Zur Bedeutung des interparietalen Syndroms bei der Schizophrenie

Angyal, L. v.

doi:10.1007/bf01813798

Cited by 8 publications

(2 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We selected this cortical area for several reasons. First, early neuropathological investigations noted that the IPL is among the most seriously damaged cortical regions in SZ (von Angyal, 1934). Second, imaging studies have reported decreased volume and differences in asymmetry as compared with controls (Goldstein et al, 1999;Niznikiewicz et al, 2000;Frederikse et al, 2000).…”

Section: Introductionmentioning

confidence: 99%

Growth Arrest and DNA-Damage-Inducible, Beta (GADD45b)-Mediated DNA Demethylation in Major Psychosis

Gavin

Sharma

Chase

et al. 2011

Neuropsychopharmacol

103

119

View full text Add to dashboard Cite

Aberrant neocortical DNA methylation has been suggested to be a pathophysiological contributor to psychotic disorders. Recently, a growth arrest and DNA-damage-inducible, beta (GADD45b) protein-coordinated DNA demethylation pathway, utilizing cytidine deaminases and thymidine glycosylases, has been identified in the brain. We measured expression of several members of this pathway in parietal cortical samples from the Stanley Foundation Neuropathology Consortium (SFNC) cohort. We find an increase in GADD45b mRNA and protein in patients with psychosis. In immunohistochemistry experiments using samples from the Harvard Brain Tissue Resource Center, we report an increased number of GADD45b-stained cells in prefrontal cortical layers II, III, and V in psychotic patients. Brain-derived neurotrophic factor IX (BDNF IXabcd) was selected as a readout gene to determine the effects of GADD45b expression and promoter binding. We find that there is less GADD45b binding to the BDNF IXabcd promoter in psychotic subjects. Further, there is reduced BDNF IXabcd mRNA expression, and an increase in 5-methylcytosine and 5-hydroxymethylcytosine at its promoter. On the basis of these results, we conclude that GADD45b may be increased in psychosis compensatory to its inability to access gene promoter regions.

show abstract

Section: Introductionmentioning

confidence: 99%

Growth Arrest and DNA-Damage-Inducible, Beta (GADD45b)-Mediated DNA Demethylation in Major Psychosis

Gavin

Sharma

Chase

et al. 2011

Neuropsychopharmacol

103

119

View full text Add to dashboard Cite

show abstract

“…All of these regions have been reported to exhibit structural or functional changes in schizophrenia [Farrer et al, 2004[Farrer et al, , 2008Fuller Torrey, 2007]. von Angyal as early as 1934[von Angyal, 1934 observed that the IPL (including the SMG and ANG) were among the cortical regions most seriously damaged in schizophrenia patients. A recent study has also provided evidence that misattributions of agency in schizophrenia are due to impaired predictions concerning the sensory consequences of one's own actions [Synofzik et al, 2010] in line with proposed comparator model of self discussed above [Christoff et al, 2011].…”

Section: Discussionmentioning

confidence: 99%

Key functional circuitry altered in schizophrenia involves parietal regions associated with sense of self

Guo

Kendrick

et al. 2012

Hum. Brain Mapp

View full text Add to dashboard Cite

There is still no clear consensus as to which of the many functional and structural changes in the brain in schizophrenia are of most importance, although the main focus to date has been on those in the frontal and cingulate cortices. In the present study, we have used a novel holistic approach to identify brain-wide functional connectivity changes in medicated schizophrenia patients, and functional connectivity changes were analyzed using resting-state fMRI data from 69 medicated schizophrenia patients and 62 healthy controls. As far as we are aware, this is the largest population reported in the literature for a resting-state study. Voxel-based morphometry was also used to investigate gray and white matter volume changes. Changes were correlated with illness duration/symptom severity and a support vector machine analysis assessed predictive validity. A network involving the inferior parietal lobule, superior parietal gyrus, precuneus, superior marginal, and angular gyri was by far the most affected (68% predictive validity compared with 82% using all connections) and different components correlated with illness duration and positive and negative symptom severity. Smaller changes occurred in emotional memory and sensory and motor processing networks along with weakened interhemispheric connections. Our findings identify the key functional circuitry altered in schizophrenia involving the default network midline cortical system and the cortical mirror neuron system, both playing important roles in sensory and cognitive processing and particularly self-processing, all of which are affected in this disorder. Interestingly, the functional connectivity changes with the strongest links to schizophrenia involved parietal rather than frontal regions.

show abstract

Coincidence of Interparietal Syndrome and Automatic Changes of Posture in a Case of Schizophrenia

Angyal¹

1937

Arch NeurPsych

View full text Add to dashboard Cite

Zur Bedeutung des interparietalen Syndroms bei der Schizophrenie

Cited by 8 publications

References 3 publications

Growth Arrest and DNA-Damage-Inducible, Beta (GADD45b)-Mediated DNA Demethylation in Major Psychosis

Growth Arrest and DNA-Damage-Inducible, Beta (GADD45b)-Mediated DNA Demethylation in Major Psychosis

Key functional circuitry altered in schizophrenia involves parietal regions associated with sense of self

Coincidence of Interparietal Syndrome and Automatic Changes of Posture in a Case of Schizophrenia

Contact Info

Product

Resources

About