ZnO nanoflower based electrochemical sensor for the selective determination of venlafaxine

Zaimbashi, Reza; Mostafavi, Ali; Shamspur, Tayebeh

doi:10.1007/s13738-021-02383-w

Cited by 1 publication

(1 citation statement)

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“…The modified electrodes with metal NPs such as Pd-Ni/C [41], Au/C [42][43][44][45], Ni/graphite [46,47], and Pt-Co/CNT [48] are widely used for various electrochemical applications. In recent years, most studies have focused on VEN electrochemical sensing using various metal oxides [49][50][51][52], whereas metal NP-based electrochemical sensors for VEN studies are rather scarce. Hence, in the current article, we report the synthesis of Co-Pd@Al 2 O 3 bimetallic catalysts and their deposition on GCE for designing a voltammetric sensor to detect venlafaxine in human serum samples.…”

Section: Introductionmentioning

confidence: 99%

A Novel Electrochemical Sensing Platform for the Detection of the Antidepressant Drug, Venlafaxine, in Water and Biological Specimens

et al. 2022

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A stable bimetallic catalyst composed of Co–Pd@Al2O3 was synthesized using a wet impregnation method, followed by calcination and H2 reduction. The synthesized catalyst was thoroughly characterized using XRD, BET, SEM, EDX, and TPR techniques. The catalyst was then drop-casted on a glassy carbon electrode (Co–Pd@Al2O3/GCE) and applied for the sensitive and selective electrochemical determination of a common antidepressant drug, venlafaxine (VEN). The proposed sensor (Co–Pd@Al2O3/GCE) demonstrated a remarkable catalytic activity for the electro-oxidation of VEN, with a decent repeatability and reproducibility. The pH dependent responsiveness of the electro-oxidation of VEN helped in proposing the redox mechanism. A linear relationship between the peak current and concentration of VEN was observed in the range of 1.95 nM to 0.5 µM, with LOD and LOQ of 1.86 pM and 6.20 pM, respectively. The designed sensor demonstrated an adequate selectivity and significant stability. Moreover, the sensor was found to be quite promising for determining the VEN in biological specimens.

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