ZnO nanoparticles induced inflammatory response and genotoxicity in human blood cells: A mechanistic approach

Senapati, Violet Aileen; Kumar, Ashutosh; Gupta, Govind; Pandey, Alok Kumar; Dhawan, Alok

doi:10.1016/j.fct.2015.06.018

Cited by 90 publications

(58 citation statements)

References 47 publications

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“…(For interpretation of the references to color in this figure legend, the reader is referred to the web version of this article.) documented in vitro [7][8][9][10][11]28,80], but also in vivo [12,13], although other studies do not reach the same conclusion (e.g. [14]), and our results may shed new light in this area.…”

Section: Discussionmentioning

confidence: 36%

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A combined proteomic and targeted analysis unravels new toxic mechanisms for zinc oxide nanoparticles in macrophages

Aude-Garcia

Dalzon

Ravanat

et al. 2016

Journal of Proteomics

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The responses of the murine J774 macrophage cell lines to two types of metallic oxide nanoparticles (zinc oxide and zirconium dioxide) were studied by a comparative 2D gel based approach. This allows sorting of shared responses from nanoparticle-specific responses. Zinc oxide nanoparticles induced specifically a strong decrease in the mitochondrial function, in phagocytosis and also an increase in the methylglyoxal-associated DNA damage, which may explain the well known genotoxicity of zinc. In conclusion, this study allows highlighting of pathways that may play an important role in the toxicity of the zinc oxide nanoparticles.

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Section: Discussionmentioning

confidence: 36%

“…There has been quite active research to determine the toxic mechanisms of these nanoparticles, and many papers imply the oxidative stress pathway, [6,7], leading to DNA damage and genotoxicity in vitro [8][9][10][11] but also in vivo [12,13], although this is still a controversial issue [14].…”

Section: Introductionmentioning

confidence: 99%

A combined proteomic and targeted analysis unravels new toxic mechanisms for zinc oxide nanoparticles in macrophages

Aude-Garcia

Dalzon

Ravanat

et al. 2016

Journal of Proteomics

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“…Those effects significantly increased when the keratinocytes were exposed to the UV radiation. Similar cyto- and genotoxicity effects of ZnO NPs were observed in human monocytes (THP-1 line) [90, 91] and human lung adenocarcinoma epithelial cells (A549 line) [92], as well as in fish embryos, e.g., Danio rerio [93]. …”

Section: Reviewmentioning

confidence: 73%

Nanoparticles of Titanium and Zinc Oxides as Novel Agents in Tumor Treatment: a Review

2017

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Cancer has become a global problem. On all continents, a great number of people are diagnosed with this disease. In spite of the progress in medical care, cancer still ends fatal for a great number of the ill, either as a result of a late diagnosis or due to inefficiency of therapies. The majority of the tumors are resistant to drugs. Thus, the search for new, more effective therapy methods continues. Recently, nanotechnology has been attributed with big expectations in respect of the cancer fight. That interdisciplinary field of science creates nanomaterials (NMs) and nanoparticles (NPs) that can be applied, e.g., in nanomedicine. NMs and NPs are perceived as very promising in cancer therapy since they can perform as drug carriers, as well as photo- or sonosensitizers (compounds that generate the formation of reactive oxygen species as a result of either electromagnetic radiation excitation with an adequate wavelength or ultrasound activation, respectively). Consequently, two new treatment modalities, the photodynamic therapy (PDT) and the sonodynamic therapy (SDT) have been created. The attachment of ligands or antibodies to NMs or to NPs improve their selective distribution into the targeted organ or cell; hence, the therapy effectiveness can be improved. An important advantage of the targeted tumor treatment is lowering the cyto- and genotoxicity of active substance towards healthy cells. Therefore, both PDT and SDT constitute a valuable alternative to chemo- or radiotherapy. The vital role in cancer eradication is attributed to two inorganic sensitizers in their nanosized scale: titanium dioxide and zinc oxide.

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“…The induction of oxidative and nitrosative stress by zinc oxide nanoparticles was described as a mechanism through which these particles activate redox-sensitive NF-κB and MAPK signaling pathways, leading to an inflammatory response in human monocytes (Senapati et al, 2015). The oxidative stress induced by the nanoemulsion Cremophor-EL was also suggested to trigger IL-8 production by human monocytes via a mechanism that bypasses gene expression (Ilinskaya et al, 2015).…”

Section: Disappointmentsmentioning

confidence: 99%

Current understanding of interactions between nanoparticles and the immune system

Dobrovolskaia

Shurin

Shvedova

2016

Toxicology and Applied Pharmacology

261

189

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The delivery of drugs, antigens, and imaging agents benefits from using nanotechnology-based carriers. The successful translation of nanoformulations to the clinic involves thorough assessment of their safety profiles, which, among other endpoints, includes evaluation of immunotoxicity. The past decade of research focusing on nanoparticle interaction with the immune system has been fruitful in terms of understanding the basics of nanoparticle immunocompatibility, developing a bioanalytical infrastructure to screen for nanoparticle-mediated immune reactions, beginning to uncover the mechanisms of nanoparticle immunotoxicity, and utilizing current knowledge about the structure–activity relationship between nanoparticles’ physicochemical properties and their effects on the immune system to guide safe drug delivery. In the present review, we focus on the most prominent pieces of the nanoparticle–immune system puzzle and discuss the achievements, disappointments, and lessons learned over the past 15 years of research on the immunotoxicity of engineered nanomaterials.

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ZnO nanoparticles induced inflammatory response and genotoxicity in human blood cells: A mechanistic approach

Cited by 90 publications

References 47 publications

A combined proteomic and targeted analysis unravels new toxic mechanisms for zinc oxide nanoparticles in macrophages

A combined proteomic and targeted analysis unravels new toxic mechanisms for zinc oxide nanoparticles in macrophages

Nanoparticles of Titanium and Zinc Oxides as Novel Agents in Tumor Treatment: a Review

Current understanding of interactions between nanoparticles and the immune system

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