Zn/Al Layered double hydroxides nanostructure as effective controlled release vehicle of nicotinic acid for topical applications

pH-Responsive Inorganic/Organic Nanohybrids System for Controlled Nicotinic Acid Drug Release

“…A previous study by Kleyi et al (2021) [ 85 ] reported the Zn/Al LDH nanostructure as an efficient topical delivery vehicle for NA. However, careful XRD observation suggested that the phase involved no single crystals, unlike ours.…”

LDH conversion films for active protection of AZ31 Mg alloy

“…Table 3 shows the basal plane spacing d calculated using Bragg's equation and the unit cell parameters a and with hydrotalcite −like systems intercalated with NO 3 − anions [47] . The shoulder peaks identified for (003) and (006) reflexions at slightly higher 2 −theta values suggest the partial intercalation of CO 3 2 − /OH − ions between the LDH layers [48] . The d 003 values correspond to the basal spacing of two consecutive hydrotalcite −like layers, therefore, it is possible to calculate the intergallery height by subtracting the basal spacing of the cationic layer (brucite −like, 4.8 Å) ( Table 3 ).…”

“…The inhibitor Li + in the Li −Al LDH-Li system is not likely to be incorporated between the LDH layers due to its positive charge. Li + is most probably − ions intercalated between the LDH layers, respectively [48] . The band at 1690 −1480 cm −1 could also be correlated to the symmetric stretching vibra- XPS analysis ( Fig.…”

Biomaterials Based on Organic Polymers and Layered Double Hydroxides Nanocomposites: Drug Delivery and Tissue Engineering

“…For example, LDHs can intercalate bioactive species establishing arrangements and physical interactions that favor solubilization compared to those ones in the pristine drug crystal. Many drugs, such as the anti-inflammatories ibuprofen [ 202 ] and zaltoprofen [ 203 ], the diuretic piretanide [ 204 ], and the vitamin B3 (nicotinic acid) [ 205 ], among others, were manipulated by intercalation into LDH to overcome the low solubility challenge. The solubility test of zaltoprofen in water and phosphate buffer (pH equal to 6.8) showed that its intercalation into Zn R Al-LDH improved three times its solubility compared to the non-intercalated drug [ 203 ] and presented better performance than the physical mixture of zaltoprofen and LDH, demonstrating the benefits of the DDS approach.…”

“…The oxidation rate of the confined vitamin was slower when compared to the free vitamin. Vitamin B3 (nicotinic acid), which is also very sensitive to degradation processes, was protected and presented better thermal stability intercalated into the Zn R Al-LDH when compared to the free molecule [ 205 ].…”