2011
DOI: 10.1016/j.ejca.2010.11.024
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Zoledronic acid preserves bone mineral density in premenopausal women who develop ovarian failure due to adjuvant chemotherapy: Final results from CALGB trial 79809

Abstract: Background Chemotherapy-induced ovarian failure (CIOF) is a frequent side effect of adjuvant chemotherapy that results in rapid bone loss. We hypothesized that zoledronic acid (ZA), a third-generation amino bisphosphonate, would prevent bone loss in premenopausal women who developed CIOF. Methods 439 women were randomized to intravenous (IV) ZA 4 mg every 3 months for 2 years starting within 1–3 months (mos) after randomization (arm A) or 1 year after randomization (arm B, controls). CIOF was prospectively d… Show more

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Cited by 89 publications
(70 citation statements)
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“…Few trials have evaluated the efficacy of bisphosphonates to attenuate chemotherapy-induced bone loss in young women [156][157][158][159][160][161][162][163][164]. The administration of oral clodronate at daily doses of 1,600 mg, oral risedronate at a dose of 30 mg/day, cyclical intravenous pamidronate at doses of 60 mg every 3 months and intravenous zoledronic acid at a dose of 4 mg every 3 months prevented chemotherapy-induced bone loss in these studies.…”
Section: Breast Cancermentioning
confidence: 99%
“…Few trials have evaluated the efficacy of bisphosphonates to attenuate chemotherapy-induced bone loss in young women [156][157][158][159][160][161][162][163][164]. The administration of oral clodronate at daily doses of 1,600 mg, oral risedronate at a dose of 30 mg/day, cyclical intravenous pamidronate at doses of 60 mg every 3 months and intravenous zoledronic acid at a dose of 4 mg every 3 months prevented chemotherapy-induced bone loss in these studies.…”
Section: Breast Cancermentioning
confidence: 99%
“…Tamoxifen and other SERMs are an exception and exert a bone-protective effect in postmenopausal, but not premenopausal, women with BC [23][24][25]. Indeed, SERMS inhibit estradiol signaling, causing subsequent decrease in BMD in premenopausal women [16,18]. Ovarian ablation in premenopausal women causes immediate, artificial menopause.…”
Section: Bone Effects Of Breast Cancer Treatmentmentioning
confidence: 99%
“…Adjuvant hormonal therapies (e.g, ovarian suppression, AIs) dramatically decrease estrogen levels in pre-and postmenopausal women, resulting in increased osteoclast-mediated bone resorption and subsequent BMD decrease [16,18,23]. Tamoxifen and other SERMs are an exception and exert a bone-protective effect in postmenopausal, but not premenopausal, women with BC [23][24][25].…”
Section: Bone Effects Of Breast Cancer Treatmentmentioning
confidence: 99%
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