Zum Problem des Einflusses moderner jodhaltiger Kontrastmittel auf den Stoffwechsel der Thyreoidea im S�uglingsalter

Grüters, Annette; Lallemand, D; Klett, M.; Helge, H.

doi:10.1159/000413753

Cited by 1 publication

(2 citation statements)

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“…Berlin -(specific activity 115 pCi/pg) and hTSH standard preparation MRC 68/38 (National Institute of Standards, London) in an incubation vol ume of 300 pl/tube. Our normal values for healthy neonates were: TSH < 6 p U /m l, T4 [8][9][10][11][12][13][14][15][16][17][18] pg/dl and T 3 0.9-2.5 ng/ml. According to published [11][12][13] and limited own data for healthy preterm infants beyond the 30th week of gestation, normal TSH is < 6 p U /m l. T4 ranges from 4.0 to 10.1 and T 3 from 0.68 to 1.1. ng/ml.…”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Iodine in Contrast Agents and Skin Disinfectants Is the Major Cause for Hypothyroidism in Premature Infants during Intensive Care

l’Allemand

Grüters²,

Beyer

et al. 1987

Horm Res

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In 51 sick newborns the influence of two different nonionic, iodine-containing contrast agents, Amipaque® (group 1) and Omnipaque® (group 2) and of long-term treatment with polyvinylpyrrolidone-iodine (PVP-I) (group 3) on thyroid function was studied. In the dose given, freshly dissolved Amipaque® releases roughly 100 µg ‘free’ iodide/kg body weight; this release may be even higher in the solubilized agent Omnipaque® because of increased breakdown. Urinary iodine excretion was elevated in all groups on day 5 after iodine exposure. In group 1 which included 17 term newborns, the median TSH level was normal after 5 days and 2 weeks, only 1 case of transient hypothyrotropinemia was observed; T₄ and T₃ median levels were in the lower range of normal. In groups 2 and 3, which included 8 preterm infants of 15 newborns and 9 preterm infants of 19 newborns, respectively, the median TSH values were elevated and T₄ and T₃ levels were very low. Hypothyroidism was diagnosed in 6 of the 8 preterm and in 1 of the 7 term newborns of group 2. In group 3, 7 of the 9 preterm and 3 of the 10 term newborns reacted with hypothyroidism. Eight preterm and 3 term newborns had to be substituted with thyroxine. The thyroid function of term newborns was less affected by Amipaque® or Omnipaque® than by PVP-I. The data show that preterm infants are very sensitive to an iodine load.

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Section: Methodsmentioning

confidence: 99%

“…In other studies, however, no thyroid dysfunction was found after application of iodine-containing prepa rations in neonates [7][8][9][10], These discrepan-…”

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confidence: 88%