved in the homeostasis of bone metabolism. Age‐related reductions in melatonin are considered to be critical factors in bone loss and osteoporosis with aging. Thus, serum melatonin levels might serve as a biomarker for the early detection and prevention of osteoporosis. Compared to conventional antiosteoporosis medicines, which primarily inhibit bone loss, melatonin both suppresses bone loss and promotes new bone formation. Mechanistically, by activating melatonin receptor 2 (MT2), melatonin upregulates the gene expression of alkaline phosphatase (ALP), bone morphogenetic protein 2 (BMP2), BMP6, osteocalcin, and osteoprotegerin to promote osteogenesis while inhibiting the receptor activator of NF‐kB ligand (RANKL) pathway to suppress osteolysis. In view of the distinct actions of melatonin on bone metabolism, we hypothesize that melatonin may be a novel remedy for the prevention and clinical treatment of osteoporosis.

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Section: Prospects and Conclusionmentioning

confidence: 62%

Melatonin: Another avenue for treating osteoporosis?

Tian

Jiang

et al. 2019

Journal of Pineal Research

111

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“…The use of melatonin to promote bone regeneration in dental implant placement was assessed in several studies, based on different animal models in which the authors employed melatonin alone or in combination with other substances, such as, growth hormone or porcine bone [2,40,41,42,43,44,45,46,47]. The studies using melatonin to promote dental implant stability evaluated in this review are summarised in Table 1.…”

Section: Resultsmentioning

confidence: 99%

“…These findings agree with those obtained in implants placed in rabbit tibia, where the presence of well-remodelled cortical bone and new fronts of osteoblasts could be observed in animals treated with melatonin compared to the control group [44,46], as well as increased trabecular, but not cortical BIC. The effect of melatonin in zirconia implants was studied by the group of Calvo-Guirado [47], obtaining better results at one and four weeks in the treated implants.…”

Section: Resultsmentioning

confidence: 99%

“…The use of melatonin in implants enhances an earlier osseointegration in different animal models [2,40,41,42,43,44,45,46,47]. Melatonin produces higher values of BIC and inter-thread bone, which is based on the direct action of this molecule on the osteoblasts, with a higher rate of maturation and of bone matrix production and mineralisation [45].…”

Section: Discussionmentioning

confidence: 99%

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Melatonin: A Review of Its Potential Functions and Effects on Dental Diseases

Permuy

López-Peña

González‐Cantalapiedra

et al. 2017

IJMS

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Melatonin is a hormone synthesised and secreted by the pineal gland and other organs. Its secretion, controlled by an endogenous circadian cycle, has been proven to exert immunological, anti-oxidant, and anti-inflammatory effects that can be beneficial in the treatment of certain dental diseases. This article is aimed at carrying out a review of the literature published about the use of melatonin in the dental field and summarising its potential effects. In this review article, an extensive search in different databases of scientific journals was performed with the objective of summarising all of the information published on melatonin use in dental diseases, focussing on periodontal diseases and dental implantology. Melatonin released in a natural way into the saliva, or added as an external treatment, may have important implications for dental disorders, such as periodontal disease, as well as in the osseointegration of dental implants, due to its anti-inflammatory and osseoconductive effects. Melatonin has demonstrated to have beneficial effects on dental pathologies, although further research is needed to understand the exact mechanisms of this molecule.

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“…The effect of submerging titanium and zirconia implants in a 5% melatonin solution on the BIC after an insertion period of 1 and 4 wk was also investigated . Both titanium and zirconia implants showed a significantly higher BIC at the early (1 wk) time point (titanium, 29.7 ± 2.4 %; zirconia, 28.9 ± 1.3 %; p < 0.05).…”

Section: Resultsmentioning

confidence: 99%

Melatonin as a pro‐osteogenic agent in oral implantology: a systematic review of histomorphometric outcomes in animals and quality evaluation using ARRIVE guidelines

Arora

Ivanovski

2016

J of Periodontal Research

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The aim of this review was to evaluate the outcomes of preclinical trials that assessed the use of melatonin as a pro-osteogenic agent in the field of oral implantology. Melatonin is a hormone that has been shown to have beneficial antioxidant and bone-metabolic effects. A number of experimental studies have analysed its effect in promoting osseointegration around dental implants in animals. A bibliographic search in PubMed, Scopus and EBSCOhost was performed. Animal studies that quantitatively analysed the pro-osteogenic effect of melatonin were included. Quality assessment of the included studies was performed using the ARRIVE guidelines. Eight studies met the inclusion criteria. The experimental animals used were dogs, rabbits and rats. Melatonin was used in a lyophilized powdered form, an injectable form or as a dipping solution. Six of the eight studies included showed a statistically significant positive effect of melatonin on bone-implant contact and various other histomorphometric parameters. The ARRIVE criteria were generally well reported by the included studies (17.5 ± 1.60/24), although several criteria (including randomization and blinding) were poorly documented, with most of the studies showing a high/unclear risk of bias. The majority of the studies included showed a statistically significant positive effect of melatonin on bone formation around implants. However, the clinical significance of this effect was unclear given the high/unclear risk of bias in the majority of included studies. Given the limited amount of data available, further research should be conducted to evaluate the clinical potential of this pineal hormone in clinically relevant situations, such as compromised sites or patients.

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Zirconia with laser‐modified microgrooved surface vs. titanium implants covered with melatonin stimulates bone formation. Experimental study in tibia rabbits

Abstract: Within the limitations of this pilot study in rabbits, we can conclude that the local application of melatonin increases the BIC values in titanium and in zirconia implants at 1 week.

Cited by 36 publications

References 34 publications

Melatonin: Another avenue for treating osteoporosis?

Melatonin: Another avenue for treating osteoporosis?

Melatonin: A Review of Its Potential Functions and Effects on Dental Diseases

Melatonin as a pro‐osteogenic agent in oral implantology: a systematic review of histomorphometric outcomes in animals and quality evaluation using ARRIVE guidelines

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