Zonisamide for Weight Loss in Adolescents

Nguyen, Mathew; Pirzada, Mustafa H; Shapiro, Michael A.

doi:10.5863/1551-6776-18.4.311

Cited by 7 publications

(5 citation statements)

References 10 publications

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“…That being said, there are a few case reports that match our findings and indicate that zonisamide also contributes to weight reduction in children and adolescents. 41,42 Considering that our findings suggest that these anticonvulsants are effective for weight reduction even when patients are gaining a significant amount of weight from antipsychotics, both anticonvulsants are promising agents for future research into how to counteract weight gain associated with antipsychotics commonly observed in psychiatric clinics.…”

Section: Discussionmentioning

confidence: 88%

Topiramate, zonisamide and weight loss in children and adolescents prescribed psychiatric medications

Shapiro

Reid

Olsen

et al. 2015

Int J Psychiatry Med

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Section: Discussionmentioning

confidence: 88%

Topiramate, zonisamide and weight loss in children and adolescents prescribed psychiatric medications

Shapiro

Reid

Olsen

et al. 2015

Int J Psychiatry Med

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“…Zonisamide is an antiepileptic medication approved by the FDA as an adjunct therapy in partial seizures for adolescents of 16 years and adults [ 100 ]. The addition of zonisamide to treating a 15-year-old obese male admitted to the hospital for depression and anxiety symptoms resulted in appetite suppression by acting on the hypothalamus, weight loss and normalization of his triglyceride levels [ 101 ]. In addition, results from clinical trials investigating the effect of zonisamide as add-on therapy in children suffering from partial seizures on weight reduction showed that about 35.8% of the treated patients experienced significant weight reduction (≥5% reduction of body weight) [ 102 ].…”

Section: Treatmentmentioning

confidence: 99%

Risk Factors, Clinical Consequences, Prevention, and Treatment of Childhood Obesity

et al. 2022

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Obesity might adversely affect the health and well-being of children and their families. Childhood obesity has crucial implications for health, both during childhood and as they age. It is highly associated with many acute problems and is commonly present during childhood, making visits and hospital admissions polarized in this group of children. The problems that may affect these children can be medical, such as asthma, chronic inflammation, orthopedic abnormalities, liver disease, diabetes mellitus or dyslipidemia. Long-term consequences of cardiovascular risk factors, the persistence of obesity and premature mortality are common among adults who had obesity during their early lives. Additionally, they could also suffer from psychological issues, such as low self-esteem, which puts them at risk of a much more serious psychosocial problem that may lead to depression, as well as a disruption in educational achievements and social relationships. A healthy diet, physical activity, adequate sleep, and limited screen time are all preventive measures that should be implemented at the family and community levels, preferably through well-structured programs. Furthermore, pharmacological management of childhood obesity is limited and only used after non-pharmacological interventions have failed or in the late stages of obesity. However, recent guidelines advocate the early use of medical interventions. Approved pharmacotherapeutic options include orlistat, phentermine/topiramate combination and liraglutide. There are several other options approved primarily for other specific forms of obesity or for other indications, including setmelanotide, metformin, lisdexamfetamine, zonisamide and fluoxetine. Bariatric surgery is a safe and effective option in cases with extreme obesity and comorbidities considering the need for long-term monitoring and support for cases and their families post-surgery. This review aims to discuss and highlight the recent evidence regarding risk factors, clinical consequences, prevention, and treatment of childhood obesity.

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“…Adult patients have experienced weight loss with the use of zonisamide 57 . A small number of pilot data have shown that zonisamide may potentially be effective for weight loss in the paediatric population 116,135 . Further research is required to investigate the efficacy and safety of this medication for weight loss in children and young people.…”

Section: Definitionmentioning

confidence: 99%

Childhood obesity: A review of current and future management options

Apperley

Blackburn

Erlandson-Parry

et al. 2021

Clinical Endocrinology

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Obesity is becoming increasingly prevalent in paediatric populations worldwide. In addition to increasing prevalence, the severity of obesity is also continuing to rise. Taken together, these findings demonstrate a worrying trend and highlight one of the most significant challenges to public health. Childhood obesity affects multiple organs in the body and is associated with both significant morbidity and ultimately premature mortality. The prevalence of complications associated with obesity, including dyslipidaemia, hypertension, fatty liver disease and psychosocial complications are becoming increasingly prevalent within the paediatric populations. Treatment guidelines currently focus on intervention with lifestyle and behavioural modifications, with pharmacotherapy and surgery reserved for patients who are refractory to such treatment. Research into adult obesity has established pharmacological novel therapies, which have been approved and established in clinical practice; however, the research and implementation of such therapies in paediatric populations have been lagging behind. Despite the relative lack of widespread research in comparison to the adult population, newer therapies are being trialled, which should allow a greater availability of treatment options for childhood obesity in the future. This review summarizes the current evidence for the management of obesity in terms of medical and surgical options. Both future therapeutic agents and those which cause weight loss but have an alternative indication are also included and discussed as part of the review. The review summarizes the most recent research for each intervention and demonstrates the potential efficacy and limitations of each treatment option.

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Zonisamide for Weight Loss in Adolescents

Cited by 7 publications

References 10 publications

Topiramate, zonisamide and weight loss in children and adolescents prescribed psychiatric medications

Topiramate, zonisamide and weight loss in children and adolescents prescribed psychiatric medications

Risk Factors, Clinical Consequences, Prevention, and Treatment of Childhood Obesity

Childhood obesity: A review of current and future management options

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