Zoonotic coronavirus epidemics

Fung, Monica; Otani, Iris M.; Pham, Minh Tu; Babik, Jennifer M.

doi:10.1016/j.anai.2020.11.021

Cited by 10 publications

(4 citation statements)

References 242 publications

(302 reference statements)

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“…Since the discovery of Coronaviruses 90 years ago(V’kovski et al, 2021), more than 30 different coronaviruses have been discovered so far, 6 of which infect humans. During this millennium, three zoonotic outbreaks of severe acute respiratory syndrome coronaviruses have taken place: SARS-CoV in 2002-2003, Middle East respiratory syndrome coronavirus (MERS-CoV) in 2012, and the one we are currently experiencing, SARS-CoV-2, which generated the most critical pandemic experienced so far by humans(Fung et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

Towards an optimal monoclonal antibody with higher binding affinity to the receptor-binding domain of SARS-CoV-2 spike proteins from different variants

Neamţu

Mocci

Laaksonen

et al. 2022

Preprint

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A highly efficient and robust multiple scales in silico protocol, consisting of atomistic constant charge Molecular Dynamics (MD), constant-charge coarse-grain (CG) MD and constant-pH CG Monte Carlo (MC), has been used to study the binding affinities, the free energy of complexation of selected antigen-binding fragments of the monoclonal antibody (mAbs) CR3022 (originally derived from SARS-CoV-1 patients almost two decades ago) and 11 SARS-CoV-2 variants including the wild type. CR3022 binds strongly to the receptor-binding domain (RBD) of SARS-CoV-2 spike protein, but chooses a different site rather than the receptor-binding motif (RBM) of RBD, allowing its combined use with other mAbs against new emerging virus variants. Totally 235,000 mAbs structures were generated using the RosettaAntibodyDesign software, resulting in top 10 scored CR3022-RBD complexes with critical mutations and compared to the native one, all having the potential to block virus-host cell interaction. Of these 10 finalists, two candidates were further identified in the CG simulations to be clearly best against all virus variants, and surprisingly, all 10 candidates and the native CR3022 did exhibit a higher affinity for the Omicron variant with its highest number of mutations (15) of them all considered in this study. The multiscale protocol gives us a powerful rational tool to design efficient mAbs. The electrostatic interactions play a crucial role and appear to be controlling the affinity and complex building. Clearly, mAbs carrying a lower net charge show a higher affinity. Structural determinants could be identified in atomistic simulations and their roles are discussed in detail to further hint at a strategy towards designing the best RBD binder. Although the SARS-CoV-2 was specifically targeted in this work, our approach is generally suitable for many diseases and viral and bacterial pathogens, leukemia, cancer, multiple sclerosis, rheumatoid, arthritis, lupus, and more.

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Section: Introductionmentioning

confidence: 99%

Towards an optimal monoclonal antibody with higher binding affinity to the receptor-binding domain of SARS-CoV-2 spike proteins from different variants

Neamţu

Mocci

Laaksonen

et al. 2022

Preprint

View full text Add to dashboard Cite

show abstract

“…Covid-19, an abbreviation for Coronavirus Disease 2019, is a new type of disease caused by the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-COV-2) virus, previously called the Coronavirus novel (2019-NCOV). This new virus is very contagious and quickly spreads globally (Fung et al, 2021;Martínez & Short, 2021;Sabin et al, 2020;Wong et al, 2020).…”

Section: Covid-19mentioning

confidence: 99%

Integrated Environmental Assessment of COVID-19 Hazardous Waste Management Policy and Strategy in Jakarta’s Quarantine and Self-Isolation Location

Sharyne Sylvani,

Dr. Rachmadhi Purwana,

Dr. Haryoto Kusnoputranto

2023

theijhss

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The COVID-19 pandemic has changed the dynamics of global waste generation, so it needs special attention. Recently, many studies have been carried out to confirm the transmission of COVID-19 through waste. Waste management is becoming a more severe issue for countries that cannot provide adequate facilities for safety and hygiene practices, such as adequate PPE. Jakarta is one of the provinces with the most severe impact of the COVID-19 pandemic. The number of COVID-19 cases in Jakarta is the highest in Indonesia. In addition to the highest number of cases, the number of COVID-19 hazardous waste generation also occupies the highest position. At the beginning of the emergence of the COVID-19 pandemic, the Government issued several policies to regulate the management of COVID-19 hazardous waste. However, several spilt COVID-19 hazardous waste cases were found at several points in Jakarta. This study aims to examine government policies and the interrelationships of the impact of waste management amid a pandemic and describe the management of COVID-19 hazardous waste in an outline to recommend later strategies for handling the generation of COVID-19 hazardous waste. This research is analyzed using SWOT and DPSIR. It is concluded that to effectively manage COVID-19 hazardous waste, policies, infrastructure development, public awareness, education, waste reduction measures, collaboration, monitoring, enforcement, and research and innovation is critical. Raising awareness about government policies regarding COVID-19 waste management is essential to encourage responsible behavior and prevent potential risks associated with improper waste handling.

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“…Thus, the animals are a favorable intermediate host for some viruses, which makes dromedary husbandry a relevant risk factor for zoonotic disease transmission (Zhu et al 2019 ). In the last decades, some significant zoonotic diseases have been caused by corona viruses (Fung et al 2021 ) and camels are reservoirs and carriers of various coronavirus strains (Kandeel and Al-Mubarak 2022 ). During the outbreak of MERS (Middle East Respiratory Syndrome) in 2012, the dromedary was identified as the intermediate host from which the spillover of the virus to humans originated (Zhu et al 2019 ).…”

Section: Introductionmentioning

confidence: 99%

Detection of viral antibodies in camel sera using magnetic particle spectroscopy

Friedrich

Vogel

Rückert

et al. 2023

Appl Microbiol Biotechnol

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Pandemics like SARS-Cov-2 very frequently have their origin in different animals and in particular herds of camels could be a source of zoonotic diseases. This study took advantage on a highly sensitive and adaptable method for the fast and reliable detection of viral antibodies in camels using low-cost equipment. Magnetic nanoparticles (MNP) have high variability in their functionalization with different peptides and proteins. We confirm that 3-aminopropyl triethoxysilane (APTES)-coated MNP could be functionalized with viral proteins. The protein loading could be confirmed by simple loading controls using FACS-analysis (p < 0.05). Complementary combination of antigen and antibody yields in a significant signal increase could be proven by both FACS and COMPASS. However, COMPASS needs only a few seconds for the measurement. In COMPASS, the phase φn on selected critical point of the fifth higher harmonic (n = 5th). Here, positive sera display highly significant signal increase over the control or negative sera. Furthermore, a clear distinction could be made in antibody detection as an immune response to closely related viruses (SARS-CoV2 and MERS). Using modified MNPs along with COMPASS offers a fast and reliable method that is less cost intensive than current technologies and offers the possibility to be quickly adapted in case of new occurring viral infections. Key points • COMPASS (critical offset magnetic particle spectroscopy) allows the fast detection of antibodies. • Magnetic nanoparticles can be adapted by exchange of the linked bait molecule. • Antibodies could be detected in camel sera without washing steps within seconds.

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Zoonotic coronavirus epidemics

Cited by 10 publications

References 242 publications

Towards an optimal monoclonal antibody with higher binding affinity to the receptor-binding domain of SARS-CoV-2 spike proteins from different variants

Towards an optimal monoclonal antibody with higher binding affinity to the receptor-binding domain of SARS-CoV-2 spike proteins from different variants

Integrated Environmental Assessment of COVID-19 Hazardous Waste Management Policy and Strategy in Jakarta’s Quarantine and Self-Isolation Location

Detection of viral antibodies in camel sera using magnetic particle spectroscopy

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